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Article

Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients

  • Authors:
    • Anna Göthlin Eremo
    • Pia Wegman
    • Olle Stål
    • Bo Nordenskjöld
    • Tommy Fornander
    • Sten Wingren
  • View Affiliations / Copyright

    Affiliations: School of Health and Medical Sciences, Örebro University, SE-70182 Örebro, Sweden, Department of Clinical and Experimental Medicine, Division of Oncology, Faculty of Health Sciences, Linköping University, SE-58185 Linköping, Sweden, Department of Oncology, Karolinska University Hospital, Stockholm South General Hospital, SE-11883 Stockholm, Sweden
  • Pages: 1467-1474
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    Published online on: January 31, 2013
       https://doi.org/10.3892/or.2013.2261
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Abstract

Reduced or absent Wwox expression has recently been associated with tamoxifen resistance in breast cancer and has also been proposed as a candidate predictive marker for treatment. We aimed to investigate the correlation of Wwox expression with the outcome of tamoxifen treatment by examining tissues from 912 randomized breast cancer patients. Paraffin-embedded tissues from patient tumors were arranged on tissue microarray, and Wwox protein was stained using immunohistochemistry. After microscopic examination, the results were analyzed with Cox regression, Kaplan-Meier survival curves and the log-rank test. In the group of cases having a tumor absent for Wwox expression, there was no difference in recurrence-free survival between treated and untreated patients (P=0.81). For treated cases with a tumor expressing moderate or strong Wwox protein, recurrence-free survival was improved (P=0.001 and P=0.003, respectively). The test for interaction between Wwox and treatment response demonstrated a decreased risk of recurrence for treated patients with a moderate or strong Wwox expression (HR=0.31, 95% CI 0.10-0.98 and HR=0.28, 95% CI 0.08-0.97, respectively). Our results indicate that patients with high expression of Wwox may gain more benefit from treatment with tamoxifen.
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1 

Ring A and Dowsett M: Mechanisms of tamoxifen resistance. Endocr Relat Cancer. 11:643–658. 2004. View Article : Google Scholar

2 

Greenspan EM: Tamoxifen in early breast cancer. Lancet. 1:6551983. View Article : Google Scholar : PubMed/NCBI

3 

Rose C, Thorpe SM, Andersen KW, Pedersen BV, Mouridsen HT, Blichert-Toft M and Rasmussen BB: Beneficial effect of adjuvant tamoxifen therapy in primary breast cancer patients with high oestrogen receptor values. Lancet. 1:16–19. 1985. View Article : Google Scholar : PubMed/NCBI

4 

Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA and Greene GL: The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell. 95:927–937. 1998. View Article : Google Scholar

5 

Stewart HJ and Prescott R: Adjuvant tamoxifen therapy and receptor levels. Lancet. 1:5731985. View Article : Google Scholar : PubMed/NCBI

6 

Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H and Watson JE: WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci USA. 98:11417–11422. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, et al: Targeted deletion of Wwox reveals a tumor suppressor function. Proc Natl Acad Sci USA. 104:3949–3954. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA and Aldaz CM: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res. 60:2140–2145. 2000.PubMed/NCBI

9 

Nunez MI, Ludes-Meyers J, Abba MC, Kil H, Abbey NW, Page RE, Sahin A, Klein-Szanto AJ and Aldaz CM: Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status. Breast Cancer Res Treat. 89:99–105. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Płuciennik E, Kusińska R, Potemski P, Kubiak R, Kordek R and Bednarek AK: WWOX - the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis. Eur J Surg Oncol. 32:153–157. 2006.PubMed/NCBI

11 

Driouch K, Prydz H, Monese R, Johansen H, Lidereau R and Frengen E: Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors. Oncogene. 21:1832–1840. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Guler G, Uner A, Guler N, Han SY, Iliopoulos D, Hauck WW, McCue P and Huebner K: The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma. Cancer. 100:1605–1614. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Nunez MI, Ludes-Meyers J and Aldaz CM: WWOX protein expression in normal human tissues. J Mol Histol. 37:115–125. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ and Aldaz CM: WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 61:8068–8073. 2001.PubMed/NCBI

15 

Aqeilan RI, Kuroki T, Pekarsky Y, Albagha O, Trapasso F, Baffa R, Huebner K, Edmonds P and Croce CM: Loss of WWOX expression in gastric carcinoma. Clin Cancer Res. 10:3053–3058. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Baykara O, Demirkaya A, Kaynak K, Tanju S, Toker A and Buyru N: WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC). Tumour Biol. 31:315–320. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Bloomston M, Kneile J, Butterfield M, Dillhoff M, Muscarella P, Ellison EC, Melvin WS, Croce CM, Pichiorri F, Huebner, et al: Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Ann Surg Oncol. 16:2331–2338. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, et al: WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci USA. 102:15611–15616. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Finnis M, Dayan S, Hobson L, Chenevix-Trench G, Friend K, Ried K, Venter D, Woollatt E, Baker E and Richards RI: Common chromosomal fragile site FRA16D mutation in cancer cells. Hum Mol Genet. 14:1341–1349. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Iliopoulos D, Guler G, Han SY, Johnston D, Druck T, McCorkell KA, Palazzo J, McCue PA, Baffa R and Huebner K: Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene. 24:1625–1633. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY and Huebner K: Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression. Clin Cancer Res. 13:268–274. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Kuroki T, Yendamuri S, Trapasso F, Matsuyama A, Aqeilan RI, Alder H, Rattan S, Cesari R, Nolli ML, Williams NN, et al: The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Clin Cancer Res. 10:2459–2465. 2004. View Article : Google Scholar : PubMed/NCBI

