Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: Report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology

Yamaguchi,Rin; Tsuchiya,Shin-Ιchi; Koshikawa,Takashi; Ishihara,Akinori; Masuda,Shinobu; Maeda,Ichiro; Takimoto,Masafumi; Kawamoto,Masashi; Satoh,Haruaki; Narita,Michihiko; Itoh,Hitoshi; Kitamura,Takashi; Tsuda,Yoshiko; Ogane,Naoki; Abe,Eiji; Ikeda,Katsuhide; Nakamura,Takeshi; Kamaguchi,Harumi; Tokoro,Yoshiro

doi:10.3892/or.2012.2014

November 2012 Volume 28 Issue 5

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November 2012 Volume 28 Issue 5

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Article

Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: Report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology

Authors:
- Rin Yamaguchi
- Shin-Ιchi Tsuchiya
- Takashi Koshikawa
- Akinori Ishihara
- Shinobu Masuda
- Ichiro Maeda
- Masafumi Takimoto
- Masashi Kawamoto
- Haruaki Satoh
- Michihiko Narita
- Hitoshi Itoh
- Takashi Kitamura
- Yoshiko Tsuda
- Naoki Ogane
- Eiji Abe
- Katsuhide Ikeda
- Takeshi Nakamura
- Harumi Kamaguchi
- Yoshiro Tokoro
View Affiliations / Copyright

Affiliations: Department of Pathology, Kurume University School of Medicine/Kurume University Medical Center, Kurume, Japan, Department of Diagnostic Pathology, Nippon Medical School Hospital, Tokyo, Japan, Department of Pathology, Aichi Prefectural University, School of Nursing and Health, Aichi, Japan, Department of Clinical Pathology, Matsusaka Chuo General Hospital, Mie, Japan, Department of Pathology, Nihon University School of Medicine, Tokyo, Japan, Department of Pathology, St. Marianna University School of Medicine, Kanagawa, Japan, Department of Pathology, Showa University School of Medicine, Tokyo, Japan, Department of Clinical Pathology, University Hospital, Mizonokuchi, Teikyo University School of Medicine, Kanagawa, Japan, Department of Clinical Pathology, Toyota Kosei Hospital, Aichi, Japan, Division of Diagnostic Pathology, Tokai University Hospital, Kanagawa, Japan, Department of Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan, Laboratory for Pathology and Cytology, Kanagawa Cancer Center Hospital, Kanagawa, Japan, Department of Clinical Laboratory, Kitakyushu Municipal Medical Center, Fukuoka, Japan, Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan, Department of Pathology, Yokohama Minami Kyousai Hospital, Kanagawa, Japan, Department of Pathology and Molecular Diagnosis, Aichi Cancer Center, Aichi, Japan
Pages: 1606-1612
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Published online on: September 3, 2012

https://doi.org/10.3892/or.2012.2014
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Abstract

The Working Group of the Japanese Society of Clinical Cytology was assembled to assess the current status of breast cytology in Japan by conducting a large-scale survey regarding the accuracy of fine-needle aspiration biopsy (FNAB) in Japan. We collected data and investigated the status of breast cytological diagnosis at 12 different cooperating facilities in Japan, and re-evaluated their false-negative and false-positive cases. Among 30,535 individuals who underwent a breast cytological examination, analyses were conducted on 10,890 individuals (35.7%) in whom cytological diagnoses were confirmed by histology. Among these patients, the cytological diagnosis had an inadequate rate of 17.7%, an indeterminate rate of 7.8%, a positive predictive value of ‘malignancy suspected’ cells of 92.4%, an absolute sensitivity of 76.7%, a complete sensitivity of 96.7%, a specificity of 84.3%, a positive predictive value of ‘malignant’ cells of 99.5%, a false-negative value of 3.31%, a false-positive value of 0.25% and an accuracy rate of 88.0%. Subsequently, 297 false-negative and 23 false-positive cases were re-evaluated and several factors were characterized (i.e. histological type, tumor size and misread points). This survey collected data from a large number of cases for breast FNAB. Based on our survey, the accuracy of FNAB in Japan was relatively high compared with the goal of assessment of diagnostic accuracy. However, there were some false-negative and false-positive cases. Improvements in accuracy resulting from the learning points in the present study will lead to more useful and reliable diagnostic tools in clinical practice.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnostic accuracy of fine-needle aspiration cytology of the breast in Japan: Report from the Working Group on the Accuracy of Breast Fine-Needle Aspiration Cytology of the Japanese Society of Clinical Cytology

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