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December 2012 Volume 28 Issue 6

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Review

hTERT-based therapy: A universal anticancer approach (Review)

  • Authors:
    • Mu-Han Lü
    • Zhong-Li Liao
    • Xiao-Yan Zhao
    • Ya-Han Fan
    • Xian-Long Lin
    • Dian-Chun Fang
    • Hong Guo
    • Shi-Ming Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
  • Pages: 1945-1952
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    Published online on: September 17, 2012
       https://doi.org/10.3892/or.2012.2036
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Abstract

Human telomerase reverse transcriptase (hTERT) has been identified as a major protein involved in aberrant cell proliferation, immortalization, metastasis and stemness maintenance in a majority of tumors, yet it has little or no expression in normal somatic cells. During the past few years, the development of hTERT-based therapies such as immunotherapy, suicide gene therapy and small-molecule interfering therapy have become critical and specific for eradicating all types of cancer. Here, current knowledge regarding hTERT and its involvement in various cancers and its role as a target of cancer therapies are reviewed. Additionally, hurdles to new cancer therapy development and new therapeutic opportunities are described, along with areas that require further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Lü M, Liao Z, Zhao X, Fan Y, Lin X, Fang D, Guo H and Yang S: hTERT-based therapy: A universal anticancer approach (Review). Oncol Rep 28: 1945-1952, 2012.
APA
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D. ... Yang, S. (2012). hTERT-based therapy: A universal anticancer approach (Review). Oncology Reports, 28, 1945-1952. https://doi.org/10.3892/or.2012.2036
MLA
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D., Guo, H., Yang, S."hTERT-based therapy: A universal anticancer approach (Review)". Oncology Reports 28.6 (2012): 1945-1952.
Chicago
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D., Guo, H., Yang, S."hTERT-based therapy: A universal anticancer approach (Review)". Oncology Reports 28, no. 6 (2012): 1945-1952. https://doi.org/10.3892/or.2012.2036
Copy and paste a formatted citation
x
Spandidos Publications style
Lü M, Liao Z, Zhao X, Fan Y, Lin X, Fang D, Guo H and Yang S: hTERT-based therapy: A universal anticancer approach (Review). Oncol Rep 28: 1945-1952, 2012.
APA
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D. ... Yang, S. (2012). hTERT-based therapy: A universal anticancer approach (Review). Oncology Reports, 28, 1945-1952. https://doi.org/10.3892/or.2012.2036
MLA
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D., Guo, H., Yang, S."hTERT-based therapy: A universal anticancer approach (Review)". Oncology Reports 28.6 (2012): 1945-1952.
Chicago
Lü, M., Liao, Z., Zhao, X., Fan, Y., Lin, X., Fang, D., Guo, H., Yang, S."hTERT-based therapy: A universal anticancer approach (Review)". Oncology Reports 28, no. 6 (2012): 1945-1952. https://doi.org/10.3892/or.2012.2036
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