Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2025 Volume 30 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2025 Volume 30 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness 
by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway

  • Authors:
    • Yahong Sun
    • Xingxing Zhu
    • Lina Yu
    • Hui Dong
    • Zhihao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Haining People's Hospital, Haining, Zhejiang 314400, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 487
    |
    Published online on: August 19, 2025
       https://doi.org/10.3892/ol.2025.15233
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer‑associated mesenchymal stem cells (CA‑MSCs) modulate the tumor microenvironment and promote tumor progression. The present study aimed to investigate the effects of CA‑MSCs, CA‑MSC‑derived exosomes and CA‑MSC exosome‑derived microRNA (miR)‑182 on non‑small cell lung cancer (NSCLC) cell viability and invasiveness. CA‑MSCs were established by treating MSCs with supernatant from NSCLC cells. Then, two NSCLC cell lines (A549 and H1299) were treated with CA‑MSCs, CA‑MSCs + GW4869 (inhibits exosomes) and CA‑MSC exosomes. Additionally, miR‑182 inhibitor was added to CA‑MSCs and the related exosomes were used to treat NSCLC cells. Furthermore, miR‑182 mimic and F‑box and WD repeat domain containing 7 (FBXW7) overexpression vector were used to treat NSCLC cells. The results indicated that CA‑MSCs promoted NSCLC cell viability and invasiveness and inhibited cell apoptosis, an effect that was attenuated following GW4869 treatment. The CA‑MSC exosomes also enhanced NSCLC cell viability and invasiveness while inhibiting cell apoptosis. In addition, CA‑MSC exosomes elevated miR‑182 expression in NSCLC cells. Subsequently, CA‑MSC exosomes with miR‑182 expression knockdown exhibited a weakened effect on NSCLC cell viability, apoptosis and invasiveness compared with control CA‑MSC exosomes. Direct miR‑182 mimic transfection enhanced NSCLC cell viability and invasiveness and inhibited cell apoptosis, an effect that was attenuated by transfection with the FBXW7 overexpression vector. Furthermore, miR‑182 negatively regulated and sponged FBXW7 expression in NSCLC cells. Finally, treatment of the cells with miR‑182 mimic increased the phosphorylated (p‑)AKT and p‑ERK1/2 expression levels, while treatment with the FBXW7 overexpression vector decreased these levels in NSCLC cells. In summary, CA‑MSCs facilitated NSCLC viability and invasiveness via transmitting exosomal miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway.
View Figures

Figure 1

CA-MSCs promote non-small cell lung
cancer cell viability and invasiveness via delivering exosomes.
Comparison of the (A) viability, (B) number of invasive cells
(magnification, ×200) and (C) apoptosis rate of A549 cells in the
Mock, CA-MSC, CA-MSC-GW and CA-MSC Exo groups. Comparison of the
(D) viability, (E) number of invasive cells (magnification, ×200)
and (F) apoptosis rate of H1299 cells in the Mock, CA-MSC,
CA-MSC-GW and CA-MSC Exo groups. *P<0.05, **P<0.01 and
***P<0.001; ns, no significance. CA-MSC, cancer-associated
mesenchymal stem cell; CA-MSC-GW, GW4869-treated CA-MSCs; CA-MSC
Exo, exosomes derived from CA-MSCs.

Figure 2

miR-182 expression quantifications.
miR-182 expression in (A) A549 cells and (B) H1299 cells in the
Mock, CA-MSC, CA-MSC-GW and CA-MSC Exo groups. After transfection,
miR-182 expression in CA-MSCs cocultured with (C) A549 and (D)
H1299 cells and the corresponding (E,F) CA-MSC exosomes, in the
Control, NC-inh and miR-inh Exo groups. *P<0.05, **P<0.01 and
***P<0.001; ns, no significance. miR-182, microRNA-182; CA-MSC,
cancer-associated mesenchymal stem cell; CA-MSC-GW, GW4869-treated
CA-MSCs; CA-MSC Exo, exosomes derived from CA-MSCs; NC, negative
control; inh, inhibitor.

Figure 3

miR-182 knockdown attenuates the
effect of CA-MSC exosomes on non-small cell lung cancer cell
viability and invasiveness. Comparison of the (A) viability, (B)
number of invasive cells (magnification, ×200) and (C) apoptosis
rate of A549 cells in the Mock, Control Exo, NC-inh Exo and miR-inh
Exo groups. Comparison of the (D) viability, (E) number of invasive
cells (magnification, ×200) and (F) apoptosis rate of H1299 cells
in the Mock, Control Exo, NC-inh Exo and miR-inh Exo groups.
*P<0.05, **P<0.01 and ***P<0.001; ns, no significance.
miR-182, microRNA-182; Exo, exosomes; NC, negative control; inh,
inhibitor.

