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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2012 Volume 28 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Clinical significance of wall invasion pattern of subserosa-invasive gallbladder carcinoma

Ken-Ichi Okada, Hiroshi Kijima, Toshihide Imaizumi, Kenichi Hirabayashi, Masahiro Matsuyama, Naoki Yazawa, Shoichi Dowaki, Kosuke Tobita, Yasuo Ohtani, Makiko Tanaka, Sadaki Inokuchi, Hiroyasu Makuuchi
Pages: 1531-1536
Published online on: 10 August 2012

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Article Open Access

Relationship of lower uterine segment cancer with Lynch syndrome: A novel case with an hMLH1 germline mutation

Kenta Masuda, Kouji Banno, Akira Hirasawa, Megumi Yanokura, Kosuke Tsuji, Yusuke Kobayashi, Iori Kisu, Arisa Ueki, Hiroyuki Nomura, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki
Pages: 1537-1543
Published online on: 31 August 2012

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Article Open Access

Thyroid transcription factor 1 represses the expression of Ki-67 and induces apoptosis in non-small cell lung cancer

Yun-Fen Zu, Xi-Cai Wang, Yan Chen, Ji-Ying Wang, Xin Liu, Xin Li, Cheng-Wen Li, Yu-Cheng Xie, Yan Luo, Xie-Qin Shang, Jing Guo
Pages: 1544-1550
Published online on: 31 August 2012

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Article Open Access

Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines

Mitsuru Chiba, Misako Kimura, Saya Asari
Pages: 1551-1558
Published online on: 10 August 2012

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Article Open Access

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours

Alessandra Capodanno, Laura Boldrini, Greta Alì, Serena Pelliccioni, Alfredo Mussi, Gabriella Fontanini
Pages: 1559-1566
Published online on: 04 September 2012

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Article Open Access

siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells

Anna Nasulewicz-Goldeman, Barbara Uszczyńska, Katarzyna Szczaurska-Nowak, Joanna Wietrzyk
Pages: 1567-1573
Published online on: 10 August 2012

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Article Open Access

Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation

Naoto Sato, Yasushi Saga, Hiroaki Mizukami, Dongdong Wang, Suzuyo Takahashi, Hiroaki Nonaka, Hiroyuki Fujiwara, Yuji Takei, Shizuo Machida, Osamu Takikawa, Keiya Ozawa, Mitsuaki Suzuki
Pages: 1574-1578
Published online on: 23 August 2012

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Article

The prognostic value of KRAS mutations in patients with colorectal cancer

Yasuhiro Inoue, Susumu Saigusa, Takashi Iwata, Yoshinaga Okugawa, Yuji Toiyama, Koji Tanaka, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki
Pages: 1579-1584
Published online on: 21 August 2012

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Article

Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells

Koji Yamanegi, Junko Yamane, Kenta Kobayashi, Hideki Ohyama, Keiji Nakasho, Naoko Yamada, Masaki Hata, Satoru Fukunaga, Hiroyuki Futani, Haruki Okamura, Nobuyuki Terada
Pages: 1585-1590
Published online on: 22 August 2012

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Article

Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions

Stefan C. Genet, Junko Maeda, Hiroshi Fujisawa, Charles R. Yurkon, Yoshihiro Fujii, Ashley M. Romero, Paula C. Genik, Akira Fujimori, Hisashi Kitamura, Takamitsu A. Kato
Pages: 1591-1596
Published online on: 22 August 2012

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Article

Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis

Yoshio Araki, Tadao Bamba, Ken-Ichi Mukaisho, Osamu Kanauchi, Hiromitsu Ban, Shigeki Bamba, Akira Andoh, Yoshihide Fujiyama, Takanori Hattori, Hiroyuki Sugihara
Pages: 1597-1605
Published online on: 10 August 2012

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Article

Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: Report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology

Rin Yamaguchi, Shin-Ιchi Tsuchiya, Takashi Koshikawa, Akinori Ishihara, Shinobu Masuda, Ichiro Maeda, Masafumi Takimoto, Masashi Kawamoto, Haruaki Satoh, Michihiko Narita, Hitoshi Itoh, Takashi Kitamura, Yoshiko Tsuda, Naoki Ogane, Eiji Abe, Katsuhide Ikeda, Takeshi Nakamura, Harumi Kamaguchi, Yoshiro Tokoro
Pages: 1606-1612
Published online on: 03 September 2012

