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Article

Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation

  • Authors:
    • Yuwarat Porameesanaporn
    • Wanlaya Uthaisang-Tanechpongtamb
    • Faongchat Jarintanan
    • Suchada Jongrungruangchok
    • Benjamas Thanomsub Wongsatayanon
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Srinakharinwirot University, Bangkok 10110, Thailand, Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand, Faculty of Medical Technology, Rangsit University, Pathum Thani 12000, Thailand, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand, Department of Microbiology, Srinakharinwirot University, Bangkok 10110, Thailand
  • Pages: 1600-1608
    |
    Published online on: February 15, 2013
       https://doi.org/10.3892/or.2013.2288
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Abstract

Terrein, a fungal metabolite derived from Aspergillus terreus, has been shown to have a variety of biological activities in human cells including inhibition of melanogenesis, as well as anti-inflammatory, antioxidant and anticancer properties. In the present study, terrein was shown to have marked anticancer activity on HeLa human cervical carcinoma cells. Terrein exhibited inhibition of proliferation within the same ranges for other cancer cell types with an IC50 at 0.29 mM. The growth inhibition that induced cell death was via apoptosis mechanisms. Chromatin condensation was observed using the Hoechst 33342 stain, a DNA-specific dye. The increase of DNA fragmentation or the sub-G0 peak was also detected by flow cytometry. The signaling used by terrein to induce apoptosis was via the death-receptor and mitochondrial pathways; the cleavage of specific fluorogenic substrates by caspase-3, -8 and -9 activities are clearly demonstrated. The mitochondria were damaged as demonstrated by the decrease of the red/green ratio of the JC-1 staining and the increase of the Bax/Bcl-2 expression ratio. Further analysis of the upstream signaling by the quantitative real-time polymerase chain reaction showed that p53, p21 and ERK were upregulated which indicates the importance of their roles on terrein signaling. This study is the first to show that terrein has an effect on the anticancer properties in cervical cancer cells by inducing apoptosis through p53 and ERK regulation. Our data may help expand the function of the terrein compound and may also aid in the discovery of new anticancer agents.
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View References

1 

Jit M, Demarteau N, Elbasha E, Ginsberg G, Kim J, Praditsitthikorn N, Sinanovic E and Hutubessy R: Human papillomavirus vaccine introduction in low-income and middle-income countries: guidance on the use of cost-effectiveness models. BMC Med. 54:2–9. 2011.PubMed/NCBI

2 

Thomas GM: Improved treatment for cervical cancer-concurrent chemotherapy and radiotherapy. N Engl J Med. 340:1198–1200. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Ren G, Zhao YP, Yang L and Fu CX: Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer Lett. 262:190–200. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Park SJ, Wu CH, Gordon JD, Zhong X, Emami A and Safa AR: Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 279:51057–51067. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Wang S, Konorev EA, Kotamraju S, Joseph J, Kalivendi S and Kalyanaraman B: Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. J Biol Chem. 279:25535–25543. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Day TW, Wu CH and Safa AR: Etoposide induces protein kinase Cδ- and caspase-3 dependent apoptosis in neuroblastoma cancer cells. Mol Pharmacol. 76:632–640. 2009.

7 

Tanida S, Mizoshita T, Ozeki K, Tsukamoto H, Kamiya T, Kataoka H, Sakamuro D and Joh T: Mechanisms of cisplatin-induced apoptosis and of cisplatin sensitivity: potential of BIN1 to act as a potent predictor of cisplatin sensitivity in gastric cancer treatment. Int J Surg Oncol. 2012:8628792012.PubMed/NCBI

8 

Newman DJ and Cragg GM: Microbial antitumor drugs: natural products of microbial origin as anticancer agents. Curr Opin Investig Drugs. 10:1280–1296. 2009.PubMed/NCBI

9 

Raistrick H and Smith G: Studies in the biochemistry of micro-organisms: the metabolic products of Aspergillus terreus Thom. A new mould metabolic product-terrein. Biochem J. 29:606–611. 1935.PubMed/NCBI

