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Case Report Open Access

Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report

  • Authors:
    • Liangxue Zhu
    • Yajun Xing
    • Mingyun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Nanjing Gaochun People's Hospital, Jiangsu, Nanjing 211300, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 496
    |
    Published online on: August 25, 2025
       https://doi.org/10.3892/ol.2025.15242
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Abstract

Triple‑negative invasive lobular carcinoma (TN‑ILC) is a rare and highly aggressive subtype of breast cancer. The development of gastric metastases in breast cancer is extremely rare and typically occurs several years after initial diagnosis. The present case report describes a 68‑year‑old postmenopausal female patient who presented with TN‑ILC with gastric metastases at initial diagnosis. This metastatic pattern is very rare and is often mistaken for primary gastric cancer, which poses a notable diagnostic challenge. Imaging and histopathological analyses confirmed typical TN‑ILC features (estrogen receptor negative, progesterone receptor negative and HER‑2 1+ positive) and revealed diffuse metastases to the gastric wall, brain, bone, adrenal glands, pleura and lymph nodes. Gastric metastases from breast cancer were further confirmed by immunohistochemical studies, including for GATA binding protein 3, Villin and cytokeratin 7/20. It is noteworthy that the patient exhibited no gastrointestinal symptoms, which could have led to a missed diagnosis. The present case underscores the significance of a comprehensive evaluation in metastatic breast cancer.
View Figures

Figure 1

(A) Chest CT demonstrating a left
breast mass (arrow) with localized skin thickening and left pleural
effusion. (B) The gastric wall was thickened with enlarged
perigastric lymph nodes. (C) Metastatic nodules of the adrenal
gland. (D) Cerebral metastases in the left occipital lobes. (E)
Multiple metastases in the spine and vertebral body attachments.
(F) Stable disease of breast cancer after two cycles of first-line
chemotherapy. (G) Disease progression of breast cancer. (H) New
intracranial metastases on the right side of the brain. White
arrows indicate tumor location in all images.

Figure 2

(A) Endoscopic view revealing
congested, edematous gastric mucosa with infiltrative lesions,
characterized by rigid folds and surface erosions. (B) HE staining
of breast biopsy tissue showing characteristic invasive lobular
carcinoma morphology (magnification, ×10). (C) HE staining of
gastric biopsy tissue showing adenocarcinoma (magnification, ×10).
HE, hematoxylin and eosin.

Figure 3

Immunohistochemistry results of the
breast biopsy specimen (magnification, ×100). Staining for (A) ER,
(B) PR, (C) HER-2, (D) E-cadherin, (E) Ki-67, (F) β-catenin, (G)
CK5/6, (H) CK14 and (I) AR. ER, estrogen receptor; PR, progesterone
receptor; CK, cytokeratin; AR, androgen receptor.

Figure 4

Immunohistochemistry results of the
gastric biopsy specimen (magnification, ×100). (A) ER, (B) HER-2,
(C) CK7, (D) GATA-3, (E) Villin and (F) CK20. ER, estrogen
receptor; PR, progesterone receptor; CK, cytokeratin; GATA-3, GATA
binding protein 3.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Xing Y and Wang M: Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report. Oncol Lett 30: 496, 2025.
APA
Zhu, L., Xing, Y., & Wang, M. (2025). Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report. Oncology Letters, 30, 496. https://doi.org/10.3892/ol.2025.15242
MLA
Zhu, L., Xing, Y., Wang, M."Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report". Oncology Letters 30.5 (2025): 496.
Chicago
Zhu, L., Xing, Y., Wang, M."Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report". Oncology Letters 30, no. 5 (2025): 496. https://doi.org/10.3892/ol.2025.15242
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Xing Y and Wang M: Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report. Oncol Lett 30: 496, 2025.
APA
Zhu, L., Xing, Y., & Wang, M. (2025). Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report. Oncology Letters, 30, 496. https://doi.org/10.3892/ol.2025.15242
MLA
Zhu, L., Xing, Y., Wang, M."Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report". Oncology Letters 30.5 (2025): 496.
Chicago
Zhu, L., Xing, Y., Wang, M."Triple‑negative invasive lobular carcinoma presenting with synchronous gastric metastasis: A case report". Oncology Letters 30, no. 5 (2025): 496. https://doi.org/10.3892/ol.2025.15242
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