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Article

Simultaneous knockdown of APRIL via multiple shRNAs reduces the malignancy of SW480 cells

Haiquan Li, Keke Shao, Jingchun Wang, Guihua Wang, Jin Xu, Jinde Cao, Shaoqing Ju, Huimin Wang
Pages: 1613-1618
Published online on: 22 August 2012

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Article

Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma

Johannes C. Lauscher, Sefer Elezkurtaj, Sonja Dullat, Sybille Lipka, Jörn Gröne, Heinz J. Buhr, Otmar Huber, Martin Kruschewski
Pages: 1619-1624
Published online on: 10 August 2012

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Article

Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer

Dan Xiong, Yun-Lin Ye, Ming-Kun Chen, Zi-Ke Qin, Man-Zhi Li, Hua Zhang, Li-Hua Xu, Zhen-Zhou Xu, Mu-Sheng Zeng
Pages: 1625-1632
Published online on: 10 August 2012

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Article

Aquaporin-4 upregulated expression in glioma tissue is a reaction to glioma-associated edema induced by vascular endothelial growth factor

Lijuan Yang, Xingfu Wang, Shiming Zhen, Sheng Zhang, Dezhi Kang, Zhixiong Lin
Pages: 1633-1638
Published online on: 21 August 2012

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Article

IDH1 mutation of gliomas with long-term survival analysis

Jae Kyung Myung, Hwa Jin Cho, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sung-Hye Park
Pages: 1639-1644
Published online on: 24 August 2012

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Article

Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy

Morito Sugimoto, Masami Watanabe, Haruki Kaku, Shun-Ai Li, Hirofumi Noguchi, Hideo Ueki, Masakiyo Sakaguchi, Nam-Ho Huh, Yasutomo Nasu, Hiromi Kumon
Pages: 1645-1652
Published online on: 30 August 2012

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Article

Hepatitis B virus X protein plays an important role in gastric ulcers

Peng-Tao Guo, Dong Yang, Zhe Sun, Hui-Mian Xu
Pages: 1653-1658
Published online on: 03 September 2012

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Article

Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck

Liangliang Yang, Fayu Liu, Zhongfei Xu, Nan Guo, Xiaojiao Zheng, Changfu Sun
Pages: 1659-1664
Published online on: 23 August 2012

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Article

Enhanced proliferation of human hepatoma cells by PAR-2 agonists via the ERK/AP-1 pathway

Liqun Xie, Yanmin Zheng, Xuan Li, Junyan Zhao, Xiaoyi Chen, Li Chen, Jing Zhou, Ou Hai, Fei Li
Pages: 1665-1672
Published online on: 31 August 2012

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Article

GFP/HPV-16E6 fusion protein induces apoptosis in MCF-7 and 293T cells using a transient expression system

Ge Zhang, Yan Liu, Liwei Yu, Lina Sun
Pages: 1673-1680
Published online on: 22 August 2012

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Article

Tetrandrine enhances cytotoxicity of cisplatin in human drug-resistant esophageal squamous carcinoma cells by inhibition of multidrug resistance-associated protein 1

Tian Hu Wang, Jing Yuan Wan, Xia Gong, Hong Zhong Li, Yuan Cheng
Pages: 1681-1686
Published online on: 30 August 2012

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Article

Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo

Peng Sun, Hong Yu, Wen-Qing Zhang, Ming Hu, Rui Lv
Pages: 1687-1692
Published online on: 10 August 2012

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Article

The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway

Da-Peng Duan, Xiao-Qian Dang, Kun-Zheng Wang, Yong-Ping Wang, Hui Zhang, Wu-Lin You
Pages: 1693-1700
Published online on: 24 August 2012

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Article

Expression of endothelial cell-specific molecule-1 regulated by hypoxia inducible factor-1α in human colon carcinoma: Impact of ESM-1 on prognosis and its correlation with clinicopathological features

Joo Heon Kim, Mee Young Park, Chang Nam Kim, Kyo Hyun Kim, Ho Bum Kang, Kwang Dong Kim, Jae Wha Kim
Pages: 1701-1708
Published online on: 03 September 2012

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Article

ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway

Jianli Guo, Lei He, Ping Yuan, Peng Wang, Yanjun Lu, Fangli Tong, Yu Wang, Yanhua Yin, Jun Tian, Jun Sun
Pages: 1709-1718
Published online on: 30 August 2012

