Journal Articles

Open Access

Clinical significance of wall invasion pattern of subserosa-invasive gallbladder carcinoma

Ken-Ichi Okada, Hiroshi Kijima, Toshihide Imaizumi, Kenichi Hirabayashi, Masahiro Matsuyama, Naoki Yazawa, Shoichi Dowaki, Kosuke Tobita, Yasuo Ohtani, Makiko Tanaka, Sadaki Inokuchi, Hiroyasu Makuuchi

Pages: 1531-1536 Published online on: 10 August 2012
Open Access

Relationship of lower uterine segment cancer with Lynch syndrome: A novel case with an hMLH1 germline mutation

Kenta Masuda, Kouji Banno, Akira Hirasawa, Megumi Yanokura, Kosuke Tsuji, Yusuke Kobayashi, Iori Kisu, Arisa Ueki, Hiroyuki Nomura, Eiichiro Tominaga, Nobuyuki Susumu, Daisuke Aoki

Pages: 1537-1543 Published online on: 31 August 2012
Open Access

Thyroid transcription factor 1 represses the expression of Ki-67 and induces apoptosis in non-small cell lung cancer

Yun-Fen Zu, Xi-Cai Wang, Yan Chen, Ji-Ying Wang, Xin Liu, Xin Li, Cheng-Wen Li, Yu-Cheng Xie, Yan Luo, Xie-Qin Shang, Jing Guo

Pages: 1544-1550 Published online on: 31 August 2012
Open Access

Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours

Alessandra Capodanno, Laura Boldrini, Greta Alì, Serena Pelliccioni, Alfredo Mussi, Gabriella Fontanini

Pages: 1559-1566 Published online on: 04 September 2012
Open Access

siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells

Anna Nasulewicz-Goldeman, Barbara Uszczyńska, Katarzyna Szczaurska-Nowak, Joanna Wietrzyk

Pages: 1567-1573 Published online on: 10 August 2012
Open Access

Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation

Naoto Sato, Yasushi Saga, Hiroaki Mizukami, Dongdong Wang, Suzuyo Takahashi, Hiroaki Nonaka, Hiroyuki Fujiwara, Yuji Takei, Shizuo Machida, Osamu Takikawa, Keiya Ozawa, Mitsuaki Suzuki

Pages: 1574-1578 Published online on: 23 August 2012

The prognostic value of KRAS mutations in patients with colorectal cancer

Yasuhiro Inoue, Susumu Saigusa, Takashi Iwata, Yoshinaga Okugawa, Yuji Toiyama, Koji Tanaka, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki

Pages: 1579-1584 Published online on: 21 August 2012

Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells

Koji Yamanegi, Junko Yamane, Kenta Kobayashi, Hideki Ohyama, Keiji Nakasho, Naoko Yamada, Masaki Hata, Satoru Fukunaga, Hiroyuki Futani, Haruki Okamura, Nobuyuki Terada

Pages: 1585-1590 Published online on: 22 August 2012

Comparison of cellular lethality in DNA repair-proficient or -deficient cell lines resulting from exposure to 70 MeV/n protons or 290 MeV/n carbon ions

Stefan C. Genet, Junko Maeda, Hiroshi Fujisawa, Charles R. Yurkon, Yoshihiro Fujii, Ashley M. Romero, Paula C. Genik, Akira Fujimori, Hisashi Kitamura, Takamitsu A. Kato

Pages: 1591-1596 Published online on: 22 August 2012

Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis

Yoshio Araki, Tadao Bamba, Ken-Ichi Mukaisho, Osamu Kanauchi, Hiromitsu Ban, Shigeki Bamba, Akira Andoh, Yoshihide Fujiyama, Takanori Hattori, Hiroyuki Sugihara

Pages: 1597-1605 Published online on: 10 August 2012

Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: Report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology

Rin Yamaguchi, Shin-Ιchi Tsuchiya, Takashi Koshikawa, Akinori Ishihara, Shinobu Masuda, Ichiro Maeda, Masafumi Takimoto, Masashi Kawamoto, Haruaki Satoh, Michihiko Narita, Hitoshi Itoh, Takashi Kitamura, Yoshiko Tsuda, Naoki Ogane, Eiji Abe, Katsuhide Ikeda, Takeshi Nakamura, Harumi Kamaguchi, Yoshiro Tokoro

