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Article

Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma

  • Authors:
    • Xuan Luo
    • Songqing Fan
    • Wenbin Huang
    • Sulan Zhai
    • Zhuo Ma
    • Ping Li
    • Shi-Yong Sun
    • Xuerong Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, P.R. China, Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, P.R. China, Department of Pathology, Nanjing Medical University Affiliated Nanjing First Hospital, Nanjing, Jiangsu, P.R. China, Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
  • Pages: 659-667
    |
    Published online on: June 1, 2012
       https://doi.org/10.3892/or.2012.1846
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Abstract

Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). To date, the role of insulin receptor substrate 1 (IRS-1) in tumorigenesis and metastasis of head and neck cancer has not been elucidated. In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. Furthermore, we found that knockdown of IRS-1 expression enhanced cell invasive potency and induced EMT in parallel with upregulation of miR-9 expression. We propose that IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9.
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Copy and paste a formatted citation
Spandidos Publications style
Luo X, Fan S, Huang W, Zhai S, Ma Z, Li P, Sun S and Wang X: Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma. Oncol Rep 28: 659-667, 2012.
APA
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P. ... Wang, X. (2012). Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma. Oncology Reports, 28, 659-667. https://doi.org/10.3892/or.2012.1846
MLA
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P., Sun, S., Wang, X."Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma". Oncology Reports 28.2 (2012): 659-667.
Chicago
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P., Sun, S., Wang, X."Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma". Oncology Reports 28, no. 2 (2012): 659-667. https://doi.org/10.3892/or.2012.1846
Copy and paste a formatted citation
x
Spandidos Publications style
Luo X, Fan S, Huang W, Zhai S, Ma Z, Li P, Sun S and Wang X: Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma. Oncol Rep 28: 659-667, 2012.
APA
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P. ... Wang, X. (2012). Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma. Oncology Reports, 28, 659-667. https://doi.org/10.3892/or.2012.1846
MLA
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P., Sun, S., Wang, X."Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma". Oncology Reports 28.2 (2012): 659-667.
Chicago
Luo, X., Fan, S., Huang, W., Zhai, S., Ma, Z., Li, P., Sun, S., Wang, X."Downregulation of IRS-1 promotes metastasis of head and neck squamous cell carcinoma". Oncology Reports 28, no. 2 (2012): 659-667. https://doi.org/10.3892/or.2012.1846
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