Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2025 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2025 Volume 30 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer 
in the era of immunotherapy

  • Authors:
    • Meiqiao Jiang
    • Lihua Shao
    • Yuanzhaoyun Long
    • Jinning Sun
    • Shihong Wei
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730030, P.R. China, Department of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, Gansu 730050, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 518
    |
    Published online on: September 9, 2025
       https://doi.org/10.3892/ol.2025.15264
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Synergistic antitumor effects of thoracic radiotherapy (TRT) are still debated due to conflicting clinical evidence. The aim of the present meta‑analysis was to evaluate the efficacy and safety of chemo‑immunotherapy combined with TRT in extensive‑stage small cell lung cancer (ES‑SCLC). CNKI, Wanfang, VIP, Pubmed, Embase and the Cochrane library were searched for published literature on chemo‑immunotherapy combined with TRT for ES‑SCLC between January 1, 2018, and March 4, 2024. After screening the studies and extracting data according to the inclusion criteria, Review Manager 5.4 and Stata 15 were used to assess the risk of bias of the studies and perform a meta‑analysis of the data. A total of 19 relevant prospective and retrospective clinical research articles were included, involving 1,557 patients. The results of the meta‑analysis demonstrated that, in terms of efficacy, chemo‑immunotherapy combined with TRT significantly improves overall survival [OS; hazard ratio (HR)=0.49; 95% confidence interval, (CI), 0.34‑0.71; P<0.05] and progression‑free survival (PFS; HR=0.62; 95% CI, 0.51‑0.76; P<0.05) of patients with ES‑SCLC. Sub‑group analysis indicated that primary liver metastasis was an independent predictor of poor OS (HR=2.45; 95% CI, 1.84‑3.25; P<0.05), and TRT was a favorable predictor of OS (HR=0.44; 95% CI, 0.21‑0.96; P<0.05) and PFS (HR=0.59; 95% CI, 0.47‑0.76; P<0.05). In terms of safety, the incidence of grade ≥3 adverse reactions in the chemo‑immunotherapy/TRT combination group was significantly higher than that in the chemo‑immunotherapy group (risk ratio=1.30; 95% CI, 1.02‑1.66; P<0.05). The most common adverse reactions in the chemo‑immunotherapy/TRT combination group were radiation pneumonitis (27%; 95% CI, 14‑41%), radiation esophagitis (17%; 95% CI, 9‑25%) and thrombocytopenia (9%; 95% CI, 5‑14%). In conclusion, chemo‑immunotherapy combined with TRT demonstrated improved survival outcomes in patients with ES‑SCLC, with acceptable toxicity profiles. However, further validation through prospective clinical trials is warranted.
View Figures

Figure 1

Median progression-free survival in
comparative studies. CI, confidence interval; SE, standard
error.

Figure 2

Median overall survival in
comparative studies. CI, confidence interval; SE, standard
error.

Figure 3

Treatment-related advert events of ≥3
grade in comparative studies. CI, confidence interval. M-H,
mantel-haenszel.

Figure 4

Pooled rate of radiation pneumonitis.
CI, confidence interval; ES, effect size.

Figure 5

Pooled rate of radiation esophagitis.
CI, confidence interval; ES, effect size.

Figure 6

Pooled rate of thrombocytopenia. CI,
confidence interval; ES, effect size.

Figure 7

Comparative study of overall survival
in patients with or without primary liver metastasis. CI,
confidence interval; SE, standard error.

Figure 8

Comparative study of OS and PFS in
patients with or without TRT. OS, overall survival; PFS,
progression-free survival; TRT, thoracic radiotherapy; CI,
confidence interval; SE, standard error.

Figure 9

Funnel plot for overall survival. SE,
standard error.

Figure 10

Sensitivity analysis. (A) Scatter
plot for sensitivity analysis of OS. (B) Forest map of sensitivity
analysis of OS. OS, overall survival; CI, confidence interval; SE,
standard error.
View References

