Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March 2013 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March 2013 Volume 29 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2

  • Authors:
    • Alexander Shimabukuro-Vornhagen
    • Andreas Draube
    • Tanja Liebig
    • Alexey Popov
    • Achim Rothe
    • Michael von Bergwelt-Baildon
  • View Affiliations / Copyright

    Affiliations: Cologne Interventional Immunology (CII), Department I of Internal Medicine, University Hospital of Cologne, D-50924 Cologne, Germany
  • Pages: 1061-1065
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/or.2012.2215
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor vaccination represents a promising immuno­therapeutic strategy in cancer. However, the inherent ability of many tumors to evade immune responses by suppression of immune cell function represents a major barrier. Prostaglandin E2 (PGE2) has been shown to be a critical tumor-derived immunosuppressive factor. It affects a broad range of immune cells including T cells, macrophages and dendritic cells (DCs). CD40-activated B cells are being studied as a potential alternative to DCs as antigen-presenting cells for immunotherapy. So far, it is not known whether PGE2 affects their antigen presenting capacity. We, therefore, investigated the influence of PGE2 on the phenotype, migratory potential and antigen-presenting function of CD40-activated human B cells. Here, we demonstrate that the immunostimulatory properties of CD40-activated B cells are not affected by PGE2. These results support the use of CD40-activated B cells as cellular adjuvants, especially in settings where PGE2 is present in the tumor microenvironment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Rosenberg S, Yang J and Restifo N: Cancer immunotherapy: moving beyond current vaccines. Nat Med. 10:909–915. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Finn OJ: Cancer immunology. N Engl J Med. 358:2704–2715. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Kantoff PW, Higano CS, Shore ND, et al: Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 363:411–422. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Palucka K, Ueno H and Banchereau J: Recent developments in cancer vaccines. J Immunol. 186:1325–1331. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Copier J, Dalgleish AG, Britten CM, et al: Improving the efficacy of cancer immunotherapy. Eur J Cancer. 45:1424–1431. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Zou W: Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol. 6:295–307. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kalinski P: Regulation of immune responses by prostaglandin E2. J Immunol. 188:21–28. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Matsuoka T and Narumiya S: The roles of prostanoids in infection and sickness behaviors. J Infect Chemother. 14:270–278. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Sheng KC, Wright MD and Apostolopoulos V: Inflammatory mediators hold the key to dendritic cell suppression and tumor progression. Curr Med Chem. 18:5507–5518. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sombroek CC, Stam AG, Masterson AJ, et al: Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J Immunol. 168:4333–4343. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Kolenko V, Rayman P, Roy B, et al: Downregulation of JAK3 protein levels in T lymphocytes by prostaglandin E2 and other cyclic adenosine monophosphate-elevating agents: impact on interleukin-2 receptor signaling pathway. Blood. 93:2308–2318. 1999.

12 

Walker W and Rotondo D: Prostaglandin E2 is a potent regulator of interleukin-12- and interleukin-18-induced natural killer cell interferon-γ synthesis. Immunology. 111:298–305. 2004.

13 

Obermajer N, Muthuswamy R, Lesnock J, et al: Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells. Blood. 118:5498–5505. 2011.PubMed/NCBI

14 

Krishnamoorthy S and Honn KV: Eicosanoids in tumor progression and metastasis. Subcell Biochem. 49:145–168. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Haas AR, Sun J, Vachani A, et al: Cyclooxygenase-2 inhibition augments the efficacy of a cancer vaccine. Clin Cancer Res. 12:214–222. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Luft T, Jefford M, Luetjens P, et al: Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood. 100:1362–1372. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Scandella E, Men Y, Gillessen S, et al: Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood. 100:1354–1361. 2002.

18 

Braun D, Longman RS and Albert ML: A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation. Blood. 106:2375–2381. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Von Bergwelt-Baildon MS, Popov A, Saric T, et al: CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition. Blood. 108:228–237. 2006.PubMed/NCBI

20 

Muthuswamy R, Mueller-Berghaus J, Haberkorn U, et al: PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells. Blood. 116:1454–1459. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Martin F and Chan AC: B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol. 24:467–496. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Shimabukuro-Vornhagen A, Hallek MJ, Storb RF, et al: The role of B cells in the pathogenesis of graft-versus-host disease. Blood. 114:4919–4927. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Mason NJ, Coughlin CM, Overley B, et al: RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma. Gene Ther. 15:955–965. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Sorenmo KU, Krick E, Coughlin CM, et al: CD40-activated B cell cancer vaccine improves second clinical remission and survival in privately owned dogs with non-Hodgkin’s lymphoma. PLoS One. 6:e241672011.PubMed/NCBI

