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Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report

  • Authors:
    • Xiao-Chun Chen
    • Xian-Qin Li
    • Yi Liu
    • Xu Zhang
    • Chuan Lin
    • Zhi-Ping Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First People's Hospital of Yibin, Yibin, Sichuan 644000, P.R. China, Department of Pathology, The First People's Hospital of Yibin, Yibin, Sichuan 644000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 554
    |
    Published online on: September 25, 2025
       https://doi.org/10.3892/ol.2025.15300
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Abstract

Severe hepatic dysfunction and high performance status (PS) scores in patients with cancer often indicate a poor prognosis, with an estimated survival time of <3 months, making them typically candidates for palliative care. The current study presents the case of a 66‑year‑old male patient with prostate neuroendocrine carcinoma and diffuse hepatic metastasis, accompanied by severe hepatic dysfunction (Child‑Pugh C10) and poor PS (Eastern Cooperative Oncology Group PS3). The patient was treated with transarterial infusion chemotherapy (TAI) using a reduced‑dose etoposide and cisplatin regimen. After six cycles, significant tumor regression occurred. According to Response Evaluation Criteria in Solid Tumors 1.1 criteria, the response was a partial response. The patient finally succumbed, achieving a progression‑free survival time of 11.05 months and an overall survival time of 18.87 months. This case indicates that, for patients with sensitive and aggressive tumors (such as prostate neuroendocrine carcinoma) who have hepatic metastasis‑induced severe hepatic dysfunction and poor PS, local reduced‑dose TAI therapy may be a viable option to overcome traditional treatment contraindications.
View Figures

Figure 1

Diffuse hepatic metastasis in the
patient, suggestive of prostate neuroendocrine carcinoma. (A)
Coronal T1-weighted MR image showing diffuse nodular metastases in
the liver. (B) Computed tomography pulmonary window image showing a
metastatic lesion in the right middle lung (red arrow). (C) Axial
T1-weighted MR image showing a tumor protruding from the liver
surface, with retroperitoneal metastases in the red circle. (D)
Hematoxylin and eosin-stained histopathological image (×40
magnification). MR, magnetic resonance.

Figure 2

Comparison of efficacy in a patient
with prostate neuroendocrine carcinoma and diffuse hepatic
metastases. (A-C) Pretreatment: (A) Non-contrast T1-weighted, (B)
non-contrast T2-weighted and (C) contrast-enhanced T1-weighted
magnetic resonance images showing innumerable liver metastases.
(D-F) Post-treatment: Corresponding (D) Non-contrast T1-weighted,
(E) non-contrast T2-weighted and (F) contrast-enhanced T1-weighted
sequences demonstrating >30% reduction in hepatic tumor burden
consistent with a partial response.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Li X, Liu Y, Zhang X, Lin C and Yuan Z: Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report. Oncol Lett 30: 554, 2025.
APA
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., & Yuan, Z. (2025). Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report. Oncology Letters, 30, 554. https://doi.org/10.3892/ol.2025.15300
MLA
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., Yuan, Z."Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report". Oncology Letters 30.6 (2025): 554.
Chicago
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., Yuan, Z."Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report". Oncology Letters 30, no. 6 (2025): 554. https://doi.org/10.3892/ol.2025.15300
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Li X, Liu Y, Zhang X, Lin C and Yuan Z: Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report. Oncol Lett 30: 554, 2025.
APA
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., & Yuan, Z. (2025). Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report. Oncology Letters, 30, 554. https://doi.org/10.3892/ol.2025.15300
MLA
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., Yuan, Z."Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report". Oncology Letters 30.6 (2025): 554.
Chicago
Chen, X., Li, X., Liu, Y., Zhang, X., Lin, C., Yuan, Z."Transarterial infusion chemotherapy for severe hepatic dysfunction and poor performance status in diffuse hepatic metastasis: A case report". Oncology Letters 30, no. 6 (2025): 554. https://doi.org/10.3892/ol.2025.15300
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