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Article

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

  • Authors:
    • Yuho Maki
    • Junichi Soh
    • Kouichi Ichimura
    • Kazuhiko Shien
    • Masashi Furukawa
    • Takayuki Muraoka
    • Norimitsu Tanaka
    • Tsuyoshi Ueno
    • Hiromasa Yamamoto
    • Hiroaki Asano
    • Kazunori Tsukuda
    • Shinichi Toyooka
    • Shinichiro Miyoshi
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan, Department of Pathology, Okayama University Hospital, Okayama, Japan
  • Pages: 133-140
    |
    Published online on: October 17, 2012
       https://doi.org/10.3892/or.2012.2087
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Abstract

High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma was proposed. In this study, we investigated the clinicopathological impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma classified according to the IASLC/ATS/ERS classification. One hundred and five patients with completely resected stage IA lung adenocarcinoma were retrospectively classified into two groups, a ʻnon-invasive typeʼ (n=31) or an ʻinvasive typeʼ (n=74), based on the IASLC/ATS/ERS classification. GLUT1 and Ki-67 expression status was evaluated using immunohistochemistry. The epidermal growth factor receptor (EGFR) and KRAS mutation status was determined using PCR-based assays. Positive GLUT1 and Ki-67 expression and EGFR and KRAS mutations were detected in 28 (27%), 33 (31%), 51 (49%) and 5 (8%) cases, respectively. Positive GLUT1 expression was significantly associated with a wild-type EGFR and mutant KRAS status. A multivariate analysis revealed that positive GLUT1 expression was independently associated with the ʻinvasive typeʼ. In multivariate analyses for overall survival (OS) and disease-free survival (DFS), positive Ki-67 and GLUT1 expression was the only independent factor for a poor OS (P=0.012) and DFS (P=0.040), respectively. In addition, when stratified according to the GLUT1 and Ki-67 status, double-positive cases had the poorest DFS and OS times, compared with the other categories. Positive GLUT1 expression is associated with the invasive character of early-stage lung adenocarcinoma and with early disease relapse. Our results strongly suggest that GLUT1 and Ki-67 play important roles in acquiring biological malignant potential in early-stage lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Maki Y, Soh J, Ichimura K, Shien K, Furukawa M, Muraoka T, Tanaka N, Ueno T, Yamamoto H, Asano H, Asano H, et al: Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification. Oncol Rep 29: 133-140, 2013.
APA
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T. ... Miyoshi, S. (2013). Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification. Oncology Reports, 29, 133-140. https://doi.org/10.3892/or.2012.2087
MLA
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T., Tanaka, N., Ueno, T., Yamamoto, H., Asano, H., Tsukuda, K., Toyooka, S., Miyoshi, S."Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification". Oncology Reports 29.1 (2013): 133-140.
Chicago
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T., Tanaka, N., Ueno, T., Yamamoto, H., Asano, H., Tsukuda, K., Toyooka, S., Miyoshi, S."Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification". Oncology Reports 29, no. 1 (2013): 133-140. https://doi.org/10.3892/or.2012.2087
Copy and paste a formatted citation
x
Spandidos Publications style
Maki Y, Soh J, Ichimura K, Shien K, Furukawa M, Muraoka T, Tanaka N, Ueno T, Yamamoto H, Asano H, Asano H, et al: Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification. Oncol Rep 29: 133-140, 2013.
APA
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T. ... Miyoshi, S. (2013). Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification. Oncology Reports, 29, 133-140. https://doi.org/10.3892/or.2012.2087
MLA
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T., Tanaka, N., Ueno, T., Yamamoto, H., Asano, H., Tsukuda, K., Toyooka, S., Miyoshi, S."Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification". Oncology Reports 29.1 (2013): 133-140.
Chicago
Maki, Y., Soh, J., Ichimura, K., Shien, K., Furukawa, M., Muraoka, T., Tanaka, N., Ueno, T., Yamamoto, H., Asano, H., Tsukuda, K., Toyooka, S., Miyoshi, S."Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification". Oncology Reports 29, no. 1 (2013): 133-140. https://doi.org/10.3892/or.2012.2087
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