Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression

  • Authors:
    • Jeong-Mi Kim
    • Eun-Mi Noh
    • Kang-Beom Kwon
    • Jong-Suk Kim
    • Yong-Ouk You
    • Jin-Ki Hwang
    • Bo-Mi Hwang
    • Min Seuk Kim
    • Seung-Jin Lee
    • Sung-Hoo Jung
    • Hyun-Jo Youn
    • Eun-Yong Chung
    • Young-Rae Lee
  • View Affiliations

  • Published online on: December 28, 2012     https://doi.org/10.3892/or.2012.2218
  • Pages: 1231-1237
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Abstract

Cell invasion is required for neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in the process of cancer cell invasion. Sulfuretin is one of the major flavonoids isolated from Rhus verniciflua. Sulfuretin has been used to reduce oxidative stress, platelet aggregation, the inflammatory response and mutagenesis. However, the effect of sulfuretin on breast cancer metastasis is unknown. In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Sulfuretin inhibited TPA-induced transcriptional activation of nuclear factor-κB (NF-κB). We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-κB pathway. Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness.
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March 2013
Volume 29 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim J, Noh E, Kwon K, Kim J, You Y, Hwang J, Hwang B, Kim M, Lee S, Jung S, Jung S, et al: Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncol Rep 29: 1231-1237, 2013
APA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J. ... Lee, Y. (2013). Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncology Reports, 29, 1231-1237. https://doi.org/10.3892/or.2012.2218
MLA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29.3 (2013): 1231-1237.
Chicago
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29, no. 3 (2013): 1231-1237. https://doi.org/10.3892/or.2012.2218