Figure 4

miR-182-knockdown CA-MSC exosomes
increase FBXW7 expression in non-small cell lung cancer cells.
Comparison of (A) gene and (B) protein expression of FBXW7 in A549
cells in the Mock, Control Exo, NC-inh Exo and miR-inh Exo groups.
Comparison of (C) gene and (D) protein expression of FBXW7 in H1299
cells in the Mock, Control Exo, NC-inh Exo and miR-inh Exo groups.
*P<0.05 and **P<0.01; ns, no significance. miR-182,
microRNA-182; Exo, exosomes; NC, negative control; inh, inhibitor;
FBXW7, F-box and WD repeat domain containing 7.

Figure 5

miR-182 mimic and FBXW7 OE vector
modifies FBXW7 expression in non-small cell lung cancer cells.
Comparison of (A) gene and (B) protein expression of FBXW7 in A549
cells in the Mock, Scramble, miR-mimic, OE-FBXW7 and miR-mimic +
OE-FBXW7 groups. Comparison of (C) gene and (D) protein expression
of FBXW7 in H1299 cells in the Mock, Scramble, miR-mimic, OE-FBXW7
and miR-mimic + OE-FBXW7 groups. *P<0.05, **P<0.01 and
***P<0.001; ns, no significance. miR-182, microRNA-182; FBXW7,
F-box and WD repeat domain containing 7; OE, overexpression
(vector).

Figure 6

miR-182 mimic promotes non-small cell
lung cancer cell viability and invasiveness via targeting FBXW7.
Comparison of the (A) viability, (B) number of invasive cells
(magnification, ×200) and (C) apoptosis rate of A549 cells in the
Mock, Scramble, miR-mimic, OE-FBXW7 and miR-mimic + OE-FBXW7
groups. Comparison of the (D) viability, (E) number of invasive
cells (magnification, ×200) and (F) apoptosis rate of H1299 cells
in the Mock, Scramble, miR-mimic, OE-FBXW7 and miR-mimic + OE-FBXW7
groups. *P<0.05, **P<0.01 and ***P<0.001; ns, no
significance. miR-182, microRNA-182; FBXW7, F-box and WD repeat
domain containing 7; OE, overexpression (vector).

Figure 7

miR-182 mimic and FBXW7 OE vector
modifies AKT and ERK signaling in non-small cell lung cancer cells.
Comparison of p-AKT and p-ERK1/2 expression levels in (A) A549 and
(B) H1299 cells in the Mock, Scramble, miR-mimic, OE-FBXW7 and
miR-mimic + OE-FBXW7 groups. p-ERK1/2 was analyzed using ERK1/2 as
a reference control, p-AKT was analyzed using AKT as a reference
control, and the loading control (GAPDH) was set to ensure that the
loading amount of all samples was consistent. *P<0.05 and
**P<0.01; ns, no significance. miR-182, microRNA-182; FBXW7,
F-box and WD repeat domain containing 7; OE, overexpression
(vector); p-, phosphorylated.
View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI

2 

Han B, Zheng R, Zeng H, Wang S, Sun K, Chen R, Li L, Wei W and He J: Cancer incidence and mortality in China, 2022. J Natl Cancer Cent. 4:47–53. 2024.PubMed/NCBI

3 

Chen P, Liu Y, Wen Y and Zhou C: Non-small cell lung cancer in China. Cancer Commun (Lond). 42:937–970. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Alexander M, Kim SY and Cheng H: Update 2020: Management of non-small cell lung cancer. Lung. 198:897–907. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Wu J and Lin Z: Non-small cell lung cancer targeted therapy: Drugs and mechanisms of drug resistance. Int J Mol Sci. 23:150562022. View Article : Google Scholar : PubMed/NCBI

6 

Wang KH and Ding DC: Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review. Tzu Chi Med J. 35:24–30. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Frisbie L, Buckanovich RJ and Coffman L: Carcinoma-associated mesenchymal stem/stromal cells: Architects of the pro-tumorigenic tumor microenvironment. Stem Cells. 40:705–715. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Adelipour M, Lubman DM and Kim J: Potential applications of mesenchymal stem cells and their derived exosomes in regenerative medicine. Expert Opin Biol Ther. 23:491–507. 2023. View Article : Google Scholar : PubMed/NCBI