1 

George J, Maas L, Abedpour N, Cartolano M, Kaiser L, Fischer RN, Scheel AH, Weber JP, Hellmich M, Bosco G, et al: Evolutionary trajectories of small cell lung cancer under therapy. Nature. 627:880–889. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Roviello G, Zanotti L, Cappelletti MR, Gobbi A, Senti C, Bottini A and Generali D: No advantage in survival with targeted therapies as maintenance in patients with limited and extensive-stage small cell lung cancer: A literature-based meta-analysis of randomized trials. Clin Lung Cancer. 17:334–340. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, et al: First-line atezolizumab plus chemotherapy in extensive-stage small-cell lung cancer. N Engl J Med. 379:2220–2229. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Liu SV, Reck M, Mansfield AS, Mok T, Scherpereel A, Reinmuth N, Garassino MC, De Castro Carpeno J, Califano R, Nishio M, et al: Updated overall survival and PD-L1 subgroup analysis of patients with extensive-stage small-cell lung cancer treated with atezolizumab, carboplatin, and etoposide (IMpower133). J Clin Oncol. 39:619–630. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Goldman JW, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, et al: Durvalumab, with or without tremelimumab, plus platinum–etoposide vs. platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): Updated results from a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 22:51–65. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, et al: Durvalumab plus platinum-etoposide vs. platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): A randomised, controlled, open-label, phase 3 trial. Lancet. 394:1929–1939. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Cheng Y, Han L, Wu L, Chen J, Sun H, Wen G, Ji Y, Dvorkin M, Shi J, Pan Z, Shi J, Wang X, Bai Y, Melkadze T, Pan Y, et al: Effect of first-line serplulimab vs. placebo added to chemotherapy on survival in patients with extensive-stage small cell lung cancer: The ASTRUM-005 randomized clinical trial. JAMA. 328:1223–1232. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Kim D, Kim HJ, Wu HG, Lee JH, Kim S, Kim TM, Kim JS and Kim BH: Intrathoracic progression is still the most dominant failure pattern after first-line chemo-immunotherapy in extensive-stage small-cell lung cancer: Implications for thoracic radiotherapy. Cancer Res Treat. 56:430–441. 2024. View Article : Google Scholar : PubMed/NCBI

9 

Jeremic B, Shibamoto Y, Nikolic N, Milicic B, Milisavljevic S, Dagovic A, Aleksandrovic J and Radosavljevic-Asic G: Role of radiation therapy in the combined-modality treatment of patients with extensive disease small-cell lung cancer: A randomized study. J Clin Oncol. 17:2092–2099. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Gore EM, Hu C, Sun AY, Grimm DF, Ramalingam SS, Dunlap NE, Higgins KA, Werner-Wasik M, Allen AM, Iyengar P, et al: Randomized phase II study comparing prophylactic cranial irradiation alone to prophylactic cranial irradiation and consolidative extracranial irradiation for extensive-disease small cell lung cancer (ED SCLC): NRG oncology RTOG 0937. J Thorac Oncol. 12:1561–15670. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Slotman BJ, van Tinteren H, Praag JO, Knegjens JL, El Sharouni SY, Hatton M, Keijser A, Faivre-Finn C and Senan S: Use of thoracic radiotherapy for extensive stage small-cell lung cancer: A phase 3 randomised controlled trial. Lancet. 385:36–42. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Lo CK, Mertz D and Loeb M: Newcastle-Ottawa Scale: Comparing reviewers' to authors' assessments. BMC Med Res Methodol. 14:452014. View Article : Google Scholar : PubMed/NCBI

13 

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y and Chipponi J: Methodological index for non-randomized studies (minors): Development and validation of a new instrument. ANZ J Surg. 73:712–716. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Cumpston M and Flemyng E. Chapter IV: Updating a review [last updated August 2023]. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ and Welch VA: Cochrane handbook for systematic reviews of interventions. Version 6.5 (updated August 2024). Cochrane; 2024, www.training.cochrane.org/handbookJune 24–2024PubMed/NCBI

15 

Wu JJ, Huang JW, Hsu KH, Huang YH, Chen KC, Tseng JS, Yang TY and Chang GC: Thoracic radiotherapy may improve the outcome of extensive stage small cell lung carcinoma patients treated with first-line immunotherapy plus chemotherapy. Anticancer Drugs. 33:e842–e849. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Siegel RL, Miller KD and Wagle NS: Cancer statistics, 2023. CA: A Cancer J Clin. 73:17–48. 2023.PubMed/NCBI

17 

Farago AF and Keane FK: Current standards for clinical management of small cell lung cancer. Transl Lung Cancer Res. 7:69–79. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Oronsky B, Reid TR, Oronsky A and Carter CA: What's new in SCLC? A review. Neoplasia. 19:842–847. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Barrows ED, Blackburn MJ and Liu SV: Evolving role of immunotherapy in small cell lung cancer. Semin Cancer Biol. 86:868–874. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Li H, Zhao Y, Ma T, Shao H, Wang T, Jin S and Liu Z: Radiotherapy for extensive-stage small-cell lung cancer in the immunotherapy era. Front Immunol. 14:11324822023. View Article : Google Scholar : PubMed/NCBI

