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Case Report Open Access

Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report

  • Authors:
    • Fuqian Zhao
    • Junling Han
    • Daofu Shen
    • Rong Yu
    • Hongmei Niu
    • Yan Hui
    • Lei Wang
  • View Affiliations / Copyright

    Affiliations: Medical Laboratory Center, Chifeng Municipal Hospital/Chifeng Clinical College, Inner Mongolia Medical University, Chifeng, Inner Mongolia Autonomous Region 024000, P.R. China, Clinical Laboratory, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Pharmaceutical Hi‑Tech Zone, Taizhou, Jiangsu 210029, P.R. China, Cancer Treatment Center, Chifeng Municipal Hospital/Chifeng Clinical College, Inner Mongolia Medical University, Chifeng, Inner Mongolia Autonomous Region 024000, P.R. China, Precision Medicine Sequencing Center, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 521
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    Published online on: September 12, 2025
       https://doi.org/10.3892/ol.2025.15267
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Abstract

Vaccines can stimulate an immune response. However, whether the use of chemotherapy drugs affects the body's production of antibodies after vaccination remains to be studied. This study reports the case of a 49‑year‑old female patient who first visited Chifeng City Hospital (Chifeng, China) in January 2021 who was likely naturally infected with hepatitis B virus (HBV) during administration of vincristine, doxorubicin and prednisone because the patient was diagnosed with acute lymphoblastic leukemia, recovered spontaneously and developed high levels of anti‑hepatitis B surface antibodies (anti‑HBs). Due to routine testing for hepatitis B during treatment, the test in February 2022 revealed that the hepatitis B antigen (HBsAg) level was 0.19 (positive). Subsequently, a peripheral blood hepatitis B virus nucleic acid test was performed and the results did not show amplification. In March 2022, the HBsAg quantitative result was 12.8 (positive). The following day, consolidation chemotherapy was performed with the cisplatin, oxaliplatin, doxorubicin, etoposide and tegafur regimen and vincristine treatment was administered in March 2022. In August 2022, the HBsAg quantitative result of the patient was <0.05 (negative) and the anti‑HB content was 982 IU/l; 2 days later methotrexate combined with pegaspargase treatment was administered. Overall, the present study showed that chemotherapy did not affect the production of anti‑HBs in the patient.
View Figures

Figure 1

Numerous primitive lymphocytes appear
in the bone marrow and peripheral blood. Bone marrow smears from
the patient in (A) 10× and (B) 40× magnification. The bone marrow
is hyperproliferative or markedly hyperproliferative, with
primitive and immature lymphocytes predominating at over 30%.
Erythrocytes, granulocytes, and megakaryocytes are markedly
decreased. (C) and (D) Peripheral blood smears in (C) 10× and (D)
40× magnification. Leukemic cells vary in size, with an increased
nuclear-cytoplasmic ratio and irregular nuclei that may be twisted
or folded. Nucleoli are prominent and numerous, with scant
cytoplasm. All smears were stained with Wright-Giemsa stain.

Figure 2

Changes in trends in peripheral
blood-related clinical diagnostic markers. (A) Detection of
hepatitis B markers HBsAg (IU/ml) and anti-Hbs (IU/l). (B)
Detection of ALT and AST levels (unit, IU/l). (C) Detection of ALP
and GGT levels (unit, IU/l). (D) Proportion of major immune cells;
(E) WBC (109/l); RBC (1012/l); Hb (g/l); PLT
(109/l) content determination. HBsAg, Hepatitis B
surface antigen; anti-Hbs, anti-hepatitis B surface antibodies;
ALT, alanine aminotransferase; AST, aspartate aminotransferase;
ALP, alkaline phosphatase; GGT, γ-glutamyl transferase; N,
neutrophils; L, lymphocytes; Mo, monocytes; WBC, white blood cell;
RBC, red blood cell; Hb, hemoglobin; PLT, platelet.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao F, Han J, Shen D, Yu R, Niu H, Hui Y and Wang L: Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report. Oncol Lett 30: 521, 2025.
APA
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., & Wang, L. (2025). Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report. Oncology Letters, 30, 521. https://doi.org/10.3892/ol.2025.15267
MLA
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., Wang, L."Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report". Oncology Letters 30.5 (2025): 521.
Chicago
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., Wang, L."Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report". Oncology Letters 30, no. 5 (2025): 521. https://doi.org/10.3892/ol.2025.15267
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao F, Han J, Shen D, Yu R, Niu H, Hui Y and Wang L: Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report. Oncol Lett 30: 521, 2025.
APA
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., & Wang, L. (2025). Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report. Oncology Letters, 30, 521. https://doi.org/10.3892/ol.2025.15267
MLA
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., Wang, L."Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report". Oncology Letters 30.5 (2025): 521.
Chicago
Zhao, F., Han, J., Shen, D., Yu, R., Niu, H., Hui, Y., Wang, L."Chemotherapy drugs do not affect the production of hepatitis B surface antibodies: A case report". Oncology Letters 30, no. 5 (2025): 521. https://doi.org/10.3892/ol.2025.15267
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