|
1
|
Ferlay J, Shin HR, Bray F, Forman D,
Mathers C and Parkin DM: Estimates of worldwide burden of cancer in
2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ferlay J, Ervik M, Lam F, Colombet M, Mery
L, Pineros M, Znaor A, Soerjomataram I and Bray F: Global cancer
observatory: Cancer today. International Agency for Research on
Cancer. (Lyon, France). 2020.
|
|
3
|
Johnson DE, Burtness B, Leemans CR, Lui
VWY, Bauman JE and Grandis JR: Head and neck squamous cell
carcinoma. Nat Rev Dis Primers. 6:922020. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Aupérin A: Epidemiology of head and neck
cancers: An update. Curr Opin Oncol. 32:178–186. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
El-Naggar AK, Chan JKC, Grandis JR, Takata
T and Slootweg PJ: WHO classification of head and neck tumours.
International Agency for Research on Cancer; 2017
|
|
6
|
Lewis JS Jr, Beadle B, Bishop JA, Chernock
RD, Colasacco C, Lacchetti C, Moncur JT, Rocco JW, Schwartz MR,
Seethala RR, et al: Human papillomavirus testing in head and neck
carcinomas: Guideline from the college of american pathologists.
Arch Pathol Lab Med. 142:559–597. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
World Health Organization (WHO), . WHO
Classification of Head and Neck Tumors. 2023.
|
|
8
|
National Comprehensive Cancer Network
(NCCN), . NCCN Clinical Practice Guidelines in Oncology: Head and
Neck Cancers. 2025.
|
|
9
|
Liu FL, Zhang ZC, Zhou SL, Liu XL and Xu
W: Unlocking the therapeutic potential of LncRNA BLACAT1 in
hypopharynx squamous cell carcinoma. Discov Med. 36:546–558. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Liu Z, Zhao Z, Xie L, Xiao Z, Li M, Li Y
and Luo T: Proteomic analysis reveals chromatin remodeling as a
potential therapeutical target in neuroblastoma. J Transl Med.
23:2342025. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Elmusrati A, Wang J and Wang CY: Tumor
microenvironment and immune evasion in head and neck squamous cell
carcinoma. Int J Oral Sci. 13:242021. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Bryne M, Jenssen N and Boysen M:
Histological grading in the deep invasive front of T1 and T2
glottic squamous cell carcinomas has high prognostic value. Virch
Arch. 427:277–281. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Brandwein-Gensler M, Smith RV, Wang B,
Penner C, Theilken A, Broughel D, Schiff B, Owen RP, Smith J, Sarta
C, et al: Validation of the histologic risk model in a new cohort
of patients with head and neck squamous cell carcinoma. Am J Surg
Pathol. 34:676–688. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Fountzilas G, Ciuleanu E, Bobos M,
Kalogera-Fountzila A, Eleftheraki AG, Karayannopoulou G,
Zaramboukas T, Nikolaou A, Markou K, Resiga L, et al: Induction
chemotherapy followed by concomitant radiotherapy and weekly
cisplatin versus the same concomitant chemoradiotherapy in patients
with nasopharyngeal carcinoma: A randomized phase II study
conducted by the hellenic cooperative oncology group (HeCOG) with
biomarker evaluation. Ann Oncol. 23:427–435. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Krikelis D, Bobos M, Karayannopoulou G,
Resiga L, Chrysafi S, Samantas E, Andreopoulos D, Vassiliou V,
Ciuleanu E and Fountzilas G: Expression profiling of 21
biomolecules in locally advanced nasopharyngeal carcinomas of
Caucasian patients. BMC Clin Pathol. 13:12013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Fountzilas G, Psyrri A, Giannoulatou E,
Tikas I, Manousou K, Rontogianni D, Ciuleanu E, Ciuleanu T, Resiga
L, Zaramboukas T, et al: Prevalent somatic BRCA1 mutations shape
clinically relevant genomic patterns of nasopharyngeal carcinoma in
Southeast Europe. Int J Cancer. 142:66–80. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hendry S, Salgado R, Gevaert T, Russell
PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV,
Gonzalez-Ericsson PI, et al: Assessing tumor-infiltrating
lymphocytes in solid tumors: A practical review for pathologists
and proposal for a standardized method from the international
immunooncology biomarkers working group: Part 1: Assessing the host
immune response, TILs in invasive breast carcinoma and ductal
carcinoma in situ, metastatic tumor deposits and areas for further
research. Adv Anat Pathol. 24:235–251. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zhang D, He W, Wu C, Tan Y, He Y, Xu B,
Chen L, Li Q and Jiang J: Scoring system for tumor-infiltrating
lymphocytes and its prognostic value for gastric cancer. Front
Immunol. 10:712019. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chernock RD: Morphologic features of
conventional squamous cell carcinoma of the oropharynx:
‘Keratinizing’ and ‘nonkeratinizing’ histologic types as the basis
for a consistent classification system. Head Neck Pathol. 6 (Suppl
1):S41–S47. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Amin MB, Edge SB, Greene FL, Byrd DR,
Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR,
Sullivan DC, et al: AJCC Cancer Staging Manual. 8th Edition.
