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Article Open Access

Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors

  • Authors:
    • Bin Xu
    • Donghui Lu
    • Dongmei Wang
    • Huan Ma
    • Zhijie Li
    • Lijie Zhang
    • Meiqin Liu
    • Donglai Lv
  • View Affiliations / Copyright

    Affiliations: People's Liberation Army Clinical College, Anhui Medical University, Hefei, Anhui 230031, P.R. China, Department of Medical Oncology, 901st Hospital of The Joint Logistics Support Force of The People's Liberation Army, Hefei, Anhui 230031, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 601
    |
    Published online on: October 17, 2025
       https://doi.org/10.3892/ol.2025.15347
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Abstract

Non‑small cell lung carcinoma (NSCLC) accounts for most cancer‑related deaths. Whilst epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) are effective in prolonging the survival of patients with EGFR mutations, resistance to these therapies inevitably emerges. The present study aimed to analyze the efficacy and safety of combining Gamma Knife therapy and first‑generation EGFR‑TKIs treatment in patients with advanced EGFR‑mutant NSCLC. The present study was a retrospective analysis performed at a single center. The patients included in the analysis were histologically confirmed as inoperable stage III or IV lung adenocarcinoma with EGFR‑sensitive mutations (19DEL or 21L858R). Patients received first‑generation EGFR‑TKIs treatment, including gefitinib, erlotinib and icotinib, then received Gamma Knife consolidation therapy for the treatment of residual lesions in the chest, with a total of 10‑17 sessions administered five times a week. Each session delivered a fractionated dose between 3.0‑5.5 Gy. The primary endpoint was progression‑free survival (PFS) and overall survival (OS), and the secondary endpoints were objective response rate (ORR) and safety. Between October 2014 and November 2021, the 35 patients included in the follow‑up analysis received Gamma Knife therapy combined with EGFR‑TKIs treatment, with a follow‑up visit in December 2023. The PFS and median OS were 20 (range, 17.6‑22.4) and 39 (range, 32.0‑46.0) months, respectively. The ORR was 77% and the incidence of grade III or higher radiation pneumonitis was 3%. Univariate analysis indicated an improved survival trend for patients with the following characteristics: Aged ≥62 years, carcinoembryonic antigen (CEA) level of <10 ng/ml and those with grade I or no radiation pneumonia; however, the differences were not statistically significant. Multivariate analysis demonstrated that non‑smoking patients, those with a CEA level of <10 ng/ml, grade I or no radiation pneumonitis after treatment and those treated with icotinib had a statistically longer PFS. In conclusion, combining first‑generation EGFR‑TKIs with Gamma Knife therapy can delay EGFR resistance, extend PFS and OS, and result in a low incidence of toxic and side effects. However, further prospective randomized controlled studies are required to validate the results of the present study.
View Figures

Figure 1

Treatment plan for patients during
the complete observation period.

Figure 2

Kaplan-Meier curve for PFS. PFS,
progression-free survival; CI, confidence interval.

Figure 3

Kaplan-Meier curve for mOS. mOS,
median overall survival; CI, confidence interval.
View References

1 

Thai AA, Solomon BJ, Sequist LV, Gainor JF and Heist RS: Lung cancer. Lancet. 398:535–554. 2021. View Article : Google Scholar

2 

Cancer Genome Atlas Research Network, . Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, et al: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 362:2380–2388. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, et al: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13:239–246. 2012. View Article : Google Scholar

5 

Shen YW, Zhang XM, Li ST, Lv M and Yang J, Wang F, Chen ZL, Wang BY, Li P, Chen L and Yang J: Efficacy and safety of icotinib as first-line therapy in patients with advanced non-small-cell lung cancer. Onco Targets Ther. 9:929–935. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Wu YL, Zhou C, Cheng Y, Lu S, Chen GY, Huang C, Huang YS, Yan HH, Ren S, Liu Y and Yang JJ: Erlotinib as second-line treatment in patients with advanced non-small-cell lung cancer and asymptomatic brain metastases: A phase II study (CTONG-0803). Ann Oncol. 24:993–999. 2013. View Article : Google Scholar