Pages: 1606-1612 Published online on: 03 September 2012

Simultaneous knockdown of APRIL via multiple shRNAs reduces the malignancy of SW480 cells

Haiquan Li, Keke Shao, Jingchun Wang, Guihua Wang, Jin Xu, Jinde Cao, Shaoqing Ju, Huimin Wang

Pages: 1613-1618 Published online on: 22 August 2012

Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma

Johannes C. Lauscher, Sefer Elezkurtaj, Sonja Dullat, Sybille Lipka, Jörn Gröne, Heinz J. Buhr, Otmar Huber, Martin Kruschewski

Pages: 1619-1624 Published online on: 10 August 2012

Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer

Dan Xiong, Yun-Lin Ye, Ming-Kun Chen, Zi-Ke Qin, Man-Zhi Li, Hua Zhang, Li-Hua Xu, Zhen-Zhou Xu, Mu-Sheng Zeng

Pages: 1625-1632 Published online on: 10 August 2012

Aquaporin-4 upregulated expression in glioma tissue is a reaction to glioma-associated edema induced by vascular endothelial growth factor

Lijuan Yang, Xingfu Wang, Shiming Zhen, Sheng Zhang, Dezhi Kang, Zhixiong Lin

Pages: 1633-1638 Published online on: 21 August 2012

IDH1 mutation of gliomas with long-term survival analysis

Jae Kyung Myung, Hwa Jin Cho, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sung-Hye Park

Pages: 1639-1644 Published online on: 24 August 2012

Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy

Morito Sugimoto, Masami Watanabe, Haruki Kaku, Shun-Ai Li, Hirofumi Noguchi, Hideo Ueki, Masakiyo Sakaguchi, Nam-Ho Huh, Yasutomo Nasu, Hiromi Kumon

Pages: 1645-1652 Published online on: 30 August 2012

Hepatitis B virus X protein plays an important role in gastric ulcers

Peng-Tao Guo, Dong Yang, Zhe Sun, Hui-Mian Xu

Pages: 1653-1658 Published online on: 03 September 2012

Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck

Liangliang Yang, Fayu Liu, Zhongfei Xu, Nan Guo, Xiaojiao Zheng, Changfu Sun

Pages: 1659-1664 Published online on: 23 August 2012

Enhanced proliferation of human hepatoma cells by PAR-2 agonists via the ERK/AP-1 pathway

Liqun Xie, Yanmin Zheng, Xuan Li, Junyan Zhao, Xiaoyi Chen, Li Chen, Jing Zhou, Ou Hai, Fei Li

Pages: 1665-1672 Published online on: 31 August 2012

GFP/HPV-16E6 fusion protein induces apoptosis in MCF-7 and 293T cells using a transient expression system

Ge Zhang, Yan Liu, Liwei Yu, Lina Sun

Pages: 1673-1680 Published online on: 22 August 2012

Tetrandrine enhances cytotoxicity of cisplatin in human drug-resistant esophageal squamous carcinoma cells by inhibition of multidrug resistance-associated protein 1

Tian Hu Wang, Jing Yuan Wan, Xia Gong, Hong Zhong Li, Yuan Cheng

Pages: 1681-1686 Published online on: 30 August 2012

Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo

Peng Sun, Hong Yu, Wen-Qing Zhang, Ming Hu, Rui Lv

Pages: 1687-1692 Published online on: 10 August 2012

The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway

Da-Peng Duan, Xiao-Qian Dang, Kun-Zheng Wang, Yong-Ping Wang, Hui Zhang, Wu-Lin You

Pages: 1693-1700 Published online on: 24 August 2012

Expression of endothelial cell-specific molecule-1 regulated by hypoxia inducible factor-1α in human colon carcinoma: Impact of ESM-1 on prognosis and its correlation with clinicopathological features

Joo Heon Kim, Mee Young Park, Chang Nam Kim, Kyo Hyun Kim, Ho Bum Kang, Kwang Dong Kim, Jae Wha Kim

Pages: 1701-1708 Published online on: 03 September 2012

ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and invasion through the activation of the Notch1 signaling pathway

Jianli Guo, Lei He, Ping Yuan, Peng Wang, Yanjun Lu, Fangli Tong, Yu Wang, Yanhua Yin, Jun Tian, Jun Sun

