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Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review)

  • Authors:
    • Danfeng He
    • Yi Hu
    • Di Niu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The Eighth Hospital of Wuhan, Wuhan, Hubei 430013, P.R. China, Department of Dermatology and Venereology, The Eighth Hospital of Wuhan, Wuhan, Hubei 430013, P.R. China, Department of Otolaryngology, The Eighth Hospital of Wuhan, Wuhan, Hubei 430013, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 525
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    Published online on: September 16, 2025
       https://doi.org/10.3892/ol.2025.15271
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Abstract

The 14‑3‑3 family of proteins are phosphoserine/
phosphothreonine‑binding proteins. 14‑3‑3σ (SFN) is a subtype of the 14‑3‑3 family and is widely present in all tissues and organs of eukaryotes. SFN can regulate various biological activities, such as cell growth, cell division, cell death and cell migration, by binding to different client proteins. These diverse biological functions make SFN a candidate protein that may play a notable role in the development of various diseases. However, its mechanism of action remains unclear, and its role in different diseases is still controversial. DNA methylation is an important epigenetic modification. DNA methylation, under the catalysis of DNA‑related modification enzymes, affects gene expression regulation, including the silencing of tumor suppressor genes, oncogene activation, genome stability and the tumor microenvironment. In the present review, how SFN DNA methylation promotes or blocks the carcinogenesis and tumor progression of various cancer types is discussed. The potential clinical value of SFN as a tumor suppressor or cancer‑promoting factor in different cancer types for precision cancer medicine is also highlighted.
View Figures

Figure 1

Role of DNA methylation of SFN in
cancer. SFN, 14-3-3σ; BC, breast cancer; LC, lung cancer; KC,
kidney cancer; OC, ovarian cancer; NPC, nasopharyngeal cancer; SCC,
squamous cell carcinoma; GBC, gall blader cancer; PC, pancreatic
cancer; GC, gastric cancer; CRC, colorectal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
He D, Hu Y and Niu D: Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review). Oncol Lett 30: 525, 2025.
APA
He, D., Hu, Y., & Niu, D. (2025). Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review). Oncology Letters, 30, 525. https://doi.org/10.3892/ol.2025.15271
MLA
He, D., Hu, Y., Niu, D."Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review)". Oncology Letters 30.5 (2025): 525.
Chicago
He, D., Hu, Y., Niu, D."Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review)". Oncology Letters 30, no. 5 (2025): 525. https://doi.org/10.3892/ol.2025.15271
Copy and paste a formatted citation
x
Spandidos Publications style
He D, Hu Y and Niu D: Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review). Oncol Lett 30: 525, 2025.
APA
He, D., Hu, Y., & Niu, D. (2025). Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review). Oncology Letters, 30, 525. https://doi.org/10.3892/ol.2025.15271
MLA
He, D., Hu, Y., Niu, D."Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review)". Oncology Letters 30.5 (2025): 525.
Chicago
He, D., Hu, Y., Niu, D."Role and clinical significance of the DNA methylation of 14‑3‑3σ in cancer (Review)". Oncology Letters 30, no. 5 (2025): 525. https://doi.org/10.3892/ol.2025.15271
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