Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma

Ishibashi,Masahisa; Kogo,Ryunosuke; Shibata,Kohei; Sawada,Genta; Takahashi,Yusuke; Kurashige,Junji; Akiyoshi,Sayuri; Sasaki,Shin; Iwaya,Takeshi; Sudo,Tomoya; Sugimachi,Keishi; Mimori,Koshi; Wakabayashi,Go; Mori,Masaki

doi:10.3892/or.2012.2219

March 2013 Volume 29 Issue 3

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March 2013 Volume 29 Issue 3

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Article

Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma

Authors:
- Masahisa Ishibashi
- Ryunosuke Kogo
- Kohei Shibata
- Genta Sawada
- Yusuke Takahashi
- Junji Kurashige
- Sayuri Akiyoshi
- Shin Sasaki
- Takeshi Iwaya
- Tomoya Sudo
- Keishi Sugimachi
- Koshi Mimori
- Go Wakabayashi
- Masaki Mori
View Affiliations / Copyright

Affiliations: Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan, Omori Red Cross Hospital, Oota, Tokyo 143-8527, Japan, Department of Surgery, Iwate Medical University, Morioka, Iwate 020-8505, Japan, Department of Gastroenterological Surgery, Osaka University, Suita, Osaka 565-0871, Japan
Pages: 946-950
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Published online on: December 28, 2012

https://doi.org/10.3892/or.2012.2219
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Abstract

The functions of many long non-coding RNAs (ncRNAs) in human cancers have not yet been elucidated. The long ncRNA HOTAIR is expressed from the developmental HOXC locus located on chromosome 12q13.13. Previous reports have demonstrated that HOTAIR associates with chromatin modifications in cooperation with the Polycomb complex PRC2, and promotes breast and colorectal cancer metastasis. In this study, we examined the clinical significance of HOTAIR expression in patients with hepatocellular carcinoma (HCC). HOTAIR expression was detected in primary HCCs in 13 out of 64 patients. Patients with HOTAIR expression had significantly poorer prognoses and a larger primary tumor size than those without HOTAIR expression, similar to studies in breast and colorectal cancers. Moreover, introduction of human HOTAIR into liver cancer cells revealed that HOTAIR promoted more rapid proliferation compared to control cells. Thus, although the clinical significance of HOTAIR expression in HCC may not be as pronounced as that in breast and colorectal cancers, the current study demonstrates that HOTAIR expression is associated with HCC progression, warranting further studies.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma

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