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Article

Hepatitis B virus X protein plays an important role in gastric ulcers

  • Authors:
    • Peng-Tao Guo
    • Dong Yang
    • Zhe Sun
    • Hui-Mian Xu
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China, Department of General Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, P.R. China
  • Pages: 1653-1658
    |
    Published online on: September 3, 2012
       https://doi.org/10.3892/or.2012.2011
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Abstract

Hepatitis B virus (HBV) infects many individuals globally each year. Researchers usually focus on the relationship between HBV and liver diseases. In this study, we investigated the effects of HBV infection on gastric mucosa. We detected the levels of HBX protein and mRNA in specimens from sixty-four chronic hepatitis B patients (CHB) with gastric ulcers. We confirmed that HBX could aggravate gastric ulcers according to clinicopathological parameters. In addition, we constructed the pcDNA3.1-HBX plasmid and transfected it into GES-1, a gastric mucosal cell line. The results indicated that HBX could induce apoptosis and G1 arrest in GES-1 cells. Insights into the mechanism of HBX action in GES-1 cells were obtained using western blot analysis.
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Copy and paste a formatted citation
Spandidos Publications style
Guo P, Yang D, Sun Z and Xu H: Hepatitis B virus X protein plays an important role in gastric ulcers. Oncol Rep 28: 1653-1658, 2012.
APA
Guo, P., Yang, D., Sun, Z., & Xu, H. (2012). Hepatitis B virus X protein plays an important role in gastric ulcers. Oncology Reports, 28, 1653-1658. https://doi.org/10.3892/or.2012.2011
MLA
Guo, P., Yang, D., Sun, Z., Xu, H."Hepatitis B virus X protein plays an important role in gastric ulcers". Oncology Reports 28.5 (2012): 1653-1658.
Chicago
Guo, P., Yang, D., Sun, Z., Xu, H."Hepatitis B virus X protein plays an important role in gastric ulcers". Oncology Reports 28, no. 5 (2012): 1653-1658. https://doi.org/10.3892/or.2012.2011
Copy and paste a formatted citation
x
Spandidos Publications style
Guo P, Yang D, Sun Z and Xu H: Hepatitis B virus X protein plays an important role in gastric ulcers. Oncol Rep 28: 1653-1658, 2012.
APA
Guo, P., Yang, D., Sun, Z., & Xu, H. (2012). Hepatitis B virus X protein plays an important role in gastric ulcers. Oncology Reports, 28, 1653-1658. https://doi.org/10.3892/or.2012.2011
MLA
Guo, P., Yang, D., Sun, Z., Xu, H."Hepatitis B virus X protein plays an important role in gastric ulcers". Oncology Reports 28.5 (2012): 1653-1658.
Chicago
Guo, P., Yang, D., Sun, Z., Xu, H."Hepatitis B virus X protein plays an important role in gastric ulcers". Oncology Reports 28, no. 5 (2012): 1653-1658. https://doi.org/10.3892/or.2012.2011
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