Pages: 1709-1718 Published online on: 30 August 2012

Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells

Jie Ren, Hong Cheng, Wen Qun Xin, Xin Chen, Kun Hu

Pages: 1719-1726 Published online on: 04 September 2012

Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancer

Tetsuhiro Nakano, Kimihiro Shimizu, Osamu Kawashima, Mitsuhiro Kamiyoshihara, Seiichi Kakegawa, Masayuki Sugano, Takashi Ibe, Toshiteru Nagashima, Kyoichi Kaira, Noriaki Sunaga, Youichi Ohtaki, Jun Atsumi, Izumi Takeyoshi

Pages: 1727-1735 Published online on: 21 August 2012

Molecular imaging and therapeutic efficacy of 188Re-(DXR)-liposome-BBN in AR42J pancreatic tumor-bearing mice

Ya-Jen Chang, Chia-Yu Yu, Chin-Wei Hsu, Wan-Chi Lee, Su-Jung Chen, Chih-Hsien Chang, Te-Wei Lee

Pages: 1736-1742 Published online on: 22 August 2012

In vivo distribution and antitumor effect of infused immune cells in a gastric cancer model

Xiaohui Du, Runsen Jin, Ning Ning, Li Li, Quansheng  Wang, Wentao Liang, Juchao Liu, Yingxin Xu

Pages: 1743-1749 Published online on: 03 September 2012

The distribution of human papillomavirus in tissues from patients with head and neck squamous cell carcinoma

Wei Wei, Qi Shi, Fei Guo, Bao-Yun Zhang, Cao Chen, Nai-Song Zhang, Xiao-Ping Dong

Pages: 1750-1756 Published online on: 24 August 2012

Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells

Hye Jeong Kim, Min Ho Han, Gi Young Kim, Young-Whan Choi, Yung Hyun Choi

Pages: 1757-1763 Published online on: 23 August 2012

miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma

Cheng-Kui Cai, Guang-Yi Zhao, Li-Ying Tian, Lie Liu, Kang Yan, Yun-Lei Ma, Zhen-Wei Ji, Xiao-Xiang Li, Kang Han, Jie Gao, Xiu-Chun Qiu, Qing-Yu Fan, Tong-Tao Yang, Bao-An Ma

Pages: 1764-1770 Published online on: 24 August 2012

miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11 Corrigendum in /or/32/3/1319

Huanjiang Niu, Kun Wang, Anling Zhang, Shuxu Yang, Zhengfei Song, Wei Wang, Cong Qian, Xinwei Li, Yinxin Zhu, Yirong Wang

Pages: 1771-1777 Published online on: 10 August 2012

Lentivirus-mediated short-hairpin RNA targeting IGF-1R inhibits growth and lymphangiogenesis in breast cancer

Yaning Chen, Chenfang Zhu, Zhiyou Peng, Yalei Dai, Yan Gu

Pages: 1778-1784 Published online on: 10 August 2012

Frequent silencing of protocadherin 8 by promoter methylation, a candidate tumor suppressor for human gastric cancer

Danjie Zhang, Wei Zhao, Xinhua Liao, Tieqiang Bi, Haijun Li, Xiangming Che

Pages: 1785-1791 Published online on: 30 August 2012

Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma

Myung-Ha Song, Kyung-Un Choi, Dong-Hoon Shin, Chang-Hun Lee, Sang-Yull Lee

Pages: 1792-1798 Published online on: 30 August 2012

Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2

Chia-Ming Chang, Pei-Ying Chang, Ming-Gene Tu, Chi-Cheng Lu, Sheng-Chu Kuo, Sakae Amagaya, Chao-Ying Lee, Hui-Yu Jao, Michael Yuanchien Chen, Jai-Sing Yang

Pages: 1799-1807 Published online on: 24 August 2012

Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration

Chang-I Kung, Cheng-Yi Chen, Chih-Chang Yang, Cheng-Yu Lin, Tien-Hua Chen, Hwai-Shi Wang

Pages: 1808-1814 Published online on: 24 August 2012

Direct serum and tissue assay for EGFR mutation in non-small cell lung cancer by high-resolution melting analysis

Chengjin Hu, Xiaolei Liu, Yingjian Chen, Xiaoming Sun, Yanwen Gong, Ming Geng, Liquan Bi