7 

Iuchi T, Shingyoji M, Sakaida T, Hatano K, Nagano O, Itakura M, Kageyama H, Yokoi S, Hasegawa Y, Kawasaki K and Iizasa T: Phase II trial of gefitinib alone without radiation therapy for Japanese patients with brain metastases from EGFR-mutant lung adenocarcinoma. Lung Cancer. 82:282–287. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Roper N, Brown AL, Wei JS, Pack S, Trindade C, Kim C, Restifo O, Gao S, Sindiri S, Mehrabadi F, et al: Clonal evolution and heterogeneity of osimertinib acquired resistance mechanisms in EGFR mutant lung cancer. Cell Rep Med. 1:1000072020. View Article : Google Scholar : PubMed/NCBI

9 

Park K, Yu CJ, Kim SW, Lin MC, Sriuranpong V, Tsai CM, Lee JS, Kang JH, Chan KC, Perez-Moreno P, et al: First-line erlotinib therapy until and beyond response evaluation criteria in solid tumors progression in asian patients with epidermal growth factor receptor Mutation-positive Non-Small-Cell lung cancer: The ASPIRATION study. JAMA Oncol. 2:305–312. 2016. View Article : Google Scholar

10 

Chaft JE, Oxnard GR, Sima CS, Kris MG, Miller VA and Riely GJ: Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: Implications for clinical trial design. Clin Cancer Res. 17:6298–6303. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Heitmann J and Guckenberger M: Perspectives on oligometastasis: Challenges and opportunities. J Thorac Dis. 10:113–117. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Hu F, Xu J, Zhang B, Li C, Nie W, Gu P, Hu P, Wang H, Zhang Y, Shen Y, et al: Efficacy of local consolidative therapy for oligometastatic lung adenocarcinoma patients harboring epidermal growth factor receptor mutations. Clin Lung Cancer. 20:e81–e90. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Seong H, Kim SH, Kim MH, Kim J and Eom JS: Additional local therapy before disease progression for EGFR-mutated advanced lung cancer: A systematic review and meta-analysis. Transl Lung Cancer Res. 13:491–502. 2024. View Article : Google Scholar : PubMed/NCBI

14 

Xia T, Li H, Sun Q, Wang Y, Fan N, Yu Y, Li P and Chang JY: Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 66:117–125. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zhang LP, Nie Q, Kang JB, Wang B, Cai CL, Li JG and Qi WJ: Efficacy of whole body gamma-knife radiotherapy combined with thermochemotherapy on locally advanced pancreatic cancer. Chin J Cancer. 27:1204–1207. 2008.(In Chinese).

16 

Yu W, Tang L, Lin F, Li D, Wang J, Yang Y and Shen Z: Stereotactic radiosurgery, a potential alternative treatment for pulmonary metastases from osteosarcoma. Int J Oncol. 44:1091–1098. 2014. View Article : Google Scholar

17 

Liu K, Zheng D, Xu G, Du Z and Wu S: Local thoracic therapy improve prognosis for stage IV non-small cell lung cancer patients combined with chemotherapy: A Surveillance, Epidemiology, and End Results database analysis. PLoS One. 12:e01873502017. View Article : Google Scholar : PubMed/NCBI

18 

Gomez DR, Tang C, Zhang J, Blumenschein GR Jr, Hernandez M, Lee JJ, Ye R, Palma DA, Louie AV, Camidge DR, et al: Local consolidative therapy vs. maintenance therapy or observation for patients with oligometastatic Non-Small-Cell lung cancer: Long-Term results of a Multi-Institutional, Phase II, randomized study. J Clin Oncol. 37:1558–1565. 2019. View Article : Google Scholar