9 

Papaccio F, Paino F, Regad T, Papaccio G, Desiderio V and Tirino V: Concise review: Cancer cells, cancer stem cells, and mesenchymal stem cells: Influence in cancer development. Stem Cells Transl Med. 6:2115–2125. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Arena S, Salati M, Sorgentoni G, Barbisan F and Orciani M: Characterization of tumor-derived mesenchymal stem cells potentially differentiating into cancer-associated fibroblasts in lung cancer. Clin Transl Oncol. 20:1582–1591. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Hazrati A, Malekpour K, Mirsanei Z, Khosrojerdi A, Rahmani-Kukia N, Heidari N, Abbasi A and Soudi S: Cancer-associated mesenchymal stem/stromal cells: Role in progression and potential targets for therapeutic approaches. Front Immunol. 14:12806012023. View Article : Google Scholar : PubMed/NCBI

12 

Shang C, Ke M, Liu L, Wang C, Liu Y and Zheng X: Exosomes from cancer-associated mesenchymal stem cells transmit TMBIM6 to promote the malignant behavior of hepatocellular carcinoma via activating PI3K/AKT pathway. Front Oncol. 12:8687262022. View Article : Google Scholar : PubMed/NCBI

13 

Garnier D, Ratcliffe E, Briand J, Cartron PF, Oliver L and Vallette FM: The activation of mesenchymal stem cells by glioblastoma microvesicles alters their exosomal secretion of miR-100-5p, miR-9-5p and let-7d-5p. Biomedicines. 10:1122022. View Article : Google Scholar : PubMed/NCBI

14 

Zhao MN, Zhang LF, Sun Z, Qiao LH, Yang T, Ren YZ, Zhang XZ, Wu L, Qian WL, Guo QM, et al: A novel microRNA-182/interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer. Cell Death Dis. 14:2982023. View Article : Google Scholar : PubMed/NCBI

15 

Yang F, Pei Y, Xu W and Rong L: hsa_circ_0003176 suppresses the progression of non-small-cell lung cancer via regulating miR-182-5p/RBM5 axis. Dis Markers. 2022:84021162022. View Article : Google Scholar : PubMed/NCBI

16 

Yang W, Yin Y, Bi L, Wang Y, Yao J, Xu L and Jiao L: MiR-182-5p promotes the metastasis and epithelial-mesenchymal transition in non-small cell lung cancer by targeting EPAS1. J Cancer. 12:7120–7129. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Stafford MYC and McKenna DJ: MiR-182 is upregulated in prostate cancer and contributes to tumor progression by targeting MITF. Int J Mol Sci. 24:18242023. View Article : Google Scholar : PubMed/NCBI

18 

Li J, Yuan H, Xu H, Zhao H and Xiong N: Hypoxic cancer-secreted exosomal miR-182-5p promotes glioblastoma angiogenesis by targeting kruppel-like factor 2 and 4. Mol Cancer Res. 18:1218–1231. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Gao F, Yin J, Wang Y, Li H and Wang D: miR-182 promotes cervical cancer progression via activating the Wnt/β-catenin axis. Am J Cancer Res. 13:3591–3598. 2023.PubMed/NCBI

20 

Chen G, Yu L, Dong H, Liu Z and Sun Y: MiR-182 enhances radioresistance in non-small cell lung cancer cells by regulating FOXO3. Clin Exp Pharmacol Physiol. 46:137–143. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Cascio S, Chandler C, Zhang L, Sinno S, Gao B, Onkar S, Bruno TC, Vignali DAA, Mahdi H, Osmanbeyoglu HU, et al: Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition. Sci Adv. 7:eabi57902021. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Cao J, Yu U, Li L, Yuan X, Chen S, Xu H, Yi M and Liu S: circKL inhibits the growth and metastasis of kidney cancer by sponging miR-182-5p and upregulating FBXW7. Oncol Rep. 47:752022. View Article : Google Scholar : PubMed/NCBI

24 

Chang H, Liu YH, Wang LL, Wang J, Zhao ZH, Qu JF and Wang SF: MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer. Am J Transl Res. 10:1131–1142. 2018.PubMed/NCBI

25 

Chiang CH, Chu PY, Hou MF and Hung WC: MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7. Am J Cancer Res. 6:1785–1798. 2016.PubMed/NCBI

26 

Razmkhah M, Abtahi S and Ghaderi A: Mesenchymal stem cells, immune cells and tumor cells crosstalk: A sinister triangle in the tumor microenvironment. Curr Stem Cell Res Ther. 14:43–51. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Bussard KM, Mutkus L, Stumpf K, Gomez-Manzano C and Marini FC: Tumor-associated stromal cells as key contributors to the tumor microenvironment. Breast Cancer Res. 18:842016. View Article : Google Scholar : PubMed/NCBI

28 

Liu H, Deng S, Han L, Ren Y, Gu J, He L, Liu T and Yuan ZX: Mesenchymal stem cells, exosomes and exosome-mimics as smart drug carriers for targeted cancer therapy. Colloids Surf B Biointerfaces. 209:1121632022. View Article : Google Scholar : PubMed/NCBI

