SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression

  • Authors:
    • Hongtao Wang
    • Ruiqin Wu
    • Lan Yu
    • Feima Wu
    • Shanhu Li
    • Yali Zhao
    • Hailiang Li
    • Guolan Luo
    • Jian Wang
    • Jianguang Zhou
  • View Affiliations

  • Published online on: July 19, 2012     https://doi.org/10.3892/or.2012.1917
  • Pages: 1468-1474
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Abstract

The purpose of this study was to investigate the potential roles of the SH3-containing guanine nucleotide exchange factor (SGEF) in human prostate cancer. Experimental data showed that SGEF was overexpressed in human prostate cancer cells and specimens. The reduction of SGEF expression through an SGEF-targeting siRNA in androgen-independent C4-2 and C4-2B cells suppressed both anchorage-dependent and anchorage-independent growth. In addition, the androgen receptor (AR) antagonist bicalutamide further strengthened this inhibitory effect due to the suppression of the elevated AR transactivation after knockdown of SGEF. Collectively, our results provide the first demonstration that SGEF is a novel promoter of human prostate cancer progression and development.
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October 2012
Volume 28 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wang H, Wu R, Yu L, Wu F, Li S, Zhao Y, Li H, Luo G, Wang J, Zhou J, Zhou J, et al: SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncol Rep 28: 1468-1474, 2012.
APA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y. ... Zhou, J. (2012). SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Oncology Reports, 28, 1468-1474. https://doi.org/10.3892/or.2012.1917
MLA
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28.4 (2012): 1468-1474.
Chicago
Wang, H., Wu, R., Yu, L., Wu, F., Li, S., Zhao, Y., Li, H., Luo, G., Wang, J., Zhou, J."SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression". Oncology Reports 28, no. 4 (2012): 1468-1474. https://doi.org/10.3892/or.2012.1917