Springer International Publishing; Cham, Switzerland: pp. 91–156.
2018
|
|
21
|
Pollheimer MJ, Kornprat P, Lindtner RA,
Harbaum L, Schlemmer A, Rehak P and Langner C: Tumor necrosis is a
new promising prognostic factor in colorectal cancer. Human Pathol.
41:1749–1757. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Kumar V, Abbas AK, Aster JC and Perkins
JA: Robbins basic pathology. 10th Edition. Elsevier; Amsterdam,
Netherlands: pp. 1932017
|
|
23
|
Almangush A, Mäkitie AA, Hagström J,
Haglund C, Kowalski LP, Nieminen P, Coletta RD, Salo T and Leivo I:
Cell-in-cell phenomenon associates with aggressive characteristics
and cancer-related mortality in early oral tongue cancer. BMC
Cancer. 20:8432020. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jiang Z, Chen Z, Xu Y, Li H, Li Y, Peng L,
Shan H, Liu X, Wu H, Wu L, et al: Low-frequency ultrasound
sensitive piezo1 channels regulate keloid-related characteristics
of fibroblasts. Adv Sci. 11:e23054892024. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Ueno H, Kanemitsu Y, Sekine S, Ishiguro M,
Ito E, Hashiguchi Y, Kondo F, Shimazaki H, Mochizuki S, Kajiwara Y,
et al: Desmoplastic pattern at the tumor front defines
poor-prognosis subtypes of colorectal cancer. Am J Surg Pathol.
41:1506–1512. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Salgado R, Denkert C, Demaria S, Sirtaine
N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL,
Penault-Llorca F, et al: The evaluation of tumor-infiltrating
lymphocytes (TILs) in breast cancer: Recommendations by an
international TILs working group 2014. Ann Oncol. 26:259–271. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hendry S, Salgado R, Gevaert T, Russell
PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV,
Gonzalez-Ericsson PI, et al: Assessing tumor-infiltrating
lymphocytes in solid tumors: A practical review for pathologists
and proposal for a standardized method from the international
immuno-oncology biomarkers working group: Part 2: TILs in melanoma,
gastrointestinal tract carcinomas, non-small cell lung carcinoma
and mesothelioma, endometrial and ovarian carcinomas, squamous cell
carcinoma of the head and neck, genitourinary carcinomas, and
primary brain tumors. Adv Anat Pathol. 24:311–335. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Koletsa T, Kotoula V, Koliou GA, Manousou
K, Chrisafi S, Zagouri F, Sotiropoulou M, Pentheroudakis G,
Papoudou-Bai A, Christodoulou C, et al: Prognostic impact of
stromal and intratumoral CD3, CD8 and FOXP3 in adjuvantly treated
breast cancer: Do they add information over stromal
tumor-infiltrating lymphocyte density? Cancer Immunol Immunother.
69:1549–1564. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Brandwein-Gensler M, Teixeira MS, Lewis
CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML and Wang BY:
Oral squamous cell carcinoma: Histologic risk assessment, but not
margin status, is strongly predictive of local disease-free and
overall survival. Am J Surg Pathol. 29:167–178. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Agilent Technologies Inc, . PD-L1 IHC 22C3
pharmDx Interpretation Manual-Head and Neck Squamous Cell Carcinoma
(HNSCC). Santa Clara; CA, USA: pp. 1–72. https://www.agilent.com/cs/library/usermanuals/public/29314_22c3_pharmDx_hnscc_interpretation_manual_us.pdfApril
2–2024
|
|
31
|
Seethala RR, Baras A, Baskovich BW,
Birdsong GG, Fitzgibbons PL, Khoury JD and Schneider F: Head and
Neck Biomarker Reporting Template. Version 2.0.0.0. College of
American Patologists. 1–6. 2021.
|
|
32
|
Almangush A, Mäkitie AA, Triantafyllou A,
de Bree R, Strojan P, Rinaldo A, Hernandez-Prera JC, Suárez C,
Kowalski LP, Ferlito A and Leivo I: Staging and grading of oral
squamous cell carcinoma: An update. Oral Oncol. 107:1047992020.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Schmitd LB, Scanlon CS and D'Silva NJ:
Perineural invasion in head and neck cancer. J Dental Res.
