Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma

Luo,Xuan; Fan,Songqing; Huang,Wenbin; Zhai,Sulan; Ma,Zhuo; Li,Ping; Sun,Shi-Yong; Wang,Xuerong

doi:10.3892/or.2012.1846

Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma

Authors:
- Xuan Luo
- Songqing Fan
- Wenbin Huang
- Sulan Zhai
- Zhuo Ma
- Ping Li
- Shi-Yong Sun
- Xuerong Wang
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Affiliations: Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, P.R. China, Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China, Department of Pathology, Nanjing Medical University Affiliated Nanjing First Hospital, Nanjing, Jiangsu, P.R. China, Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Published online on: June 1, 2012 https://doi.org/10.3892/or.2012.1846
Pages: 659-667

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Abstract

Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). To date, the role of insulin receptor substrate 1 (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated. In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. Furthermore, we found that knockdown of IRS-1 expression enhanced cell invasive potency and induced EMT in parallel with upregulation of miR-9 expression. We propose that IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9.

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