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Article

Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells

  • Authors:
    • Tao Huang
    • Zhijun Chen
    • Liping Fang
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    Affiliations: Department of Orthopedic Surgery, Affiliated Hospital of Xi'an Medical College, Xi'an 710077, P.R. China, Department of Respiratory Medicine, Jinling hospital of Nanjing, Nanjing 210001, P.R. China
  • Pages: 117-124
    |
    Published online on: October 16, 2012
       https://doi.org/10.3892/or.2012.2080
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Abstract

Epithelial-mesenchymal transition (EMT) is considered a critical event in cancer cell invasion and metastasis. Emerging evidence has shown that curcumin may prevent or delay the progression of cancer, an effect that may be partially due to its ability to disrupt EMT, yet this has not yet been demonstrated. In this study, we used lipopolysaccharide (LPS) to trigger EMT in MCF-7 and MDA-MB-231 breast cancer cell lines and showed that curcumin inhibited LPS-induced morphological changes, decreased the expression of LPS-induced markers of EMT such as vimentin, and increased the expression of E-cadherin, resulting in the inhibition of in vitro cell motility and invasiveness. We discovered that these actions were mediated through the inactivation of NF-κB-Snail signaling pathways. Our results indicate that curcumin plays an important role in the inhibition of LPS-induced EMT in breast cancer cells through the downregulation of NF-κB-Snail activity. These data provide a new perspective of the anti-invasive mechanism of curcumin, indicating that the effect is partly due to its ability to attack the EMT process.
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Copy and paste a formatted citation
Spandidos Publications style
Huang T, Chen Z and Fang L: Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncol Rep 29: 117-124, 2013.
APA
Huang, T., Chen, Z., & Fang, L. (2013). Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncology Reports, 29, 117-124. https://doi.org/10.3892/or.2012.2080
MLA
Huang, T., Chen, Z., Fang, L."Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells". Oncology Reports 29.1 (2013): 117-124.
Chicago
Huang, T., Chen, Z., Fang, L."Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells". Oncology Reports 29, no. 1 (2013): 117-124. https://doi.org/10.3892/or.2012.2080
Copy and paste a formatted citation
x
Spandidos Publications style
Huang T, Chen Z and Fang L: Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncol Rep 29: 117-124, 2013.
APA
Huang, T., Chen, Z., & Fang, L. (2013). Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells. Oncology Reports, 29, 117-124. https://doi.org/10.3892/or.2012.2080
MLA
Huang, T., Chen, Z., Fang, L."Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells". Oncology Reports 29.1 (2013): 117-124.
Chicago
Huang, T., Chen, Z., Fang, L."Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells". Oncology Reports 29, no. 1 (2013): 117-124. https://doi.org/10.3892/or.2012.2080
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