Role of the ABCE1 gene in human lung adenocarcinoma

  • Authors:
    • Yi Ren
    • Yinghui Li
    • Dali Tian
  • View Affiliations

  • Published online on: January 19, 2012     https://doi.org/10.3892/or.2012.1646
  • Pages: 965-970
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Abstract

ATP-binding cassette transporter E1 (ABCE1), also known as RLI (RNase L inhibitor), is a new type of endoribonuclease inhibitor, which can specifically bind to RNase L and abolish its effect. ABCE1 binds to eIF2α and eIF5 to form a pre-translation initiation complex, suggesting its crucial role in cell growth, development and certain pathological processes. To probe the role of ABCE1 in the development and progress of human lung adenocarcinoma, we first detected the changes of its mRNA and protein expression in tissues, and found a high expression level of ABCE1 in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages. Moreover, human lung adenocarcinoma A549 cells were infected with lentiviral vectors containing ABCE1-specific shRNA, and resulted in significant inhibition of cell growth. Using microarray assay, a number of differentially expressed genes were found after ABCE1 suppression. Our results demonstrated the potential role of ABCE1 in human lung adenocarcinoma, which may provide some molecular basis for the mechanisms of development and progress of human lung adenocarcinoma, and help to find new pharmacological targets.
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April 2012
Volume 27 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ren Y, Li Y and Tian D: Role of the ABCE1 gene in human lung adenocarcinoma. Oncol Rep 27: 965-970, 2012
APA
Ren, Y., Li, Y., & Tian, D. (2012). Role of the ABCE1 gene in human lung adenocarcinoma. Oncology Reports, 27, 965-970. https://doi.org/10.3892/or.2012.1646
MLA
Ren, Y., Li, Y., Tian, D."Role of the ABCE1 gene in human lung adenocarcinoma". Oncology Reports 27.4 (2012): 965-970.
Chicago
Ren, Y., Li, Y., Tian, D."Role of the ABCE1 gene in human lung adenocarcinoma". Oncology Reports 27, no. 4 (2012): 965-970. https://doi.org/10.3892/or.2012.1646