25 

Von Bergwelt-Baildon M, Shimabukuro-Vornhagen A, Popov A, et al: CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants. Blood. 107:2786–2789. 2006.PubMed/NCBI

26 

Wiesner M, Zentz C, Mayr C, et al: Conditional immortalization of human B cells by CD40 ligation. PLoS One. 3:e14642008. View Article : Google Scholar : PubMed/NCBI

27 

Kondo E, Gryschok L, Klein-Gonzalez N, et al: CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential. Clin Exp Immunol. 155:249–256. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Liebig TM, Fiedler A, Zoghi S, et al: Generation of human CD40-activated B cells. J Vis Exp. pii. 13732009.PubMed/NCBI

29 

Popov A, Driesen J, Abdullah Z, et al: Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanisms. J Immunol. 181:4976–4988. 2008.PubMed/NCBI

30 

Chemnitz JM, Driesen J, Classen S, et al: Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin’s lymphoma. Cancer Res. 66:1114–1122. 2006.

31 

Bekeredjian-Ding I, Schafer M, Hartmann E, et al: Tumour-derived prostaglandin E2 and transforming growth factor-β synergize to inhibit plasmacytoid dendritic cell-derived interferon-α. Immunology. 128:439–450. 2009.

32 

Herfs M, Herman L, Hubert P, et al: High expression of PGE2 enzymatic pathways in cervical (pre)neoplastic lesions and functional consequences for antigen-presenting cells. Cancer Immunol Immunother. 58:603–614. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Muthuswamy R, Urban J, Lee JJ, et al: Ability of mature dendritic cells to interact with regulatory T cells is imprinted during maturation. Cancer Res. 68:5972–5978. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Krause P, Singer E, Darley PI, et al: Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO. J Leukoc Biol. 82:1106–1114. 2007.

35 

Wobser M, Voigt H, Houben R, et al: Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression. Cancer Immunol Immunother. 56:1017–1024. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Forster R, Schubel A, Breitfeld D, et al: CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 99:23–33. 1999. View Article : Google Scholar : PubMed/NCBI

37 

Ohl L, Mohaupt M, Czeloth N, et al: CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity. 21:279–288. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Kabashima K, Shiraishi N, Sugita K, et al: CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol. 171:1249–1257. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Schultze JL, Grabbe S and von Bergwelt-Baildon MS: DCs and CD40-activated B cells: current and future avenues to cellular cancer immunotherapy. Trends Immunol. 25:659–664. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Kim SK, Nguyen Pham TN, Nguyen Hoang TM, et al: Induction of myeloma-specific cytotoxic T lymphocytes ex vivo by CD40-activated B cells loaded with myeloma tumor antigens. Ann Hematol. 88:1113–1123. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Harizi H, Grosset C and Gualde N: Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes. J Leukoc Biol. 73:756–763. 2003.

42 

Legler DF, Krause P, Scandella E, et al: Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors. J Immunol. 176:966–973. 2006.PubMed/NCBI

43 

Fedyk ER and Phipps RP: Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. Proc Natl Acad Sci USA. 93:10978–10983. 1996.PubMed/NCBI

44 

Lee H, Trott JS, Haque S, et al: A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells. J Immunol. 185:5300–5314. 2010.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shimabukuro-Vornhagen A, Draube A, Liebig T, Popov A, Rothe A and von Bergwelt-Baildon M: The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2. Oncol Rep 29: 1061-1065, 2013.
APA
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., & von Bergwelt-Baildon, M. (2013). The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2. Oncology Reports, 29, 1061-1065. https://doi.org/10.3892/or.2012.2215
MLA
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., von Bergwelt-Baildon, M."The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2". Oncology Reports 29.3 (2013): 1061-1065.
Chicago
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., von Bergwelt-Baildon, M."The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2". Oncology Reports 29, no. 3 (2013): 1061-1065. https://doi.org/10.3892/or.2012.2215
Copy and paste a formatted citation
x
Spandidos Publications style
Shimabukuro-Vornhagen A, Draube A, Liebig T, Popov A, Rothe A and von Bergwelt-Baildon M: The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2. Oncol Rep 29: 1061-1065, 2013.
APA
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., & von Bergwelt-Baildon, M. (2013). The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2. Oncology Reports, 29, 1061-1065. https://doi.org/10.3892/or.2012.2215
MLA
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., von Bergwelt-Baildon, M."The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2". Oncology Reports 29.3 (2013): 1061-1065.
Chicago
Shimabukuro-Vornhagen, A., Draube, A., Liebig, T., Popov, A., Rothe, A., von Bergwelt-Baildon, M."The properties of human CD40-activated B cells as antigen-presenting cells are not affected by PGE2". Oncology Reports 29, no. 3 (2013): 1061-1065. https://doi.org/10.3892/or.2012.2215
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team