Hepatitis B virus X protein plays an important role in gastric ulcers

Guo,Peng-Tao; Yang,Dong; Sun,Zhe; Xu,Hui-Mian

doi:10.3892/or.2012.2011

Hepatitis B virus X protein plays an important role in gastric ulcers

Authors:
- Peng-Tao Guo
- Dong Yang
- Zhe Sun
- Hui-Mian Xu
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Affiliations: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China, Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China
Published online on: September 3, 2012 https://doi.org/10.3892/or.2012.2011
Pages: 1653-1658

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Abstract

Hepatitis B virus (HBV) infects many individuals globally each year. Researchers usually focus on the relationship between HBV and liver diseases. In this study, we investigated the effects of HBV infection on gastric mucosa. We detected the levels of HBX protein and mRNA in specimens from sixty-four chronic hepatitis B patients (CHB) with gastric ulcers. We confirmed that HBX could aggravate gastric ulcers according to clinicopathological parameters. In addition, we constructed the pcDNA3.1-HBX plasmid and transfected it into GES-1, a gastric mucosal cell line. The results indicated that HBX could induce apoptosis and G1 arrest in GES-1 cells. Insights into the mechanism of HBX action in GES-1 cells were obtained using western blot analysis.

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