97:742–750. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sharma HD, Mahadesh J, Monalisa W,
Gopinathan PA, Laxmidevi BL and Sanjenbam N: Quantitative
assessment of tumor-associated tissue eosinophilia and nuclear
organizing region activity to validate the significance of the
pattern of invasion in oral squamous cell carcinoma: A
retrospective study. J Oral Maxillofac Pathol. 25:258–265. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Binmadi N, Alsharif M, Almazrooa S,
Aljohani S, Akeel S, Osailan S, Shahzad M, Elias W and Mair Y:
Perineural invasion is a significant prognostic factor in oral
squamous cell carcinoma: A systematic review and meta-analysis.
Diagnostics (Basel). 13:33392023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Huang Q, Huang Y, Chen C, Zhang Y, Zhou J,
Xie C, Lu M, Xiong Y, Fang D, Yang Y, et al: Prognostic impact of
lymphovascular and perineural invasion in squamous cell carcinoma
of the tongue. Sci Rep. 13:38282023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yuan Y: Spatial heterogeneity in the tumor
microenvironment. Cold Spring Harb Perspect Med. 6:a0265832016.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Galon J, Mlecnik B, Bindea G, Angell HK,
Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, et
al: Towards the introduction of the ‘Immunoscore’ in the
classification of malignant tumours. J Pathol. 232:199–209. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zhang XM, Song LJ, Shen J, Yue H, Han YQ,
Yang CL, Liu SY, Deng JW, Jiang Y, Fu GH, et al: Prognostic and
predictive values of immune infiltrate in patients with head and
neck squamous cell carcinoma. Hum Pathol. 82:104–112. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Almangush A, De Keukeleire S, Rottey S,
Ferdinande L, Vermassen T, Leivo I and Mäkitie AA:
Tumor-infiltrating lymphocytes in head and neck cancer: Ready for
prime time? Cancers (Basel). 14:15582022. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Balermpas P, Michel Y, Wagenblast J, Seitz
O, Weiss C, Rödel F, Rödel C and Fokas E: Tumour-infiltrating
lymphocytes predict response to definitive chemoradiotherapy in
head and neck cancer. Br J Cancer. 110:501–509. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chatzopoulos K, Kotoula V, Manoussou K,
Markou K, Vlachtsis K, Angouridakis N, Nikolaou A, Vassilakopoulou
M, Psyrri A and Fountzilas G: Tumor infiltrating lymphocytes and
CD8+ T cell subsets as prognostic markers in patients with
surgically treated laryngeal squamous cell carcinoma. Head Neck
Pathol. 14:689–700. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Yang WF, Wong MCM, Thomson PJ, Li KY and
Su YX: The prognostic role of PD-L1 expression for survival in head
and neck squamous cell carcinoma: A systematic review and
meta-analysis. Oral Oncol. 86:81–90. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Crosta S, Boldorini R, Bono F, Brambilla
V, Dainese E, Fusco N, Gianatti A, L'Imperio V, Morbini P and Pagni
F: PD-L1 testing and squamous cell carcinoma of the head and neck:
A multicenter study on the diagnostic reproducibility of different
protocols. Cancers (Basel). 13:2922021. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
De Keukeleire SJ, Vermassen T, Deron P,
Huvenne W, Duprez F, Creytens D, Van Dorpe J, Ferdinande L and
Rottey S: Concordance, correlation, and clinical impact of
standardized PD-L1 and TIL scoring in SCCHN. Cancers (Basel).
14:24312022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
He B, Wang L, Zhou W, Liu H, Wang Y, Lv K
and He K: A fusion model to predict the survival of colorectal
cancer based on histopathological image and gene mutation. Sci Rep.
15:96772025. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Baxi V, Edwards R, Montalto M and Saha S:
Digital pathology and artificial intelligence in translational
medicine and clinical practice. Mod Pathol. 35:23–32. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Lee LY, Yang CH, Lin YC, Hsieh YH, Chen
YA, Chang MD, Lin YY and Liao CT: A domain knowledge enhanced yield
based deep learning classifier identifies perineural invasion in
oral cavity squamous cell carcinoma. Front Oncol. 12:9515602022.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Abousamra S, Gupta R, Hou L, Batiste R,
Zhao T, Shankar A, Rao A, Chen C, Samaras D, Kurc T and Saltz J:
Deep learning-based mapping of tumor infiltrating lymphocytes in
whole slide images of 23 types of cancer. Front Oncol.
11:8066032021. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Badve S, Kumar GL, Lang T, Peigin E, Pratt
J, Anders R, Chatterjee D, Gonzalez RS, Graham RP, Krasinskas AM,
et al: Augmented reality microscopy to bridge trust between AI and
pathologists. NPJ Precis Oncol. 9:1392025. View Article : Google Scholar : PubMed/NCBI
|
