PDCD4 functions as a suppressor for pT2a and pT2b stage gastric cancer

Guo,Peng-Tao; Yang,Dong; Sun,Zhe; Xu,Hui-Mian

doi:10.3892/or.2013.2232

PDCD4 functions as a suppressor for pT2a and pT2b stage gastric cancer

Authors:
- Peng-Tao Guo
- Dong Yang
- Zhe Sun
- Hui-Mian Xu
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Affiliations: Department of Surgical Oncology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: January 11, 2013 https://doi.org/10.3892/or.2013.2232
Pages: 1007-1012

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Abstract

Gastric cancer is one of the leading causes of cancer‑related mortality worldwide. Loss of programmed cell death 4 (PDCD4) expression has been detected in gastric cancer. However, the effects of PDCD4 on pT2 stage gastric cancer remain unclear. The aim of this study was to identify the relationship between PDCD4 expression and clinicopathological features of patients with pT2 stage gastric cancer. In the present study, 122 pT2 stage gastric cancer specimens were subclassified as pT2a and pT2b stage. The levels of PDCD4 mRNA and protein in gastric cancer tissues were lower compared to that in normal tissues as detected by real‑time PCR and western blot analysis, respectively. In addition, both PDCD4 mRNA and protein in pT2b stage gastric cancer were lower when compared to that in pT2a stage gastric cancer. Finally, we used immunohistochemistry to determine the protein expression and analyzed the relationship between PDCD4 expression and the clinicopathological features of pT2 stage gastric cancer patients. Cumulative survival rate of patients with PDCD4 expression was significantly higher compared to the patients without PDCD4 expression. PDCD4 expression in gastric cancer can be employed to indicate a favorable prognosis for the disease outcome.

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