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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2007 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG

  • Authors:
    • Ken Shirato
    • Kazuhiko Imaizumi
    • Akihisa Abe
    • Akio Tomoda

  • View Affiliations / Copyright

    Affiliations: Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, Saitama 359-1192, Japan
  • Pages: 201-208
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/or.17.1.201
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Abstract

The apoptotic effects of 2-amino-4,4α-dihydro-4α, 7-dimethyl-3H-phenoxazine-3-one (Phx-1) and 2-aminophenoxazine-3-one (Phx-3) on human glioblastoma cell lines, A-172 and U-251 MG were studied. These phenoxazines extensively decreased the viability of A-172 and U-251 MG cells (IC50 of Phx-1: 60 µM, in both lines; IC50 of Phx-3: 10 and 3 µM, for A-172 and U-251 cells, respectively). Phx-1 and Phx-3 increased the population of annexin V and PI double-positive cells in A-172 and U-251 MG cells, resulting in cell death at late stage apoptosis/necrosis. The activities of caspase-3/7 were greatly increased in A-172 and U-251 MG cells treated with Phx-1 or Phx-3. However, a pan-caspase inhibitor, z-VAD-fmk, failed to reverse the antiproliferative and apoptotic effects of Phx-1 and Phx-3 in both cell lines. In conclusion, Phx-1 and Phx-3 exert significant anti-cancer effects against human glioblastoma cell lines, A-172 and U-251 MG, mediated by the caspase-independent apoptotic cell death pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Shirato K, Imaizumi K, Abe A and Tomoda A: Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG. Oncol Rep 17: 201-208, 2007.
APA
Shirato, K., Imaizumi, K., Abe, A., & Tomoda, A. (2007). Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG. Oncology Reports, 17, 201-208. https://doi.org/10.3892/or.17.1.201
MLA
Shirato, K., Imaizumi, K., Abe, A., Tomoda, A."Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG". Oncology Reports 17.1 (2007): 201-208.
Chicago
Shirato, K., Imaizumi, K., Abe, A., Tomoda, A."Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG". Oncology Reports 17, no. 1 (2007): 201-208. https://doi.org/10.3892/or.17.1.201
Copy and paste a formatted citation
x
Spandidos Publications style
Shirato K, Imaizumi K, Abe A and Tomoda A: Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG. Oncol Rep 17: 201-208, 2007.
APA
Shirato, K., Imaizumi, K., Abe, A., & Tomoda, A. (2007). Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG. Oncology Reports, 17, 201-208. https://doi.org/10.3892/or.17.1.201
MLA
Shirato, K., Imaizumi, K., Abe, A., Tomoda, A."Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG". Oncology Reports 17.1 (2007): 201-208.
Chicago
Shirato, K., Imaizumi, K., Abe, A., Tomoda, A."Phenoxazine derivatives induce caspase-independent cell death in human glioblastoma cell lines, A-172 and U-251 MG". Oncology Reports 17, no. 1 (2007): 201-208. https://doi.org/10.3892/or.17.1.201
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