21 

Chen X, Sheikh K, Nakajima E, Lin CT, Lee J, Hu C, Hales RK, Forde PM, Naidoo J and Voong KR: Radiation versus immune checkpoint inhibitor associated pneumonitis: Distinct radiologic morphologies. Oncologist. 26:e1822–e1832. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Diamond BH, Verma N, Shukla UC, Park HS and Koffer PP: Consolidative thoracic radiation therapy after first-line chemotherapy and immunotherapy in extensive-stage small cell lung cancer: A multi-institutional case series. Adv Radiat Oncol. 7:1008832022. View Article : Google Scholar : PubMed/NCBI

23 

Fang M, Wang L, Gu Q, Wu H, Du X and Lai X: Efficacy and safety of thoracic radiotherapy for extensive stage small cell lung cancer after immunotherapy in real world. Clin Exp Metastasis. 40:423–429. 2023. View Article : Google Scholar : PubMed/NCBI

24 

Li Y, Jing W, Jing X, Sun Y, Tang X, Guo J, Zhang Y and Zhu H: Role of consolidative thoracic radiation in extensive-stage small-cell lung cancer with first-line chemo-immunotherapy: A retrospective study from a single cancer center. Discov Oncol. 14:552023. View Article : Google Scholar : PubMed/NCBI

25 

Lindblad KE and Lujambio A: Liver metastases inhibit immunotherapy efficacy. Nat Med. 27:25–27. 2021. View Article : Google Scholar : PubMed/NCBI

26 

O'leary K: Liver metastases cultivate an immune desert. Nat Rev Cancer. 21:1432021. View Article : Google Scholar : PubMed/NCBI

27 

Fan L, Lin Y, Fu Y and Wang J: Small cell lung cancer with liver metastases: From underlying mechanisms to treatment strategies. Cancer Metastasis Rev. 44:52024. View Article : Google Scholar : PubMed/NCBI

28 

Slotman B, Faivre-Finn C, Kramer G, Rankin E, Snee M, Hatton M, Postmus P, Collette L, Musat E and Senan S; EORTC Radiation Oncology Group and Lung Cancer Group, : Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 357:664–672. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Perez BA, Kim S, Wang M, Karimi AM, Powell C, Li J, Dilling TJ, Chiappori A, Latifi K, Rose T, et al: Prospective single-arm phase 1 and 2 study: ipilimumab and nivolumab with thoracic radiation therapy after platinum chemotherapy in extensive-stage small cell lung cancer. Int J Radiat Oncol Biol Phys. 109:425–435. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Longo V, Della Corte CM, Russo A, Spinnato F, Ambrosio F, Ronga R, Marchese A, Del Giudice T, Sergi C, Casaluce F, et al: Consolidative thoracic radiation therapy for extensive-stage small cell lung cancer in the era of first-line chemo-immunotherapy: Preclinical data and a retrospective study in Southern Italy. Front Immunol. 14:12894342024. View Article : Google Scholar : PubMed/NCBI

31 

Yao Y, Li B, Song R, Yang L, Zou B and Wang L: Efficacy and safety of thoracic radiotherapy in extensive-stage small-cell lung cancer patients receiving first-line immunotherapy plus chemotherapy: A propensity score matched multicentre retrospective analysis. Radiat Oncol. 19:252024. View Article : Google Scholar : PubMed/NCBI

32 

Li L, Yang D, Min Y, Liao A, Zhao J, Jiang L, Dong X, Deng W, Yu H, Yu R, Zhao J and Shi A: First-line atezolizumab/durvalumab plus platinum–etoposide combined with radiotherapy in extensive-stage small-cell lung cancer. BMC Cancer. 23:3182023. View Article : Google Scholar : PubMed/NCBI

33 

Hoffmann E, De-Colle C, Potkrajcic V, Baumann D, Spengler W, Gani C and Utz D: Is consolidative thoracic radiotherapy of extensive-stage small cell lung cancer still beneficial in the era of immunotherapy? A retrospective analysis. Strahlenther Onkol. 199:668–675. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Welsh JW, Heymach JV, Chen D, Verma V, Cushman TR, Hess KR, Shroff G, Tang C, Skoulidis F, Jeter M, et al: Phase I trial of pembrolizumab and radiation therapy after induction chemotherapy for extensive-stage small cell lung cancer. J Thorac Oncol. 15:266–273. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Xie Z, Liu J, Wu M, Wang X, Lu Y, Han C, Cong L, Li J and Meng X: Real-world efficacy and safety of thoracic radiotherapy after first-line chemo-immunotherapy in extensive-stage small-cell lung cancer. J Clin Med. 12:38282023. View Article : Google Scholar : PubMed/NCBI