23 

O’Keefe LV, Liu Y, Perkins A, Dayan S, Saint R and Richards RI: FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. Oncogene. 24:6590–6596. 2005.PubMed/NCBI

24 

Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC and Aldaz CM: Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 91:753–759. 2004.PubMed/NCBI

25 

Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM, Morrison CD, Klein RD and Huebner K: A role for the WWOX gene in prostate cancer. Cancer Res. 66:6477–6481. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Guler G, Uner A, Guler N, Han SY, Iliopoulos D, McCue P and Huebner K: Concordant loss of fragile gene expression early in breast cancer development. Pathol Int. 55:471–478. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Chang NS, Schultz L, Hsu LJ, Lewis J, Su M and Sze CI: 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo. Oncogene. 24:714–723. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Guler G, Himmetoglu C, Jimenez RE, Geyer SM, Wang WP, Costinean S, Pilarski RT, Morrison C, Suren D, Liu J, et al: Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features. Breast Cancer Res Treat. 129:421–432. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, et al: Functional association between Wwox tumor suppressor protein and p73, a p53 homolog. Proc Natl Acad Sci USA. 101:4401–4406. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Chang NS, Doherty J, Ensign A, Schultz L, Hsu LJ and Hong Q: WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem. 280:43100–43108. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Guler G, Iliopoulos D, Guler N, Himmetoglu C, Hayran M and Huebner K: Wwox and Ap2gamma expression levels predict tamoxifen response. Clin Cancer Res. 13:6115–6121. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Guler G, Huebner K, Himmetoglu C, Jimenez RE, Costinean S, Volinia S, Pilarski RT, Hayran M and Shapiro CL: Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer. Cancer. 115:899–908. 2009. View Article : Google Scholar

33 

Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, Sudol M and Croce CM: WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 65:6764–6772. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Aqeilan RI, Donati V, Gaudio E, Nicoloso MS, Sundvall M, Korhonen A, Lundin J, Isola J, Sudol M, Joensuu H, et al: Association of Wwox with ErbB4 in breast cancer. Cancer Res. 67:9330–9336. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Abdeen SK, Salah Z, Maly B, Smith Y, Tufail R, Abu-Odeh M, Zanesi N, Croce CM, Nawaz Z and Aqeilan RI: Wwox inactivation enhances mammary tumorigenesis. Oncogene. 30:3900–3906. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Rutqvist LE, Johansson H and Group SBCS: Long-term follow-up of the randomized Stockholm trial on adjuvant tamoxifen among postmenopausal patients with early stage breast cancer. Acta Oncol. 46:133–145. 2007. View Article : Google Scholar

37 

Wang X, Chao L, Ma G, Chen L, Zang Y and Sun J: The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype. J Cancer Res Clin Oncol. 137:271–278. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Fox EM, Andrade J and Shupnik MA: Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids. 74:622–627. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Yang Z, Barnes CJ and Kumar R: Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells. Clin Cancer Res. 10:3621–3628. 2004. View Article : Google Scholar

40 

Watanabe A, Hippo Y, Taniguchi H, Iwanari H, Yashiro M, Hirakawa K, Kodama T and Aburatani H: An opposing view on WWOX protein function as a tumor suppressor. Cancer Res. 63:8629–8633. 2003.PubMed/NCBI

41 

Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H and Huebner K: Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling. Mol Cancer Res. 5:957–965. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Belsches-Jablonski AP, Biscardi JS, Peavy DR, Tice DA, Romney DA and Parsons SJ: Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene. 20:1465–1475. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Morgan L, Gee J, Pumford S, Farrow L, Finlay P, Robertson J, Ellis I, Kawakatsu H, Nicholson R and Hiscox S: Elevated Src kinase activity attenuates Tamoxifen response in vitro and is associated with poor prognosis clinically. Cancer Biol Ther. 8:1550–1558. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Pellikainen J, Naukkarinen A, Ropponen K, Rummukainen J, Kataja V, Kellokoski J, Eskelinen M and Kosma VM: Expression of HER2 and its association with AP-2 in breast cancer. Eur J Cancer. 40:1485–1495. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Junttila TT, Sundvall M, Lundin M, Lundin J, Tanner M, Härkönen P, Joensuu H, Isola J and Elenius K: Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells. Cancer Res. 65:1384–1393. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Naresh A, Thor AD, Edgerton SM, Torkko KC, Kumar R and Jones FE: The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis. Cancer Res. 68:6387–6395. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Göthlin Eremo A, Wegman P, Stål O, Nordenskjöld B, Fornander T and Wingren S: Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients. Oncol Rep 29: 1467-1474, 2013.
APA
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., & Wingren, S. (2013). Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients. Oncology Reports, 29, 1467-1474. https://doi.org/10.3892/or.2013.2261
MLA
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., Wingren, S."Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients". Oncology Reports 29.4 (2013): 1467-1474.
Chicago
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., Wingren, S."Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients". Oncology Reports 29, no. 4 (2013): 1467-1474. https://doi.org/10.3892/or.2013.2261
Copy and paste a formatted citation
x
Spandidos Publications style
Göthlin Eremo A, Wegman P, Stål O, Nordenskjöld B, Fornander T and Wingren S: Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients. Oncol Rep 29: 1467-1474, 2013.
APA
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., & Wingren, S. (2013). Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients. Oncology Reports, 29, 1467-1474. https://doi.org/10.3892/or.2013.2261
MLA
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., Wingren, S."Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients". Oncology Reports 29.4 (2013): 1467-1474.
Chicago
Göthlin Eremo, A., Wegman, P., Stål, O., Nordenskjöld, B., Fornander, T., Wingren, S."Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients". Oncology Reports 29, no. 4 (2013): 1467-1474. https://doi.org/10.3892/or.2013.2261
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