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Article

Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells

Jie Ren, Hong Cheng, Wen Qun Xin, Xin Chen, Kun Hu
Pages: 1719-1726
Published online on: 04 September 2012

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Article

Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancer

Tetsuhiro Nakano, Kimihiro Shimizu, Osamu Kawashima, Mitsuhiro Kamiyoshihara, Seiichi Kakegawa, Masayuki Sugano, Takashi Ibe, Toshiteru Nagashima, Kyoichi Kaira, Noriaki Sunaga, Youichi Ohtaki, Jun Atsumi, Izumi Takeyoshi
Pages: 1727-1735
Published online on: 21 August 2012

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Article

Molecular imaging and therapeutic efficacy of 188Re-(DXR)-liposome-BBN in AR42J pancreatic tumor-bearing mice

Ya-Jen Chang, Chia-Yu Yu, Chin-Wei Hsu, Wan-Chi Lee, Su-Jung Chen, Chih-Hsien Chang, Te-Wei Lee
Pages: 1736-1742
Published online on: 22 August 2012

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Article

In vivo distribution and antitumor effect of infused immune cells in a gastric cancer model

Xiaohui Du, Runsen Jin, Ning Ning, Li Li, Quansheng  Wang, Wentao Liang, Juchao Liu, Yingxin Xu
Pages: 1743-1749
Published online on: 03 September 2012

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Article

The distribution of human papillomavirus in tissues from patients with head and neck squamous cell carcinoma

Wei Wei, Qi Shi, Fei Guo, Bao-Yun Zhang, Cao Chen, Nai-Song Zhang, Xiao-Ping Dong
Pages: 1750-1756
Published online on: 24 August 2012

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Article

Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells

Hye Jeong Kim, Min Ho Han, Gi Young Kim, Young-Whan Choi, Yung Hyun Choi
Pages: 1757-1763
Published online on: 23 August 2012

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Article

miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma

Cheng-Kui Cai, Guang-Yi Zhao, Li-Ying Tian, Lie Liu, Kang Yan, Yun-Lei Ma, Zhen-Wei Ji, Xiao-Xiang Li, Kang Han, Jie Gao, Xiu-Chun Qiu, Qing-Yu Fan, Tong-Tao Yang, Bao-An Ma
Pages: 1764-1770
Published online on: 24 August 2012

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Article

miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11 Corrigendum in /or/32/3/1319

Huanjiang Niu, Kun Wang, Anling Zhang, Shuxu Yang, Zhengfei Song, Wei Wang, Cong Qian, Xinwei Li, Yinxin Zhu, Yirong Wang
Pages: 1771-1777
Published online on: 10 August 2012

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Article

Lentivirus-mediated short-hairpin RNA targeting IGF-1R inhibits growth and lymphangiogenesis in breast cancer

Yaning Chen, Chenfang Zhu, Zhiyou Peng, Yalei Dai, Yan Gu
Pages: 1778-1784
Published online on: 10 August 2012

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Article

Frequent silencing of protocadherin 8 by promoter methylation, a candidate tumor suppressor for human gastric cancer

Danjie Zhang, Wei Zhao, Xinhua Liao, Tieqiang Bi, Haijun Li, Xiangming Che
Pages: 1785-1791
Published online on: 30 August 2012

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Article

Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma

Myung-Ha Song, Kyung-Un Choi, Dong-Hoon Shin, Chang-Hun Lee, Sang-Yull Lee
Pages: 1792-1798
Published online on: 30 August 2012

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Article

Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2

Chia-Ming Chang, Pei-Ying Chang, Ming-Gene Tu, Chi-Cheng Lu, Sheng-Chu Kuo, Sakae Amagaya, Chao-Ying Lee, Hui-Yu Jao, Michael Yuanchien Chen, Jai-Sing Yang
Pages: 1799-1807
Published online on: 24 August 2012

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Article

Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration

Chang-I Kung, Cheng-Yi Chen, Chih-Chang Yang, Cheng-Yu Lin, Tien-Hua Chen, Hwai-Shi Wang
Pages: 1808-1814
Published online on: 24 August 2012

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Article

Direct serum and tissue assay for EGFR mutation in non-small cell lung cancer by high-resolution melting analysis

Chengjin Hu, Xiaolei Liu, Yingjian Chen, Xiaoming Sun, Yanwen Gong, Ming Geng, Liquan Bi
Pages: 1815-1821
Published online on: 23 August 2012

