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Article Open Access

Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma

  • Authors:
    • Xiaobo Zhang
    • Guang Li
    • Feng Liu
    • Rui Shi
    • Jing Wen
    • Wen Wu
    • Jinqian Dai
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Xi'an Central Hospital/Xi'an Institute of Hematology, Xi'an, Shaanxi 710000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 603
    |
    Published online on: October 21, 2025
       https://doi.org/10.3892/ol.2025.15349
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Abstract

Non‑Hodgkin lymphoma (NHL), a heterogeneous malignancy accounting for ~90% of lymphomas, often requires chemotherapy as the primary treatment for patients unsuitable for stem cell transplantation. This study aimed to analyze the therapeutic effects of gemcitabine combined with oxaliplatin on NHL and examine the prognostic factors affecting patients with NHL. A total of 106 patients with NHL were retrospectively selected and divided into a control group (CG; n=50 received oxaliplatin treatment) and an observation group (OG; n=56 received oxaliplatin combined with gemcitabine treatment) based on the differences in treatment measures. Clinical data, therapeutic efficacy, adverse reactions, improvement in B symptoms, post‑treatment levels of lactate dehydrogenase (LDH) and TGF‑β1 and post‑treatment Karnofsky Performance Status (KPS) scores were collected from patients in both groups. Prognostic factors for NHL were analyzed based on the results of a 2‑year follow‑up. In the OG, the complete remission rate (CRR) was 73.21% and the disease control rate (DCR) was 91.07%, whereas in the CG, the CRR was 52.00% and the DCR was 80.00%, demonstrating a significant intergroup difference (P<0.05). The OG had an overall survival (OS) of 13.6 months and a progression‑free survival (PFS) of 8.9 months, and the CG had an OS of 11.3 months and a PFS of 6.1 months. After chemotherapy, the serum LDH and TGF‑β1 levels in the OG were significantly lower compared with those in the CG, and the KPS scores were higher compared with those in the CG (all P<0.05). Multivariate logistic regression analysis indicated that the Ann Arbor stage and the International Prognostic Index score for lymphoma were independent prognostic risk factors for patients with NHL (both P<0.05). The combination therapy of gemcitabine and oxaliplatin was demonstrated to be safe for patients with NHL. This combination treatment demonstrated notable overall efficacy and improved functional improvement compared with oxaliplatin monotherapy.
View Figures

Figure 1

Comparison of survival time between
the two groups. The OG had (A) an OS of 13.6 months and (B) a PFS
of 8.9 months. The CG had (A) an OS of 11.3 months and (B) a PFS of
6.1 months. OG, observation group; CG, control group; OS, overall
survival; PFS, progression-free survival.

Figure 2

Comparison of incidence of toxic side
effects between the two groups. There were no statistically
significant differences between the groups in terms of (A)
leukopenia-related toxic side effects, (B) gastrointestinal
reactions and (C) liver and kidney damage (all P>0.05). OG,
observation group; CG, control group.

Figure 3

Comparison of LDH and TGF-β1 levels
between the two groups before and after chemotherapy. Before
chemotherapy, there was no significant difference in serum (A) LDH
and (B) TGF-β1 levels between the two groups (both P>0.05). Upon
discharge after chemotherapy, patients in the OG demonstrated
significantly lower serum (A) LDH and (B) TGF-β1 levels compared
with that of CG. *P<0.05. OG, observation group; CG, control
group; LDH, lactate dehydrogenase.

Figure 4

Comparison of KPS scores between the
two groups before and after treatment. (A) Before treatment, there
was no statistically significant difference in KPS scores between
the two groups (P>0.05). (B) After treatment, KPS scores in the
OG were higher compared with those in the CG (P<0.05).
*P<0.05. OG, observation group; CG, control group; KPS,
Karnofsky Performance Status.

Figure 5

Analysis of prognostic factors in
patients with non-Hodgkin lymphoma. Multivariate logistic
regression analysis indicated that the Ann Arbor stage and the IPI
score for lymphoma were independent prognostic risk factors for
patients with non-Hodgkin lymphoma. IPI, International Prognostic
Index.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Li G, Liu F, Shi R, Wen J, Wu W and Dai J: Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma. Oncol Lett 30: 603, 2025.
APA
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., & Dai, J. (2025). Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma. Oncology Letters, 30, 603. https://doi.org/10.3892/ol.2025.15349
MLA
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., Dai, J."Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma". Oncology Letters 30.6 (2025): 603.
Chicago
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., Dai, J."Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma". Oncology Letters 30, no. 6 (2025): 603. https://doi.org/10.3892/ol.2025.15349
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Li G, Liu F, Shi R, Wen J, Wu W and Dai J: Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma. Oncol Lett 30: 603, 2025.
APA
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., & Dai, J. (2025). Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma. Oncology Letters, 30, 603. https://doi.org/10.3892/ol.2025.15349
MLA
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., Dai, J."Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma". Oncology Letters 30.6 (2025): 603.
Chicago
Zhang, X., Li, G., Liu, F., Shi, R., Wen, J., Wu, W., Dai, J."Analysis of the efficacy and prognostic factors of gemcitabine combined with oxaliplatin in non‑Hodgkin lymphoma". Oncology Letters 30, no. 6 (2025): 603. https://doi.org/10.3892/ol.2025.15349
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