10 

Demasi M, Felicio AL, Pacheco AO, Leite HG, Lima C and Andrade LH: Studies on terrein as a new class of proteasome inhibitors. J Braz Chem Soc. 21:299–305. 2010. View Article : Google Scholar

11 

Park SH, Kim DS, Kim WG, Ryoo IJ, Lee DH, Huh CH, Youn SW, Yoo ID and Park KC: Terrein: a new melanogenesis inhibitor and its mechanism. Cell Mol Life Sci. 61:2878–2885. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kim DS, Lee S, Lee HK, Park SH, Ryoo IJ, Yoo ID, Kwon SB, Baek KJ, Na JI and Park KC: The hypopigmentary action of KI-063 (a new tyrosinase inhibitor) combined with terrein. J Pharm Pharmacol. 60:343–348. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Lee JC, Yu MK, Lee R, Lee YH, Jeon JG, Lee MH, Jhee EC, Yoo ID and Yi HK: Terrein reduces pulpal inflammation in human dental pulp cells. J Endod. 34:433–437. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Lee YH, Lee NH, Bhattarai G, Oh YT, Yu MK, Yoo ID, Jhee EC and Yi HK: Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment. Cell Biochem Funct. 28:678–685. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kim DS, Lee HK, Park SH, Lee S, Ryoo IJ, Kim WG, Yoo ID, Na JI, Kwon SB and Park KC: Terrein inhibits keratinocyte proliferation via ERK inactivation and G2/M cell cycle arrest. Exp Dermatol. 17:312–317. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Arakawa M, Someno T, Kawada M and Ikeda D: A new terrein glucoside, a novel inhibitor of angiogenin secretion in tumor angiogenesis. J Antibiot. 61:442–448. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Liao WY, Shen CN, Lin LH, Yang YL, Han HY, Chen JW, Kuo SC, Wu SH and Liaw CC: Asperjinone, a nor-neolignan, and terrein, a suppressor of ABCG2-expressing breast cancer cells, from thermophilic Aspergillus terreus. J Nat Prod. 75:630–635. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Uthaisang W, Reutrakul V, Krachangchaeng C, Wilairat P and Fadeel B: VR-3848, a novel peptide derived from Euphobiaceae, induces mitochondria-dependent apoptosis in human leukemia cells. Cancer Lett. 208:171–178. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Oubrahim H, Stadtman ER and Chock PB: Mitochondria play no roles in Mn(II)-induced apoptosis in HeLa cells. Proc Natl Acad Sci USA. 98:9505–9510. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Feng Q, Cao HL, Xu W, Li XR, Ren YQ and Du LF: Apoptosis induced by genipin in human leukemia K562 cells: involvement of c-Jun N-terminal kinase in G2/M arrest. Acta Pharmacol Sin. 31:519–527. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Cossarizza A, Baccarani CM, Kalashnikova G and Franceschi C: A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1). Biochem Biophys Res Commun. 197:40–45. 1993.PubMed/NCBI

22 

Gomez-Lazaro M, Galindo MF, Concannon CG, Segura MF, Fernandez-Gomez FJ, Llecha N, Comella JX, Prehn JH and Jordan J: 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem. 104:1599–1612. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Puerto HLD, Martins AS, Milsted A, Souza-Fagundes EM, Braz GF, Hissa B, Andrade LO, Alves F, Rajão DS, Leite RC and Vasconcelos AC: Canine distemper virus induces apoptosis in cervical tumor derived cell lines. Virol J. 334:2–7. 2011.PubMed/NCBI