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Article

In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy

Koji Tanaka, Masato Okigami, Yuji Toiyama, Yuki Morimoto, Kohei Matsushita, Mikio Kawamura, Kiyoshi Hashimoto, Susumu Saigusa, Yoshinaga Okugawa, Yasuhiro Inoue, Keiichi Uchida, Toshimitsu Araki, Yasuhiko Mohri, Akira Mizoguchi, Masato Kusunoki
Pages: 1822-1830
Published online on: 23 August 2012

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Article

miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells

Shuai Huang, Wei Guo, Yubo Tang, Dong Ren, Xuenong Zou, Xinsheng Peng
Pages: 1831-1837
Published online on: 04 September 2012

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Article

Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors

Dorota Zurawa-Janicka, Jarosław Kobiela, Natalia Galczynska, Tomasz Stefaniak, Barbara Lipinska, Andrzej Lachinski, Joanna Skorko-Glonek, Joanna Narkiewicz, Monika Proczko-Markuszewska, Zbigniew Sledzinski
Pages: 1838-1844
Published online on: 23 August 2012

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Article

Proteomic differential display identifies upregulated vinculin as a possible biomarker of pancreatic cancer

Yufeng Wang, Yasuhiro Kuramitsu, Tomio Ueno, Nobuaki Suzuki, Shigefumi Yoshino, Norio Iizuka, Xiulian Zhang, Junko Akada, Masaaki Oka, Kazuyuki Nakamura
Pages: 1845-1850
Published online on: 30 August 2012

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Article

Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways

Nicole A. Doudican, Shih Ya Wen, Amitabha Mazumder, Seth J. Orlow
Pages: 1851-1858
Published online on: 22 August 2012

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Article

Polymorphisms in base excision repair genes and thyroid cancer risk

Luís S. Santos, Sandra C. Branco, Susana N. Silva, Ana Paula Azevedo, Octávia M. Gil, Isabel Manita, Teresa C. Ferreira, Edward Limbert, José Rueff, Jorge F. Gaspar
Pages: 1859-1868
Published online on: 22 August 2012

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Article

Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells

Yeoun-Hee Kim, Jae-Chang Jung
Pages: 1869-1874
Published online on: 23 August 2012

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Article

Granulocyte colony-stimulating factor potentiates differentiation induction by all-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A

Noriyoshi Iriyama, Bo Yuan, Yoshihiro Hatta, Akira Horikoshi, Yuta Yoshino, Hiroo Toyoda, Shin Aizawa, Jin Takeuchi
Pages: 1875-1882
Published online on: 31 August 2012

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Article

Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

Chao-Ying Lee, Yung-Shin Chien, Tai-Hui Chiu, Wen-Wen Huang, Chi-Cheng Lu, Jo-Hua Chiang, Jai-Sing Yang
Pages: 1883-1888
Published online on: 30 August 2012

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Article

Yes is a central mediator of cell growth in malignant mesothelioma cells

Ayami Sato, Miki Sekine, Nantiga Virgona, Masako Ota, Tomohiro Yano
Pages: 1889-1893
Published online on: 03 September 2012

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Article

Radiosensitizing effects of arsenic trioxide on MCF-7 human breast cancer cells exposed to 89strontium chloride

Hengchao Liu, Xinquan Tao, Fang Ma, Jun Qiu, Cuiping Wu, Mingming Wang
Pages: 1894-1902
Published online on: 22 August 2012

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Article

17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion

Katarzyna Miekus, Jacek Kijowski, Małgorzata Sekuła, Marcin Majka
Pages: 1903-1903
Published online on: 27 August 2012

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Article

Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2

Yong-Sik Kim, Eun-Ae Kim, Kyu-Gun Park, Sung-Jun Lee, Mi-Sun Kim, Ho-Yong Sohn, Tae-Jin Lee
Pages: 1910-1916
Published online on: 09 August 2012

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Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells

Cheng Zhang, Guang-Rong Gao, Chen-Guang Lv, Boa-Lei Zhang, Zhi-Li Zhang, Xue-Feng Zhang
Pages: 1917-1923
Published online on: 30 August 2012

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Article

TRIAD1 is negatively regulated by the MDM2 E3 ligase

Seunghee Bae, Jin Hyuk Jung, In-Sook An, Ok-Yeoun Kim, Myoung Joo Lee, Jae Ho Lee, In-Chul Park, Su-Jae Lee, Sungkwan An
Pages: 1924-1928
Published online on: 31 August 2012

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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