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Review

Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)

  • Authors:
    • Buyun Jia
    • Hui Cheng
    • Peizheng Yang
    • Xiangyu Wang
    • Shanshan Li
    • Jinghui Wang
  • View Affiliations / Copyright

    Affiliations: School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui 230012, P.R. China, Key Laboratory of Xi'an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei, Anhui 230012, P.R. China
  • Article Number: 583
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    Published online on: October 10, 2025
       https://doi.org/10.3892/ol.2025.15329
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Abstract

Long non‑coding (lnc)RNAs are notable participants in gene regulation, and maternally expressed gene 3 (MEG3) has been implicated in the development and progression of several types of cancer, underscoring its potential as a key player in oncogenesis. The present review aimed to explore the functional role of MEG3 in gastric cancer (GC) and elucidate the underlying molecular mechanisms, as well as to summarize the expression changes of MEG3 in GC, its influence on tumor cell biological behaviors and the potential signaling pathways involved. Ultimately, the present synthesis of current knowledge seeks to provide novel insights for the diagnosis and treatment of GC, highlighting MEG3 as a promising target for future therapeutic strategies.
View Figures

Figure 1

Relationship between MEG3 and the p53
signaling pathway. MEG3, maternally expressed gene 3; p53, protein
53; lncRNA, long non-coding RNA; GSK-3β, glycogen synthase
kinase-3; Akt, protein kinase B; PTEN, phosphatase and tensin
homologue deleted on chromosome ten; Ctnn-β, catenin beta; Caspase,
cysteinyl aspartate specific proteinase; Bcl-2, B-cell lymphoma-2;
Bax, Bcl-2 associated X; TSP1,thrombin sensitive protein 1; BAI1,
brain-specific angiogenesis inhibitor 1.

Figure 2

Impact of MEG3 on the tumor
microenvironment. MEG3, maternally expressed gene 3; lncRNA, long
non-coding RNA; miR, microRNA; DAB2, disabled homolog 2; HS2ST1,
heparan sulfate-2-O-sulfotransferase 1; VEGF, vascular endothelial
growth factor; M1, classically activated macrophage; M2,
alternatively activated macrophage.
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Copy and paste a formatted citation
Spandidos Publications style
Jia B, Cheng H, Yang P, Wang X, Li S and Wang J: Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review). Oncol Lett 30: 583, 2025.
APA
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., & Wang, J. (2025). Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review). Oncology Letters, 30, 583. https://doi.org/10.3892/ol.2025.15329
MLA
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., Wang, J."Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)". Oncology Letters 30.6 (2025): 583.
Chicago
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., Wang, J."Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)". Oncology Letters 30, no. 6 (2025): 583. https://doi.org/10.3892/ol.2025.15329
Copy and paste a formatted citation
x
Spandidos Publications style
Jia B, Cheng H, Yang P, Wang X, Li S and Wang J: Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review). Oncol Lett 30: 583, 2025.
APA
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., & Wang, J. (2025). Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review). Oncology Letters, 30, 583. https://doi.org/10.3892/ol.2025.15329
MLA
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., Wang, J."Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)". Oncology Letters 30.6 (2025): 583.
Chicago
Jia, B., Cheng, H., Yang, P., Wang, X., Li, S., Wang, J."Role and mechanistic study of long non‑coding RNA maternally expressed gene 3 in gastric cancer (Review)". Oncology Letters 30, no. 6 (2025): 583. https://doi.org/10.3892/ol.2025.15329
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