24 

Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Ashkenazi A: Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev. 19:325–331. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Gu Q, Wang JD, Xia HHX, Lin MC, He H, Zou B, Tu SP, Yang Y, Liu XG, Lam SK, Wong WM, Chan AO, Yuen MF, Kung HF and Wong BC: Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis. 26:541–546. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Budihardjo I, Oliver H, Lutter M, Luo X and Wang X: Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 15:269–290. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Ghobrial IM, Witzig TE and Adjei AA: Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 55:178–194. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR and Ashkenazi A: Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell. 137:721–735. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Kim SH, Kim SH, Lee SC and Song YS: Involvement of both extrinsic and intrinsic apoptotic pathways in apoptosis induced by genistein in human cervical cancer cells. Ann NY Acad Sci. 1171:196–201. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Hougardy BM, van der Zee AG, van den Heuvel FA, Timmer T, de Vries EG and de Jong S: Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid. Gynecol Oncol. 97:353–364. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Gross A, Jockel J, Wei MC and Korsmeyer SJ: Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17:3878–3885. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Yang W, Gong X, Zhao X, An W, Wang X and Wang M: Capsaicin induces apoptosis in HeLa cells via Bax/Bcl-2 and caspase-3 pathways. Asian J Traditional Med. 1:3–4. 2006.

34 

Mahfudh N and Pihie AHL: Eurycomanone induces apoptosis through the up-regulation of p53 in human cervical carcinoma cells. J Cancer Mol. 4:109–115. 2008.

35 

Priyadarsini RV, Murugan RS, Maitreyi S, Ramalingam K, Karunagaran D and Nagini S: The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol. 649:84–91. 2010.PubMed/NCBI

36 

Xu W, Liu J, Li C, Wu HZ and Liu YW: Kaempferol-7-O-β-D-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner. Cancer Lett. 264:229–240. 2008.

37 

Wang X, Martindale JL and Holbrook NJ: Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 275:39435–39443. 2000. View Article : Google Scholar

38 

Yeh PY, Chuang SE, Yeh KH, Song YC, Chang LLY and Cheng AL: Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. Oncogene. 23:3580–3588. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Wu Z, Wu LJ, Tashiro S, Onodera S and Ikejima T: Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis. Chin Med J. 118:671–677. 2005.PubMed/NCBI

40 

Singh M, Sharma H and Singh N: Hydrogen peroxide induces apoptosis in HeLa cells through mitochondrial pathway. Mitochondrion. 7:367–373. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Zhuang S and Schnellmann RG: A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther. 319:991–997. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Cagnol S and Chambard JC: ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J. 277:2–21. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Porameesanaporn Y, Uthaisang-Tanechpongtamb W, Jarintanan F, Jongrungruangchok S and Thanomsub Wongsatayanon B: Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation. Oncol Rep 29: 1600-1608, 2013.
APA
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., & Thanomsub Wongsatayanon, B. (2013). Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation. Oncology Reports, 29, 1600-1608. https://doi.org/10.3892/or.2013.2288
MLA
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., Thanomsub Wongsatayanon, B."Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation". Oncology Reports 29.4 (2013): 1600-1608.
Chicago
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., Thanomsub Wongsatayanon, B."Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation". Oncology Reports 29, no. 4 (2013): 1600-1608. https://doi.org/10.3892/or.2013.2288
Copy and paste a formatted citation
x
Spandidos Publications style
Porameesanaporn Y, Uthaisang-Tanechpongtamb W, Jarintanan F, Jongrungruangchok S and Thanomsub Wongsatayanon B: Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation. Oncol Rep 29: 1600-1608, 2013.
APA
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., & Thanomsub Wongsatayanon, B. (2013). Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation. Oncology Reports, 29, 1600-1608. https://doi.org/10.3892/or.2013.2288
MLA
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., Thanomsub Wongsatayanon, B."Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation". Oncology Reports 29.4 (2013): 1600-1608.
Chicago
Porameesanaporn, Y., Uthaisang-Tanechpongtamb, W., Jarintanan, F., Jongrungruangchok, S., Thanomsub Wongsatayanon, B."Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation". Oncology Reports 29, no. 4 (2013): 1600-1608. https://doi.org/10.3892/or.2013.2288
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