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Article

Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression

  • Authors:
    • Jeong-Mi Kim
    • Eun-Mi Noh
    • Kang-Beom Kwon
    • Jong-Suk Kim
    • Yong-Ouk You
    • Jin-Ki Hwang
    • Bo-Mi Hwang
    • Min Seuk Kim
    • Seung-Jin Lee
    • Sung-Hoo Jung
    • Hyun-Jo Youn
    • Eun-Yong Chung
    • Young-Rae Lee
  • View Affiliations / Copyright

    Affiliations: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan 570-749, Republic of Korea, Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju 560-182, Republic of Korea, Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan 570-749, Republic of Korea, Laboratory of Oral Physiology, College of Dentistry, Wonkwang University, Iksan 570-749, Republic of Korea, Department of Pharmacy, College of Pharmacy, Ewha Womans University, Seoul 120-808, Republic of Korea, Division of Breast, Thyroid Surgery, Department of Surgery, Chonbuk National University Medical School, Jeonju 560-756, Republic of Korea, Department of Anesthesiology and Pain Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Bucheon 420-717, Republic of Korea
  • Pages: 1231-1237
    |
    Published online on: December 28, 2012
       https://doi.org/10.3892/or.2012.2218
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Abstract

Cell invasion is required for neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in the process of cancer cell invasion. Sulfuretin is one of the major flavonoids isolated from Rhus verniciflua. Sulfuretin has been used to reduce oxidative stress, platelet aggregation, the inflammatory response and mutagenesis. However, the effect of sulfuretin on breast cancer metastasis is unknown. In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Sulfuretin inhibited TPA-induced transcriptional activation of nuclear factor-κB (NF-κB). We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-κB pathway. Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness.
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Copy and paste a formatted citation
Spandidos Publications style
Kim J, Noh E, Kwon K, Kim J, You Y, Hwang J, Hwang B, Kim M, Lee S, Jung S, Jung S, et al: Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncol Rep 29: 1231-1237, 2013.
APA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J. ... Lee, Y. (2013). Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncology Reports, 29, 1231-1237. https://doi.org/10.3892/or.2012.2218
MLA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29.3 (2013): 1231-1237.
Chicago
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29, no. 3 (2013): 1231-1237. https://doi.org/10.3892/or.2012.2218
Copy and paste a formatted citation
x
Spandidos Publications style
Kim J, Noh E, Kwon K, Kim J, You Y, Hwang J, Hwang B, Kim M, Lee S, Jung S, Jung S, et al: Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncol Rep 29: 1231-1237, 2013.
APA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J. ... Lee, Y. (2013). Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. Oncology Reports, 29, 1231-1237. https://doi.org/10.3892/or.2012.2218
MLA
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29.3 (2013): 1231-1237.
Chicago
Kim, J., Noh, E., Kwon, K., Kim, J., You, Y., Hwang, J., Hwang, B., Kim, M., Lee, S., Jung, S., Youn, H., Chung, E., Lee, Y."Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression". Oncology Reports 29, no. 3 (2013): 1231-1237. https://doi.org/10.3892/or.2012.2218
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