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Review Open Access

The role of NR2F2 in cancer (Review)

  • Authors:
    • Zi-Ning Liu
    • Xiao Yang
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    Affiliations: Laboratory of Pathophysiology, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China, Department of Neurorehabilitation, Shengli Oilfield Central Hospital, Dongying, Shandong 257000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 493
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    Published online on: August 21, 2025
       https://doi.org/10.3892/ol.2025.15239
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Abstract

The incidence and mortality rates of tumors continue to show an annual upward trend. Since its discovery in 1986, nuclear receptor subfamily 2, group F, member 2 (NR2F2) has been shown to serve a key role in the transcriptional regulation of various genes. Furthermore, NR2F2 has a notable impact on the progression of tumors; however, its role in tumor progression it not yet fully understood. Multi‑omics can illuminate the paradoxical roles of NR2F2 across various malignancies, where it functions as either an oncogenic driver or tumor suppressor in a context‑dependent manner. The present review discusses the determinant influence of NR2F2 in modulating disease advancement and mechanisms in heterogeneous types of cancer, including its effects on tumor proliferation, apoptosis and epithelial‑mesenchymal transition. The aim was to assess the role and mechanisms of NR2F2 in various tumors, identify its clinical utility in targeted cancer therapy and thereby provide a novel therapeutic option for overcoming cancer.
View Figures

Figure 1

The mechanism and regulatory network
through which NR2F2 exerts its functions in cancer development and
progression. NR2F2, nuclear receptor subfamily 2, group F, member
2; CCND1, cyclin D1; NEK2, nucleolar and spindle-associated protein
2; RAI14, retinoic acid induced 14; EMT, epithelial-mesenchymal
transition; miRNA/miR, microRNA; ceRNA, competing endogenous RNA;
lncRNA, long non-coding RNA; AS1, antisense 1.

Figure 2

Panoramic model of the core
regulatory network of NR2F2. NR2F2, nuclear receptor subfamily 2,
group F, member 2; EMT, epithelial-mesenchymal transition;
miRNA/miR, microRNA; lncRNA, long non-coding RNA; NEK2, nucleolar
and spindle-associated protein 2; ZEB1, zinc finger E-box-binding
homeobox 1; cad, cadherin; p, phosphorylated; CDK4, cyclin
dependent kinase; AS1, antisense 1; Iso, isoform.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z and Yang X: The role of NR2F2 in cancer (Review). Oncol Lett 30: 493, 2025.
APA
Liu, Z., & Yang, X. (2025). The role of NR2F2 in cancer (Review). Oncology Letters, 30, 493. https://doi.org/10.3892/ol.2025.15239
MLA
Liu, Z., Yang, X."The role of NR2F2 in cancer (Review)". Oncology Letters 30.5 (2025): 493.
Chicago
Liu, Z., Yang, X."The role of NR2F2 in cancer (Review)". Oncology Letters 30, no. 5 (2025): 493. https://doi.org/10.3892/ol.2025.15239
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z and Yang X: The role of NR2F2 in cancer (Review). Oncol Lett 30: 493, 2025.
APA
Liu, Z., & Yang, X. (2025). The role of NR2F2 in cancer (Review). Oncology Letters, 30, 493. https://doi.org/10.3892/ol.2025.15239
MLA
Liu, Z., Yang, X."The role of NR2F2 in cancer (Review)". Oncology Letters 30.5 (2025): 493.
Chicago
Liu, Z., Yang, X."The role of NR2F2 in cancer (Review)". Oncology Letters 30, no. 5 (2025): 493. https://doi.org/10.3892/ol.2025.15239
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