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Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases

  • Authors:
    • Meng-Xue Ma
    • Ya-Li Zhang
    • Li-Na Xing
    • Qiu-Yi Wang
    • Shukai Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Haematology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of General Medical, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 253
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    Published online on: April 20, 2026
       https://doi.org/10.3892/ol.2026.15607
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Abstract

Peripheral T‑cell lymphoma, not otherwise specified (PTCL‑NOS) is the most common histological subtype of PTCL. PTCL‑NOS has a relatively low incidence, and its pathogenesis and mechanisms of drug resistance remain unclear, leading to lagging research progress. The aim of the present study was to summarize the clinical features and outcomes of patients with PTCL‑NOS. A total of 30 patients with treatment‑naive PTCL‑NOS who were admitted to The Second Hospital of Hebei Medical University (Shijiazhuang, China) between September 2013 and September 2023 were retrospectively analysed. The median age at diagnosis was 59 years (range, 17‑70 years), and the male‑to‑female ratio was 2.75:1. The median follow‑up duration was 59 months. The 3‑year overall survival (OS) and progression‑free survival (PFS) rates were 50.4 and 28.9%, respectively. Multivariate analysis showed that an Eastern Cooperative Oncology Group performance status >1, bone marrow involvement and a platelet count <150x109/l were independent risk factors for OS, whereas bone marrow involvement and albumin levels <35 g/l were independent risk factors for PFS. There was no significant difference between the cyclophosphamide, doxorubicin, vincristine, prednisone and etoposide regimen and the cyclophosphamide, vincristine, doxorubicin and prednisone regimen, whereas combinations with chidamide showed a trend toward an improved PFS. Within the cohort, 2 patients with relapsed and refractory CD30‑positive PTCL‑NOS received salvage chemotherapy with brentuximab vedotin (BV), a monoclonal antibody, and achieved complete metabolic remission, followed by sequential allogeneic haematopoietic stem‑cell transplantation, resulting in long‑term sustained remission. In conclusion, patients diagnosed with PTCL‑NOS generally have a poor prognosis. Nevertheless, the use of innovative targeted therapies, such as chidamide and BV, shows potential to improve treatment outcomes in these patients.
View Figures

Figure 1

OS and PFS curves of 30 patients with
peripheral T-cell lymphoma, not otherwise specified. OS, overall
survival; PFS, progression-free survival.

Figure 2

OS and PFS curves of 21 patients with
relapsed/refractory peripheral T-cell lymphoma, not otherwise
specified. OS, overall survival; PFS, progression-free
survival.

Figure 3

(A) OS and (B) PFS curves of
relapsed/refractory patients in the salvage therapy group and the
non-salvage therapy group. OS, overall survival; PFS,
progression-free survival.

Figure 4

(A) OS and (B) PFS curves of patients
in the CHOP and CHOPE regimen groups. CHOP, cyclophosphamide,
vincristine, doxorubicin and prednisone; CHOPE, cyclophosphamide,
doxorubicin, vincristine, prednisone and etoposide; OS, overall
survival; PFS, progression-free survival.

Figure 5

(A) OS and (B) PFS curves of patients
in the chidamide treatment group and the non-chidamide treatment
group. OS, overall survival; PFS, progression-free survival.
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Copy and paste a formatted citation
Spandidos Publications style
Ma M, Zhang Y, Xing L, Wang Q and Qiao S: Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases. Oncol Lett 31: 253, 2026.
APA
Ma, M., Zhang, Y., Xing, L., Wang, Q., & Qiao, S. (2026). Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases. Oncology Letters, 31, 253. https://doi.org/10.3892/ol.2026.15607
MLA
Ma, M., Zhang, Y., Xing, L., Wang, Q., Qiao, S."Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases". Oncology Letters 31.6 (2026): 253.
Chicago
Ma, M., Zhang, Y., Xing, L., Wang, Q., Qiao, S."Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases". Oncology Letters 31, no. 6 (2026): 253. https://doi.org/10.3892/ol.2026.15607
Copy and paste a formatted citation
x
Spandidos Publications style
Ma M, Zhang Y, Xing L, Wang Q and Qiao S: Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases. Oncol Lett 31: 253, 2026.
APA
Ma, M., Zhang, Y., Xing, L., Wang, Q., & Qiao, S. (2026). Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases. Oncology Letters, 31, 253. https://doi.org/10.3892/ol.2026.15607
MLA
Ma, M., Zhang, Y., Xing, L., Wang, Q., Qiao, S."Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases". Oncology Letters 31.6 (2026): 253.
Chicago
Ma, M., Zhang, Y., Xing, L., Wang, Q., Qiao, S."Clinical features and outcomes of peripheral T‑cell lymphoma, not otherwise specified: A single institution retrospective analysis of 30 cases". Oncology Letters 31, no. 6 (2026): 253. https://doi.org/10.3892/ol.2026.15607
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