19 

Palma DA, Olson R, Harrow S, Gaede S, Louie AV, Haasbeek C, Mulroy L, Lock M, Rodrigues GB, Yaremko BP, et al: Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: Long-term results of the SABR-COMET phase II randomized trial. J Clin Oncol. 38:2830–2838. 2020. View Article : Google Scholar

20 

Wang XS, Bai YF, Verma V, Yu RL, Tian W, Ao R, Deng Y, Zhu XQ, Liu H, Pan HX, et al: Randomized trial of First-line tyrosine kinase inhibitor with or without radiotherapy for synchronous oligometastatic EGFR-Mutated Non-Small cell lung cancer. J Natl Cancer Inst. 115:742–748. 2023. View Article : Google Scholar

21 

Kuo SW, Chen PH, Lu TP, Chen KC, Liao HC, Tsou KC, Tsai TM, Lin MW, Hsu HH and Chen JS: Primary tumor resection for Stage IV Non-small-cell lung cancer without progression After First-Line epidermal growth factor receptor-tyrosine kinase inhibitor treatment: A retrospective Case-Control study. Ann Surg Oncol. 29:4873–4884. 2022. View Article : Google Scholar

22 

Hsu KH, Huang JW, Tseng JS, Chen KW, Weng YC, Yu SL, Yang TY, Huang YH, Chen JJW, Chen KC, et al: Primary tumor radiotherapy during EGFR-TKI disease control improves survival of treatment naïve advanced EGFR-Mutant lung adenocarcinoma patients. Onco Targets Ther. 14:2139–2148. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Peng P, Gong J, Zhang Y, Zhou S, Li Y, Han G, Meng R, Chen Y, Yang M, Shen Q, et al: EGFR-TKIs plus stereotactic body radiation therapy (SBRT) for stage IV Non-small cell lung cancer (NSCLC): A prospective, multicenter, randomized, controlled phase II study. Radiother Oncol. 184:1096812023. View Article : Google Scholar

24 

Xu Q, Zhou F, Liu H, Jiang T, Li X, Xu Y and Zhou C: Consolidative local ablative therapy improves the survival of patients with synchronous oligometastatic NSCLC harboring EGFR Activating mutation treated with first-line EGFR-TKIs. J Thorac Oncol. 13:1383–1392. 2018. View Article : Google Scholar

25 

Wang Y, Li Y, Xia L, Niu K, Chen X, Lu D, Kong R, Chen Z and Sun J: Continued EGFR-TKI with concurrent radiotherapy to improve time to progression (TTP) in patients with locally progressive non-small cell lung cancer (NSCLC) after front-line EGFR-TKI treatment. Clin Transl Oncol. 20:366–373. 2018. View Article : Google Scholar

26 

Chiou GY, Chiang CL, Yang HC, Shen CI, Wu HM, Chen YW, Chen CJ, Luo YH, Hu YS, Lin CJ, et al: Combined stereotactic radiosurgery and tyrosine kinase inhibitor therapy versus tyrosine kinase inhibitor therapy alone for the treatment of non-small cell lung cancer patients with brain metastases. J Neurosurg. 137:563–570. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Wu JJ, Tseng JS, Zheng ZR, Chu CH, Chen KC, Lin MW, Huang YH, Hsu KH, Yang TY, Yu SL, et al: Primary tumor consolidative therapy improves the outcomes of patients with advanced EGFR-mutant lung adenocarcinoma treated with first-line osimertinib. Ther Adv Med Oncol. 16:175883592312206062024. View Article : Google Scholar

