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Article

High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer

  • Authors:
    • Xiao-Wei Qi
    • Fan Zhang
    • Xin-Hua Yang
    • Lin-Jun Fan
    • Yi Zhang
    • Yan Liang
    • Lin Ren
    • Ling Zhong
    • Qing-Qiu Chen
    • Kong-Yong Zhang
    • Wei-Dong Zang
    • Li-Shan Wang
    • Ying Zhang
    • Jun Jiang
  • View Affiliations / Copyright

    Affiliations: Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China, College of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, P.R. China, City College of San Francisco, San Francisco, CA, USA
  • Pages: 1231-1236
    |
    Published online on: July 12, 2012
       https://doi.org/10.3892/or.2012.1906
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Abstract

The role of Wilms' tumor 1 (WT1) in breast cancer and the relationship between WT1 expression and clinicopathological factors, molecular subtypes and prognosis of breast cancer patients have not been clarified to date. We used publicly available microarray datasets of 266 early breast cancer patients to perform bioinformatics analysis on the relationship between WT1 mRNA expression and breast cancer. Results showed that WT1 mRNA expression was correlated with higher histological grades, ER-negative and basal-like and ERBB2 molecular subtypes in breast cancer. With regard to disease-free survival analysis, the WT1 high expression group showed worse prognosis than the low expression group in univariate analysis, and WT1 was demonstrated to be an independent prognostic indicator in multivariate analysis. This study confirms an oncogenic role of WT1 and demonstrates a possible relation between WT1 and progression of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Qi X, Zhang F, Yang X, Fan L, Zhang Y, Liang Y, Ren L, Zhong L, Chen Q, Zhang K, Zhang K, et al: High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer. Oncol Rep 28: 1231-1236, 2012.
APA
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y. ... Jiang, J. (2012). High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer. Oncology Reports, 28, 1231-1236. https://doi.org/10.3892/or.2012.1906
MLA
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y., Ren, L., Zhong, L., Chen, Q., Zhang, K., Zang, W., Wang, L., Zhang, Y., Jiang, J."High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer". Oncology Reports 28.4 (2012): 1231-1236.
Chicago
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y., Ren, L., Zhong, L., Chen, Q., Zhang, K., Zang, W., Wang, L., Zhang, Y., Jiang, J."High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer". Oncology Reports 28, no. 4 (2012): 1231-1236. https://doi.org/10.3892/or.2012.1906
Copy and paste a formatted citation
x
Spandidos Publications style
Qi X, Zhang F, Yang X, Fan L, Zhang Y, Liang Y, Ren L, Zhong L, Chen Q, Zhang K, Zhang K, et al: High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer. Oncol Rep 28: 1231-1236, 2012.
APA
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y. ... Jiang, J. (2012). High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer. Oncology Reports, 28, 1231-1236. https://doi.org/10.3892/or.2012.1906
MLA
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y., Ren, L., Zhong, L., Chen, Q., Zhang, K., Zang, W., Wang, L., Zhang, Y., Jiang, J."High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer". Oncology Reports 28.4 (2012): 1231-1236.
Chicago
Qi, X., Zhang, F., Yang, X., Fan, L., Zhang, Y., Liang, Y., Ren, L., Zhong, L., Chen, Q., Zhang, K., Zang, W., Wang, L., Zhang, Y., Jiang, J."High Wilms' tumor 1 mRNA expression correlates with basal-like and ERBB2 molecular subtypes and poor prognosis of breast cancer". Oncology Reports 28, no. 4 (2012): 1231-1236. https://doi.org/10.3892/or.2012.1906
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