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Article

Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer

  • Authors:
    • Jean-Luc Brun
    • Annie Cortez
    • Bénédicte Lesieur
    • Serge Uzan
    • Roman Rouzier
    • Emile Daraï
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Hôpital Pellegrin, Place Amélie Raba Léon, F-33076 Bordeaux, France
  • Pages: 1049-1057
    |
    Published online on: December 22, 2011
       https://doi.org/10.3892/or.2011.1608
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Abstract

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to assess their prognostic value. A tissue microarray of malignant ovarian tumors from 69 patients was constructed. Immunostaining results were scored using the HSCORE and assessed by univariate analysis with Bonferroni correction and classical multidimensional scaling (CMDS). Kaplan-Meier survival curves calculated with regard to patient and tumor characteristics were compared by the log-rank test. Patients treated by primary surgery (n=43) had a higher tumor size and a trend toward higher epithelial MMP and TIMP expression than those treated by interval surgery (n=26). Optimal cytoreduction (residue ≤1 cm) was obtained in 27 and 18 patients, respectively. Clinical and histological characteristics were not different in patients with optimal cytoreduction and those with suboptimal cytoreduction. The expression of epithelial MMP-9 (P=0.002) and TIMP-2 (P=0.026) were higher in the latter group. CMDS failed to demonstrate any influence of MMP and TIMP expression with regard to cytoreduction outcome. MMP and TIMP expression did not influence survival. Their prognostic values were outweighed by histological type, lymph node involvement and cytoreduction. Standard statistical analysis adjusted after Bonferroni correction and CMDS reduced the relevance of MMPs and TIMPs in the prognosis of patients with advanced ovarian cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Brun J, Cortez A, Lesieur B, Uzan S, Rouzier R and Daraï E: Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncol Rep 27: 1049-1057, 2012.
APA
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., & Daraï, E. (2012). Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncology Reports, 27, 1049-1057. https://doi.org/10.3892/or.2011.1608
MLA
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., Daraï, E."Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer". Oncology Reports 27.4 (2012): 1049-1057.
Chicago
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., Daraï, E."Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer". Oncology Reports 27, no. 4 (2012): 1049-1057. https://doi.org/10.3892/or.2011.1608
Copy and paste a formatted citation
x
Spandidos Publications style
Brun J, Cortez A, Lesieur B, Uzan S, Rouzier R and Daraï E: Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncol Rep 27: 1049-1057, 2012.
APA
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., & Daraï, E. (2012). Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncology Reports, 27, 1049-1057. https://doi.org/10.3892/or.2011.1608
MLA
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., Daraï, E."Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer". Oncology Reports 27.4 (2012): 1049-1057.
Chicago
Brun, J., Cortez, A., Lesieur, B., Uzan, S., Rouzier, R., Daraï, E."Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer". Oncology Reports 27, no. 4 (2012): 1049-1057. https://doi.org/10.3892/or.2011.1608
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