36 

Peng J, Zhang L, Wang L, Feng H, Yao D, Meng R, Liu X, Li X, Liu N, Tan B, et al: Real-world outcomes of PD-L1 inhibitors combined with thoracic radiotherapy in the first-line treatment of extensive stage small cell lung cancer. Radiat Oncol. 18:1112023. View Article : Google Scholar : PubMed/NCBI

37 

Liu W, Han Z, Wang J, Zhang T, Chen D, Feng Q, Xiao Z, Lyu J, Wang X, Deng L, et al: Safety of thoracic radiotherapy followed by PD-1/PD-L1 inhibitors after induction therapy in extensive-stage small cell lung cancer. Chin J Radiat Oncol. 31:236–241. 2022.

38 

Chen D, Zou B, Meng X, Huang W, Shao Q, Tang X, Guo J, Hu X, Zhang Y, Fu L, et al: Safety and efficacy of SHR-1316 combined with chemotherapy and sequential chest radiotherapy as first-line therapy for extensive-stage small cell lung cancer (ES-SCLC): The results from a phase II single-arm trial. J Clin Oncol. 40 (Suppl):85632022. View Article : Google Scholar

39 

Gross AJ, Kharouta MZ, Podder TK, Choi S and Biswas T: Role of thoracic radiotherapy in extensive stage small cell lung cancer (ES-SCLC) in the immunotherapy era: A national hospital-based registry analysis. Int J Radiat Oncol Biol Phys. 111:e4662021. View Article : Google Scholar

40 

Daher S, Allen A, Rottenberg Y, Nasrallah H, Yosef L, Blumenfeld PA, Wollner M, Appel S, Nechushtan H, Moskovitz M, Bar J and Zer A: 144P Real-world data of consolidative radiotherapy for extensive stage (ES)-SCLC treated by chemo-immunotherapy (chemo-IO). Ann Oncol. 33:S99–S100. 2022. View Article : Google Scholar

41 

Cai Z, Gu X, Xie J, Cheng D, Chen J, Cheng J, Ye J and Lv T: Safety and efficacy of thoracic radiotherapy combined with chemo-immunotherapy in patients with extensive-stage small cell lung cancer: A multicenter retrospective analysis. Transl Lung Cancer Res. 12:1987–2000. 2023. View Article : Google Scholar : PubMed/NCBI

42 

Meng F W.: Clinical study of first-line chemotherapy and immunotherapy combined with thoracic radiotherapy for extensive-stage small cell lung cancer. Chin J Radiat Oncol. 33:110–115. 2024.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang M, Shao L, Long Y, Sun J and Wei S: Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy. Oncol Lett 30: 518, 2025.
APA
Jiang, M., Shao, L., Long, Y., Sun, J., & Wei, S. (2025). Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy. Oncology Letters, 30, 518. https://doi.org/10.3892/ol.2025.15264
MLA
Jiang, M., Shao, L., Long, Y., Sun, J., Wei, S."Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy". Oncology Letters 30.5 (2025): 518.
Chicago
Jiang, M., Shao, L., Long, Y., Sun, J., Wei, S."Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy". Oncology Letters 30, no. 5 (2025): 518. https://doi.org/10.3892/ol.2025.15264
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang M, Shao L, Long Y, Sun J and Wei S: Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy. Oncol Lett 30: 518, 2025.
APA
Jiang, M., Shao, L., Long, Y., Sun, J., & Wei, S. (2025). Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy. Oncology Letters, 30, 518. https://doi.org/10.3892/ol.2025.15264
MLA
Jiang, M., Shao, L., Long, Y., Sun, J., Wei, S."Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy". Oncology Letters 30.5 (2025): 518.
Chicago
Jiang, M., Shao, L., Long, Y., Sun, J., Wei, S."Meta‑analysis of the efficacy and safety of thoracic radiotherapy for extensive‑stage small cell lung cancer&nbsp;<br />in the era of immunotherapy". Oncology Letters 30, no. 5 (2025): 518. https://doi.org/10.3892/ol.2025.15264
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team