Pages: 1815-1821 Published online on: 23 August 2012

In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy

Koji Tanaka, Masato Okigami, Yuji Toiyama, Yuki Morimoto, Kohei Matsushita, Mikio Kawamura, Kiyoshi Hashimoto, Susumu Saigusa, Yoshinaga Okugawa, Yasuhiro Inoue, Keiichi Uchida, Toshimitsu Araki, Yasuhiko Mohri, Akira Mizoguchi, Masato Kusunoki

Pages: 1822-1830 Published online on: 23 August 2012

miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells

Shuai Huang, Wei Guo, Yubo Tang, Dong Ren, Xuenong Zou, Xinsheng Peng

Pages: 1831-1837 Published online on: 04 September 2012

Changes in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumors

Dorota Zurawa-Janicka, Jarosław Kobiela, Natalia Galczynska, Tomasz Stefaniak, Barbara Lipinska, Andrzej Lachinski, Joanna Skorko-Glonek, Joanna Narkiewicz, Monika Proczko-Markuszewska, Zbigniew Sledzinski

Pages: 1838-1844 Published online on: 23 August 2012

Proteomic differential display identifies upregulated vinculin as a possible biomarker of pancreatic cancer

Yufeng Wang, Yasuhiro Kuramitsu, Tomio Ueno, Nobuaki Suzuki, Shigefumi Yoshino, Norio Iizuka, Xiulian Zhang, Junko Akada, Masaaki Oka, Kazuyuki Nakamura

Pages: 1845-1850 Published online on: 30 August 2012

Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways

Nicole A. Doudican, Shih Ya Wen, Amitabha Mazumder, Seth J. Orlow

Pages: 1851-1858 Published online on: 22 August 2012

Polymorphisms in base excision repair genes and thyroid cancer risk

Luís S. Santos, Sandra C. Branco, Susana N. Silva, Ana Paula Azevedo, Octávia M. Gil, Isabel Manita, Teresa C. Ferreira, Edward Limbert, José Rueff, Jorge F. Gaspar

Pages: 1859-1868 Published online on: 22 August 2012

Granulocyte colony-stimulating factor potentiates differentiation induction by all-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A

Noriyoshi Iriyama, Bo Yuan, Yoshihiro Hatta, Akira Horikoshi, Yuta Yoshino, Hiroo Toyoda, Shin Aizawa, Jin Takeuchi

Pages: 1875-1882 Published online on: 31 August 2012

Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

Chao-Ying Lee, Yung-Shin Chien, Tai-Hui Chiu, Wen-Wen Huang, Chi-Cheng Lu, Jo-Hua Chiang, Jai-Sing Yang

Pages: 1883-1888 Published online on: 30 August 2012

Yes is a central mediator of cell growth in malignant mesothelioma cells

Ayami Sato, Miki Sekine, Nantiga Virgona, Masako Ota, Tomohiro Yano

Pages: 1889-1893 Published online on: 03 September 2012

Radiosensitizing effects of arsenic trioxide on MCF-7 human breast cancer cells exposed to 89strontium chloride

Hengchao Liu, Xinquan Tao, Fang Ma, Jun Qiu, Cuiping Wu, Mingming Wang

Pages: 1894-1902 Published online on: 22 August 2012

17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion

Katarzyna Miekus, Jacek Kijowski, Małgorzata Sekuła, Marcin Majka

Pages: 1903-1903 Published online on: 27 August 2012

Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2

Yong-Sik Kim, Eun-Ae Kim, Kyu-Gun Park, Sung-Jun Lee, Mi-Sun Kim, Ho-Yong Sohn, Tae-Jin Lee

Pages: 1910-1916 Published online on: 09 August 2012

Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells

Cheng Zhang, Guang-Rong Gao, Chen-Guang Lv, Boa-Lei Zhang, Zhi-Li Zhang, Xue-Feng Zhang

Pages: 1917-1923 Published online on: 30 August 2012

TRIAD1 is negatively regulated by the MDM2 E3 ligase

Seunghee Bae, Jin Hyuk Jung, In-Sook An, Ok-Yeoun Kim, Myoung Joo Lee, Jae Ho Lee, In-Chul Park, Su-Jae Lee, Sungkwan An

Pages: 1924-1928 Published online on: 31 August 2012
Journal Cover

November 2012
Volume 28 Issue 5

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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