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October 2012 Volume 28 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression

  • Authors:
    • Hongtao Wang
    • Ruiqin Wu
    • Lan Yu
    • Feima Wu
    • Shanhu Li
    • Yali Zhao
    • Hailiang Li
    • Guolan Luo
    • Jian Wang
    • Jianguang Zhou
  • View Affiliations / Copyright

    Affiliations: Laboratory of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing, P.R. China
  • Pages: 1468-1474
    |
    Published online on: July 19, 2012
       https://doi.org/10.3892/or.2012.1917
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Abstract

The purpose of this study was to investigate the potential roles of the SH3-containing guanine nucleotide exchange factor (SGEF) in human prostate cancer. Experimental data showed that SGEF was overexpressed in human prostate cancer cells and specimens. The reduction of SGEF expression through an SGEF-targeting siRNA in androgen-independent C4-2 and C4-2B cells suppressed both anchorage-dependent and anchorage-independent growth. In addition, the androgen receptor (AR) antagonist bicalutamide further strengthened this inhibitory effect due to the suppression of the elevated AR transactivation after knockdown of SGEF. Collectively, our results provide the first demonstration that SGEF is a novel promoter of human prostate cancer progression and development.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wu R, Yu L, Wu F, Li S, Zhao Y, Li H, Luo G, Wang J, Zhou J, Zhou J, et al: SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncol Rep 28: 1468-1474, 2012.
APA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y. ... Zhou, J. (2012). SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncology Reports, 28, 1468-1474. https://doi.org/10.3892/or.2012.1917
MLA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28.4 (2012): 1468-1474.
Chicago
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28, no. 4 (2012): 1468-1474. https://doi.org/10.3892/or.2012.1917
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wu R, Yu L, Wu F, Li S, Zhao Y, Li H, Luo G, Wang J, Zhou J, Zhou J, et al: SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncol Rep 28: 1468-1474, 2012.
APA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y. ... Zhou, J. (2012). SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncology Reports, 28, 1468-1474. https://doi.org/10.3892/or.2012.1917
MLA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28.4 (2012): 1468-1474.
Chicago
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28, no. 4 (2012): 1468-1474. https://doi.org/10.3892/or.2012.1917
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