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Article

Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells

  • Authors:
    • Shudong Yu
    • Ruxin Zhang
    • Fenye Liu
    • Hong Wang
    • Jing Wu
    • Yanqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, P.R. China, Department of Integrative Medicine and Neurobiology, Shanghai Medical College, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, P.R. China
  • Pages: 561-566
    |
    Published online on: May 24, 2012
       https://doi.org/10.3892/or.2012.1830
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Abstract

The cancer stem cell (CSC) is responsible for the initiation, proliferation and radiation resistance. Side population (SP) cells are a rare subset of cells enriched with CSCs. The targeting of key signaling pathways that are active in CSCs is a therapeutic approach to treating cancer. Notch signaling is important for the self-renewal and maintenance of stem cells. Our previous studies demonstrated that downregulation of Notch signaling could enhance radiosensitivity of nasopharyngeal carcinoma (NPC) cells. In this study, we found that Notch signaling was highly activated in SP cells compared with that of non-SP (NSP) cells of NPC. Therefore, Notch inhibition could reduce the proportion of SP cells. As SP cells decreased, proliferation, anti-apoptosis and tumorigenesis were also decreased. This study shows that Notch inhibition may be a promising clinical approach in CSC-targeting therapy for NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu S, Zhang R, Liu F, Wang H, Wu J and Wang Y: Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncol Rep 28: 561-566, 2012.
APA
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., & Wang, Y. (2012). Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncology Reports, 28, 561-566. https://doi.org/10.3892/or.2012.1830
MLA
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., Wang, Y."Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells". Oncology Reports 28.2 (2012): 561-566.
Chicago
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., Wang, Y."Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells". Oncology Reports 28, no. 2 (2012): 561-566. https://doi.org/10.3892/or.2012.1830
Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Zhang R, Liu F, Wang H, Wu J and Wang Y: Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncol Rep 28: 561-566, 2012.
APA
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., & Wang, Y. (2012). Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells. Oncology Reports, 28, 561-566. https://doi.org/10.3892/or.2012.1830
MLA
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., Wang, Y."Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells". Oncology Reports 28.2 (2012): 561-566.
Chicago
Yu, S., Zhang, R., Liu, F., Wang, H., Wu, J., Wang, Y."Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells". Oncology Reports 28, no. 2 (2012): 561-566. https://doi.org/10.3892/or.2012.1830
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