28 

Guo T, Ni J, Yang X, Li Y, Li Y, Zou L, Wang S, Liu Q, Chu L, Chu X, et al: Pattern of Recurrence analysis in metastatic EGFR-Mutant NSCLC treated with osimertinib: Implications for consolidative stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 107:62–71. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Ando M, Ando Y, Hasegawa Y, Shimokata K, Minami H, Wakai K, Ohno Y and Sakai S: Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer. Br J Cancer. 85:1634–1639. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, D'Amico TA, et al: NCCN guidelines insights: Non-Small cell lung cancer, version 2022. J Natl Compr Canc Netw. 20:497–530. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhang S, Wang J, Zhou S, Ren S, et al: Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12:735–742. 2011. View Article : Google Scholar

33 

Ju X, Li M, Zhou Z, Zhang K, Han W, Fu G, Cao Y and Wang L: 4D-CT-based plan target volume (PTV) definition compared with conventional PTV definition using general margin in radiotherapy for lung cancer. Zhonghua Zhong Liu Za Zhi. 36:34–38. 2014.(In Chinese).

34 

Cox JD, Stetz J and Pajak TF: Toxicity criteria of the radiation therapy oncology group (RTOG) and the european organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1341–1346. 1995. View Article : Google Scholar : PubMed/NCBI

35 

Zhang S, Sun Q, Cai F, Li H and Zhou Y: Local therapy treatment conditions for oligometastatic non-small cell lung cancer. Front Oncol. 12:10281322022. View Article : Google Scholar

36 

Iyengar P, Wardak Z, Gerber DE, Tumati V, Ahn C, Hughes RS, Dowell JE, Cheedella N, Nedzi L, Westover KD, et al: Consolidative radiotherapy for limited metastatic Non-Small-Cell lung cancer: A Phase 2 randomized clinical trial. JAMA Oncol. 4:e1735012018. View Article : Google Scholar

37 

Ohtaki Y, Shimizu K, Suzuki H, Suzuki K, Tsuboi M, Mitsudomi T, Takao M, Murakawa T, Ito H, Yoshimura K, et al: Salvage surgery for non-small cell lung cancer after tyrosine kinase inhibitor treatment. Lung Cancer. 153:108–116. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Tseng JS, Hsu KH, Zheng ZR, Yang TY, Chen KC, Huang YH, Su KY, Yu SL and Chang GC: Primary tumor resection is associated with a better outcome among advanced EGFR-Mutant lung adenocarcinoma patients receiving EGFR-TKI treatment. Oncology. 99:32–40. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Takenaka M, Tanaka F, Kajiyama K, Manabe T, Yoshimatsu K, Mori M, Kanayama M, Taira A, Kuwata T, Nawata A and Kuroda K: Outcomes and pathologic response of primary lung cancer treated with tyrosine kinase inhibitor/immune checkpoint inhibitor before salvage surgery. Surg Today. 54:1146–1153. 2024. View Article : Google Scholar : PubMed/NCBI

40 

Elamin YY, Gomez DR, Antonoff MB, Robichaux JP, Tran H, Shorter MK, Bohac JM, Negrao MV, Le X, Rinsurogkawong W, et al: Local consolidation therapy (LCT) after first line tyrosine kinase inhibitor (TKI) for patients with EGFR mutant metastatic Non-small-cell lung cancer (NSCLC). Clin Lung Cancer. 20:43–47. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Deng R, Liu J, Song T, Xu T, Li Y, Duo L, Xiang L, Yu X, Lei J and Cao F: Primary lesion radiotherapy during first-line icotinib treatment in EGFR-mutated NSCLC patients with multiple metastases and no brain metastases: A single-center retrospective study. Strahlenther Onkol. 198:1082–1093. 2022. View Article : Google Scholar

42 

Chang SJ and Bristow RE: Evolution of surgical treatment paradigms for advanced-stage ovarian cancer: Redefining ‘optimal’ residual disease. Gynecol Oncol. 125:483–492. 2012. View Article : Google Scholar

