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Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma

  • Authors:
    • Liyang Yin
    • Yuanyuan Shi
    • Ruijia An
    • Yajing Hao
    • Haoran Huo
    • Jiadong Xue
    • Ruifeng Qin
    • Zengjiang Yuan
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Gynecology and Obstetrics, Handan Central Hospital, Handan, Hebei 056000, P.R. China, Department of Emergency Surgery, Handan Central Hospital, Handan, Hebei 056000, P.R. China
    Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 553
    |
    Published online on: September 25, 2025
       https://doi.org/10.3892/ol.2025.15299
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Abstract

Apatinib, an oral tyrosine kinase inhibitor, combined with camrelizumab, a programmed cell death protein 1 inhibitor, has shown promising treatment efficacy for patients with advanced hepatocellular carcinoma (HCC). However, real‑world evidence supporting this combination regimen is limited, and prognostic factors for these patients have not been thoroughly investigated. Therefore, the present real‑world study aimed to assess the efficacy and safety of camrelizumab plus apatinib in patients with advanced HCC, and identify prognostic factors associated with response to treatment. A total of 39 patients with advanced HCC who received camrelizumab combined with apatinib were included in the present retrospective study. All patient data, such as treatment response, follow‑up outcomes and incidence of adverse events were collected for analysis. The results revealed complete response, partial response, stable disease and progressive disease rates of 25.6, 10.3, 46.2 and 17.9%, respectively. In addition, the objective response and disease control rates were 35.9 and 82.1%, respectively. The median progression‑free survival (PFS) was 24.0 months (95% confidence interval, 5.0‑43.0). Furthermore, the cumulative PFS rates at 12, 24 and 36 months were 52.8, 44.0 and 39.1%, respectively. However, median overall survival (OS) was not reached during the follow‑up period. The OS rates at 12, 24 and 36 months were 72.4, 72.4 and 66.3%, respectively. Multivariate Cox regression analysis also revealed that extrahepatic metastasis was independently associated with higher mortality risk (hazard ratio, 9.217; P=0.049). The most common adverse events were anemia (79.5%), thrombocytopenia (69.2%), leukopenia (64.1%), pain (56.4%), neutropenia (41.0%), fever (33.3%) and hypertension (28.2%). In conclusion, camrelizumab combined with apatinib shows promising treatment efficacy and a manageable toxicity in patients with advanced HCC. Additionally, extrahepatic metastasis could be associated with worse OS in these patients. Nevertheless, due to the small sample size, retrospective and single‑arm study design in the current study, further study with a larger sample size, prospective, controlled design is required.
View Figures

Figure 1

Kaplan-Meier curves of PFS and OS in
patients with advanced hepatocellular carcinoma who received
camrelizumab plus apatinib. (A) Median (95% CI) PFS and
accumulating PFS rates at 12, 24, 36, 48 and 60 months in patients.
(B) The median (95% CI) OS and accumulating OS rates at 12, 24, 36,
48 and 60 months in patients. PFS, progression-free survival; OS,
overall survival; CI, confidence interval.
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Copy and paste a formatted citation
Spandidos Publications style
Yin L, Shi Y, An R, Hao Y, Huo H, Xue J, Qin R and Yuan Z: Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma. Oncol Lett 30: 553, 2025.
APA
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J. ... Yuan, Z. (2025). Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma. Oncology Letters, 30, 553. https://doi.org/10.3892/ol.2025.15299
MLA
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J., Qin, R., Yuan, Z."Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma". Oncology Letters 30.6 (2025): 553.
Chicago
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J., Qin, R., Yuan, Z."Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma". Oncology Letters 30, no. 6 (2025): 553. https://doi.org/10.3892/ol.2025.15299
Copy and paste a formatted citation
x
Spandidos Publications style
Yin L, Shi Y, An R, Hao Y, Huo H, Xue J, Qin R and Yuan Z: Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma. Oncol Lett 30: 553, 2025.
APA
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J. ... Yuan, Z. (2025). Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma. Oncology Letters, 30, 553. https://doi.org/10.3892/ol.2025.15299
MLA
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J., Qin, R., Yuan, Z."Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma". Oncology Letters 30.6 (2025): 553.
Chicago
Yin, L., Shi, Y., An, R., Hao, Y., Huo, H., Xue, J., Qin, R., Yuan, Z."Real‑world investigation for camrelizumab combined with apatinib in patients with advanced hepatocellular carcinoma". Oncology Letters 30, no. 6 (2025): 553. https://doi.org/10.3892/ol.2025.15299
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