Role of the ABCE1 gene in human lung adenocarcinoma

Ren,Yi; Li,Yinghui; Tian,Dali

doi:10.3892/or.2012.1646

April 2012 Volume 27 Issue 4

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April 2012 Volume 27 Issue 4

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Article

Role of the ABCE1 gene in human lung adenocarcinoma

Authors:
- Yi Ren
- Yinghui Li
- Dali Tian
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyan 110032, P.R. China, Department of Medical Genetics, College of Basic Medical Sciences, China Medical University, Shenyang 110001, P.R. China
Pages: 965-970
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Published online on: January 19, 2012

https://doi.org/10.3892/or.2012.1646
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Abstract

ATP-binding cassette transporter E1 (ABCE1), also known as RLI (RNase L inhibitor), is a new type of endoribonuclease inhibitor, which can specifically bind to RNase L and abolish its effect. ABCE1 binds to eIF2α and eIF5 to form a pre-translation initiation complex, suggesting its crucial role in cell growth, development and certain pathological processes. To probe the role of ABCE1 in the development and progress of human lung adenocarcinoma, we first detected the changes of its mRNA and protein expression in tissues, and found a high expression level of ABCE1 in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages. Moreover, human lung adenocarcinoma A549 cells were infected with lentiviral vectors containing ABCE1-specific shRNA, and resulted in significant inhibition of cell growth. Using microarray assay, a number of differentially expressed genes were found after ABCE1 suppression. Our results demonstrated the potential role of ABCE1 in human lung adenocarcinoma, which may provide some molecular basis for the mechanisms of development and progress of human lung adenocarcinoma, and help to find new pharmacological targets.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Role of the ABCE1 gene in human lung adenocarcinoma

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