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Article

Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5

Corrigendum in: /10.3892/or.2022.8311
  • Authors:
    • Wei Xiao
    • Shumin Zhou
    • Hua Xu
    • Heng Li
    • Guoqing He
    • Yingle Liu
    • Yipeng Qi
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Hubei, Wuhan, P.R. China, Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan, P.R. China
  • Pages: 109-116
    |
    Published online on: October 4, 2012
       https://doi.org/10.3892/or.2012.2069
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Abstract

Cervical cancer is a common malignancy in women worldwide, and the occurrence of invasion and metastasis is the major cause for most cancer-related deaths. Epithelial-mesenchymal transition (EMT) has been implicated in the metastasis of primary tumors and provides molecular mechanisms for cervical cancer metastasis. We previously reported that Nogo-B mediates cell motility by binding Fibulin-5. Herein, we show that the increased expression of Nogo-B is correlated with the degree of cervical cancer metastasis. In HeLa cervical cancer cells, overexpression of Nogo-B induces the EMT and promotes cell migration and invasion, while inhibiting cell adhesion. Furthermore, we found that Nogo-B accumulates and co-localizes with Fibulin-5 in pseudopods, and the downstream effects of overexpression of Nogo-B on cell motility could be partially abolished by RNA interference against Fibulin-5. These results suggest that Nogo-B functions as an inducer of cervical cancer metastasis and that this effect is mediated, at least in part, through Fibulin-5.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao W, Zhou S, Xu H, Li H, He G, Liu Y and Qi Y: Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311. Oncol Rep 29: 109-116, 2013.
APA
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., & Qi, Y. (2013). Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311. Oncology Reports, 29, 109-116. https://doi.org/10.3892/or.2012.2069
MLA
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., Qi, Y."Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311". Oncology Reports 29.1 (2013): 109-116.
Chicago
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., Qi, Y."Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311". Oncology Reports 29, no. 1 (2013): 109-116. https://doi.org/10.3892/or.2012.2069
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao W, Zhou S, Xu H, Li H, He G, Liu Y and Qi Y: Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311. Oncol Rep 29: 109-116, 2013.
APA
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., & Qi, Y. (2013). Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311. Oncology Reports, 29, 109-116. https://doi.org/10.3892/or.2012.2069
MLA
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., Qi, Y."Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311". Oncology Reports 29.1 (2013): 109-116.
Chicago
Xiao, W., Zhou, S., Xu, H., Li, H., He, G., Liu, Y., Qi, Y."Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5 Corrigendum in /10.3892/or.2022.8311". Oncology Reports 29, no. 1 (2013): 109-116. https://doi.org/10.3892/or.2012.2069
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