29 

Gemayel J, Chaker D, El Hachem G, Mhanna M, Salemeh R, Hanna C, Harb F, Ibrahim A, Chebly A and Khalil C: Mesenchymal stem cells-derived secretome and extracellular vesicles: Perspective and challenges in cancer therapy and clinical applications. Clin Transl Oncol. 25:2056–2068. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Yan C, Chang J, Song X, Qi Y, Ji Z, Liu T, Yu W, Wei F, Yang L and Ren X: Lung cancer-associated mesenchymal stem cells promote tumor metastasis and tumorigenesis by induction of epithelial-mesenchymal transition and stem-like reprogram. Aging (Albany NY). 13:9780–9800. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Yassine S and Alaaeddine N: Mesenchymal stem cell exosomes and cancer: Controversies and prospects. Adv Biol (Weinh). 6:e21010502022. View Article : Google Scholar : PubMed/NCBI

32 

Lin Z, Wu Y, Xu Y, Li G, Li Z and Liu T: Mesenchymal stem cell-derived exosomes in cancer therapy resistance: Recent advances and therapeutic potential. Mol Cancer. 21:1792022. View Article : Google Scholar : PubMed/NCBI

33 

Wu X, Wang W, Wu G, Peng C and Liu J: miR-182-5p serves as an oncogene in lung adenocarcinoma through binding to STARD13. Comput Math Methods Med. 2021:70743432021. View Article : Google Scholar : PubMed/NCBI

34 

Zhang T, Goel A, Xu X, Wu Y, Tang E, Zhang F, Li Y, Li H, Cai Y and Weng W: N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas. Lung Cancer. 171:70–81. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Zhao J, Tang J, Men W and Ren K: FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells. FEBS Lett. 586:4257–4263. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Xiao G, Li Y, Wang M, Li X, Qin S, Sun X, Liang R, Zhang B, Du N, Xu C, et al: FBXW7 suppresses epithelial-mesenchymal transition and chemo-resistance of non-small-cell lung cancer cells by targeting snai1 for ubiquitin-dependent degradation. Cell Prolif. 51:e124732018. View Article : Google Scholar : PubMed/NCBI

37 

An HJ, Lee CJ, Lee GE, Choi Y, Jeung D, Chen W, Lee HS, Kang HC, Lee JY, Kim DJ, et al: FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells. Exp Mol Med. 54:35–46. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Li C, Lin XF, Wang JN and Ren XS: FBXW7 inhibited cell proliferation and invasion regulated by miR-27a through PI3K/AKT signaling pathway and epithelial-to-mesenchymal transition in oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 24:3701–3709. 2020.PubMed/NCBI

39 

Pan Y, Liu J, Gao Y, Guo Y, Wang C, Liang Z, Wu M, Qian Y, Li Y, Shen J, et al: FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation. J Exp Clin Cancer Res. 42:752023. View Article : Google Scholar : PubMed/NCBI

40 

Song M, Bode AM, Dong Z and Lee MH: AKT as a therapeutic target for cancer. Cancer Res. 79:1019–1031. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Ullah R, Yin Q, Snell AH and Wan L: RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol. 85:123–154. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Zhu X, Yu L, Dong H and Liu Z: Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway. Oncol Lett 30: 487, 2025.
APA
Sun, Y., Zhu, X., Yu, L., Dong, H., & Liu, Z. (2025). Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway. Oncology Letters, 30, 487. https://doi.org/10.3892/ol.2025.15233
MLA
Sun, Y., Zhu, X., Yu, L., Dong, H., Liu, Z."Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway". Oncology Letters 30.4 (2025): 487.
Chicago
Sun, Y., Zhu, X., Yu, L., Dong, H., Liu, Z."Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway". Oncology Letters 30, no. 4 (2025): 487. https://doi.org/10.3892/ol.2025.15233
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Zhu X, Yu L, Dong H and Liu Z: Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway. Oncol Lett 30: 487, 2025.
APA
Sun, Y., Zhu, X., Yu, L., Dong, H., & Liu, Z. (2025). Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway. Oncology Letters, 30, 487. https://doi.org/10.3892/ol.2025.15233
MLA
Sun, Y., Zhu, X., Yu, L., Dong, H., Liu, Z."Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway". Oncology Letters 30.4 (2025): 487.
Chicago
Sun, Y., Zhu, X., Yu, L., Dong, H., Liu, Z."Cancer‑associated mesenchymal stem cell exosomes facilitate non‑small cell lung cancer cell viability and invasiveness&nbsp;<br />by delivering miR‑182 in a FBXW7‑related AKT and ERK‑dependent pathway". Oncology Letters 30, no. 4 (2025): 487. https://doi.org/10.3892/ol.2025.15233
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team