43 

Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A and Colombo PE: Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial. Int J Gynecol Cancer. 30:888–892. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Lin MW, Yu SL, Hsu YC, Chen YM, Lee YH, Hsiao YJ, Lin JW, Su TJ, Jeffrey Yang CF, Chiang XH, et al: Salvage surgery for advanced lung adenocarcinoma after epidermal growth factor receptor tyrosine kinase inhibitor treatment. Ann Thorac Surg. 116:111–119. 2023. View Article : Google Scholar : PubMed/NCBI

45 

Al-Halabi H, Sayegh K, Digamurthy SR, Niemierko A, Piotrowska Z, Willers H and Sequist LV: Pattern of failure analysis in metastatic EGFR-Mutant lung cancer treated with tyrosine kinase inhibitors to identify candidates for consolidation stereotactic body radiation therapy. J Thorac Oncol. 10:1601–1607. 2015. View Article : Google Scholar

46 

Wee P and Wang Z: Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel). 9:522017. View Article : Google Scholar : PubMed/NCBI

47 

Byrne NM, Tambe P and Coulter JA: Radiation response in the tumour microenvironment: Predictive biomarkers and future perspectives. J Pers Med. 11:532021. View Article : Google Scholar : PubMed/NCBI

48 

Won YW, Han JY, Lee GK, Park SY, Lim KY, Yoon KA, Yun T, Kim HT and Lee JS: Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations. J Clin Pathol. 64:947–952. 2011. View Article : Google Scholar

49 

Hong W, Wu Q, Zhang J and Zhou Y: Prognostic value of EGFR 19-del and 21-L858R mutations in patients with non-small cell lung cancer. Oncol Lett. 18:3887–3895. 2019.

50 

Chen Y, Wang S, Zhang B, Zhao Y, Zhang L, Hu M, Zhang W and Han B: Clinical factors affecting the response to osimertinib in Non-Small cell lung cancer patients with an acquired epidermal growth factor receptor T790M mutation: A Long-Term survival analysis. Target Oncol. 15:337–345. 2020. View Article : Google Scholar

51 

Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, Dechaphunkul A, Imamura F, Nogami N, Kurata T, et al: Osimertinib in untreated EGFR-Mutated advanced Non-Small-Cell Lung cancer. N Engl J Med. 378:113–125. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Ramalingam SS, Vansteenkiste J, Planchard D, Cho BC, Gray JE, Ohe Y, Zhou C, Reungwetwattana T, Cheng Y, Chewaskulyong B, et al: Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC. N Engl J Med. 382:41–50. 2020. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Xu B, Lu D, Wang D, Ma H, Li Z, Zhang L, Liu M and Lv D: Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors. Oncol Lett 30: 601, 2025.
APA
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L. ... Lv, D. (2025). Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors. Oncology Letters, 30, 601. https://doi.org/10.3892/ol.2025.15347
MLA
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L., Liu, M., Lv, D."Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors". Oncology Letters 30.6 (2025): 601.
Chicago
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L., Liu, M., Lv, D."Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors". Oncology Letters 30, no. 6 (2025): 601. https://doi.org/10.3892/ol.2025.15347
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Spandidos Publications style
Xu B, Lu D, Wang D, Ma H, Li Z, Zhang L, Liu M and Lv D: Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors. Oncol Lett 30: 601, 2025.
APA
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L. ... Lv, D. (2025). Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors. Oncology Letters, 30, 601. https://doi.org/10.3892/ol.2025.15347
MLA
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L., Liu, M., Lv, D."Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors". Oncology Letters 30.6 (2025): 601.
Chicago
Xu, B., Lu, D., Wang, D., Ma, H., Li, Z., Zhang, L., Liu, M., Lv, D."Gamma Knife consolidation therapy improves prognosis in patients with advanced epidermal growth factor receptor‑mutant lung adenocarcinoma treated with first‑generation epidermal growth factor receptor‑tyrosine kinase inhibitors". Oncology Letters 30, no. 6 (2025): 601. https://doi.org/10.3892/ol.2025.15347
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