MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A

Yue,Xiao; Wang,Peiguo; Xu,Jun; Zhu,Yufang; Sun,Guan; Pang,Qi; Tao,Rongjie

doi:10.3892/or.2011.1588

MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A

Authors:
- Xiao Yue
- Peiguo Wang
- Jun Xu
- Yufang Zhu
- Guan Sun
- Qi Pang
- Rongjie Tao
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Affiliations: Department of Neurosurgery, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan 250117, P.R. China, Department of Neurosurgery, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jiyan Road 440, Jinan 250117, Shandong Province, P.R. China
Published online on: December 12, 2011 https://doi.org/10.3892/or.2011.1588
Pages: 1200-1206

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Abstract

MicroRNAs (miRNAs) are endogenously small non-coding RNAs which are key post-transcriptional regulators of gene expression. Deregulation of miRNAs is common in human tumorigenesis. We report that miRNA-205 is significantly down-regulated in glioma cell lines and tissue specimens. Ectopic expression of miRNA-205 induces apoptosis, cell cycle arrest, impairs cell viability, clonability and invasive properties of glioma cells. We further demonstrate that miRNA-205 can specifically suppress expression of VEGF-A by directly interacting with the putative miRNA-205 binding site at the 3'-UTR. Identification of VEGF-A as a direct target for miRNA-205 may imply that miRNA-205 is a novel target for glioma therapy. Taken together, the present study for the first time provides evidence that miRNA-205 is a glioma-specific tumor suppressor by targeting VEGF-A.

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