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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2003 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas

  • Authors:
    • Masayoshi Nishimine
    • Mitsutoshi Nakamura
    • Munehiro Kishi
    • Masumi Okamoto
    • Keiji Shimada
    • Eiwa Ishida
    • Tadaaki Kirita
    • Noboru Konishi

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan
  • Pages: 555-560
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/or.10.3.555
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Abstract

The p14ARF and p16INK4a genes are localized to 9p21, where genetic alterations have been reported to be frequent in various human neoplasms. To elucidate their status in salivary gland tumorigenesis, we analyzed a series of 36 salivary gland carcinomas (SGCs) using methylation-specific PCR, differential PCR and immunohistochemistry. Homozygous deletion (3 cases) or methylation (7 cases) of p14ARF was detected in 10 (28%) SGCs, one and three showing co-deletion and co-methylation of both p14ARF and p16INK4a genes, respectively. A total of 5 (14%) SGCs demonstrated homozygous deletion (1 case) or methylation (4 cases) of p16INK4a, all but one being adenoid cystic carcinomas. Immunohistochemical study revealed loss of p14ARF and p16INK4a expression in 11 samples (31%), correlating with the gene status. These results indicate that inactivation of p14ARF and p16INK4a genes by either homozygous deletion or promoter hypermethylation may be important for the molecular pathogenesis of salivary malignant tumors, and provide clear evidence that epigenetic changes like methylation are related to salivary gland carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Nishimine M, Nakamura M, Kishi M, Okamoto M, Shimada K, Ishida E, Kirita T and Konishi N: Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas. Oncol Rep 10: 555-560, 2003.
APA
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E. ... Konishi, N. (2003). Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas. Oncology Reports, 10, 555-560. https://doi.org/10.3892/or.10.3.555
MLA
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E., Kirita, T., Konishi, N."Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas". Oncology Reports 10.3 (2003): 555-560.
Chicago
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E., Kirita, T., Konishi, N."Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas". Oncology Reports 10, no. 3 (2003): 555-560. https://doi.org/10.3892/or.10.3.555
Copy and paste a formatted citation
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Spandidos Publications style
Nishimine M, Nakamura M, Kishi M, Okamoto M, Shimada K, Ishida E, Kirita T and Konishi N: Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas. Oncol Rep 10: 555-560, 2003.
APA
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E. ... Konishi, N. (2003). Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas. Oncology Reports, 10, 555-560. https://doi.org/10.3892/or.10.3.555
MLA
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E., Kirita, T., Konishi, N."Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas". Oncology Reports 10.3 (2003): 555-560.
Chicago
Nishimine, M., Nakamura, M., Kishi, M., Okamoto, M., Shimada, K., Ishida, E., Kirita, T., Konishi, N."Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas". Oncology Reports 10, no. 3 (2003): 555-560. https://doi.org/10.3892/or.10.3.555
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