Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer

  • Authors:
    • Yiqing Qu
    • Yie Yang
    • Dedong Ma
    • Wei Xiao
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  • Published online on: January 11, 2012     https://doi.org/10.3892/or.2012.1627
  • Pages: 1277-1283
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Abstract

Lung cancer is the most common cause of cancer-related deaths in the world. The trefoil factor (TFF) family is composed of three thermostable, and protease-resistant proteins, named TFF1, TFF2 and TFF3. TFF protein levels have been found to be related to the development of various types of cancer. However, it is still unclear whether TFF proteins are differentially expressed in the serum of different histological subtypes of lung cancer compared to healthy individuals. In this study, we investigated the levels of TFF proteins in serum and lung tissues of 130 lung cancer patients (58 squamous cell lung carcinoma cases, 43 adenocarcinoma cases and 29 SCLC cases) and 60 healthy individuals. It was found that TFF1 and TFF2 have similar or slightly higher levels in these three subtypes of lung cancer compared to healthy individuals, while TFF3 levels were significantly higher in the examined lung cancer cases compared to healthy individuals. Immunoblot analyses of TFF1, TFF2 and TFF3 indicated that lung cancer tissues and lung cancer cell lines have a higher expression of the TFF3 protein, but not of TFF1 or TFF2 proteins, compared to tissues from healthy individuals or from the normal cell line. Quantitative RT-PCR analysis indicated higher levels of TFF3, but not TFF1 and TFF2, transcripts in lung cancer tissues or cell lines. These results show increased TFF3 levels in serum and lung tissues, suggesting that TFF3 may serve as a promising, easily detected biomarker of lung cancer.
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April 2012
Volume 27 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Qu Y, Yang Y, Ma D and Xiao W: Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer. Oncol Rep 27: 1277-1283, 2012
APA
Qu, Y., Yang, Y., Ma, D., & Xiao, W. (2012). Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer. Oncology Reports, 27, 1277-1283. https://doi.org/10.3892/or.2012.1627
MLA
Qu, Y., Yang, Y., Ma, D., Xiao, W."Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer". Oncology Reports 27.4 (2012): 1277-1283.
Chicago
Qu, Y., Yang, Y., Ma, D., Xiao, W."Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer". Oncology Reports 27, no. 4 (2012): 1277-1283. https://doi.org/10.3892/or.2012.1627