Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May 2013 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May 2013 Volume 29 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers

  • Authors:
    • Seong-Gon Kim
    • Je-Yong Choi
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea, Department of Biochemistry and Cell Biology, WCU program, CMRI, Skeletal Diseases Genome Research Center, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
  • Pages: 1835-1840
    |
    Published online on: February 19, 2013
       https://doi.org/10.3892/or.2013.2292
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The bacterial dormancy-inducing factor 4-hexylresorcinol (4-HR) has been shown to have synergistic antitumor effects when used in combination with cisplatin. In the present study, 4-HR was used as a single agent in the squamous carcinoma cell line SCC-9. The results demonstrated that 4-HR suppressed SCC-9 cell proliferation compared to primary cultured gingival fibroblasts. 4-HR dose-dependently induced SCC-9 cell apoptosis as determined by caspase-3 activity, annexin V expression, as well as by scanning and transmission electron microscopy. 4-HR inhibited intracellular calcium oscillation in both SCC-9 cells and normal human dermal fibroblasts. 4-HR-induced apoptosis was partly reversed by calcium channel blockers. Of note, 4-HR reduced the tumor mass formed by SSC-9 cell implantation in BALB/cAnNCrj-nu/nu mice and mass size reduction was also partly reversed by the concomitant application of calcium channel blockers. Collectively, our results suggest that 4-HR has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kozubek A and Tyman JHP: Resorcinolic lipids, the natural non-isoprenoid phenolic amphiphiles and their biological activity. Chem Rev. 99:1–25. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Mutoh M, Takahashi M, Fukuda K, et al: Suppression of cyclooxygenase-2 promoter-dependent transcription activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis. 21:959–963. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Hasegawa R, Furukawa F, Toyoda K, et al: Inhibitory effect of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats. Jpn J Cancer Res. 81:871–877. 1990.

4 

Maruyama H, Amamura T, Nakae D, et al: Effects of catechol and its analogs on pancreatic carcinogenesis initiated by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters. Carcinogenesis. 12:1331–1334. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG and Coman WB: Head and neck cancer: past, present and future. Expert Rev Anticancer Ther. 6:1111–1118. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Braakhuis BJ, Tabor MP, Kummer JA, Leemans CR and Brakenhoff RH: A genetic explanation of Slaughter’s concept of field cancerization: evidence and clinical implications. Cancer Res. 63:1727–1730. 2003.

7 

Reusch RN and Sadoff HL: 5-n-Alkylresorcinols from encysting Azotobacter vinelandii: isolation and characterization. J Bacteriol. 139:448–453. 1979.PubMed/NCBI

8 

Reusch RN and Sadoff HL: Novel lipid components of the Azotobacter vinelandii cyst membrane. Nature. 302:268–270. 1983. View Article : Google Scholar : PubMed/NCBI

9 

Osipov GA, El’-Registan GI, Svetlichnyi VA, Kozlova AN and Duda VV: Chemical nature of the autoregulating factor d1 in Pseudomonas carboxydoflava. Mikrobiologiia. 54:186–190. 1985.(In Russian).

10 

El’-Registan GI, Tsyshnatii GV, Duzha MV, Pronin SV and Mitiushina LL: Regulation of Pseudomonas carboxydoflavagrowth and development by specific endogenous factors. Mikrobiologiia. 49:561–565. 1980.(In Russian).

11 

Chhabra RS, Huff JE, Haseman J, Hall A, Baskin G and Cowan M: Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice. Fundam Appl Toxicol. 11:685–690. 1988. View Article : Google Scholar : PubMed/NCBI

12 

National Toxicology Program. NTP toxicology and carcinogenesis studies of 4-hexylresorcinol (CAS No. 136-77-6) in F344/N rats and B6C3F1 mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser. 330:1–166. 1988.PubMed/NCBI

13 

Kim SG, Lee SW, Park YW, Jeong JH and Choi JY: 4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells. Oncol Rep. 26:1527–1532. 2011.PubMed/NCBI

14 

Kim SG, Jeong JH, Park YW, et al: 4-hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. Oncol Rep. 25:1597–1602. 2011.PubMed/NCBI

15 

Kim SG, Kim AS, Jeong JH, Choi JY and Kweon H: 4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression. Oncol Rep. 28:677–681. 2012.PubMed/NCBI

16 

Grossi F and Aita M: Bevacizumab and non-small-cell lung cancer: starving the enemy to survive. Expert Opin Biol Ther. 7:1107–1119. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Trollinger DR, Cascio WE and Lemasters JJ: Selective loading of Rhod 2 into mitochondria shows mitochondrial Ca2+ transients during the contractile cycle in adult rabbit cardiac myocytes. Biochem Biophy Res Comm. 236:738–742. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Guejes L, Zurgil N, Deutsch M, Gilburd B and Shoenfeld Y: The influence of different cultivating conditions on polymorphonuclear leukocyte apoptotic processes in vitro, I: the morphological characteristics of PMN spontaneous apoptosis. Ultrastruct Pathol. 27:23–32. 2003. View Article : Google Scholar

19 

El-Azab MF and Moustafa YM: Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice. Pharmacol Rep. 64:305–314. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Luszczki JJ, Trojnar MK, Trojnar MP, et al: Effects of three calcium channel antagonists (amlodipine, diltiazem, and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock-induced seizure model. Pharmacol Rep. 59:672–682. 2007.

21 

Il’inskaya ON, Kolpakov AI, Mulyukin AL, Dreyer F and El’-Registan GI: Effects of membrane-active microbial autoregulators on the growth of cultured ras-transformed fibroblasts. Appl Biochem Microbiol. 36:473–477. 2000.PubMed/NCBI

22 

Yang LC, Ng DC and Bikle DD: Role of protein kinase Cα in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma. J Cell Physiol. 195:249–259. 2003.

23 

Jung HJ, Chen Z, Wang M, et al: Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. Blood. 119:2568–2578. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Rimando AM, Dayan FE and Streibig JC: PSII inhibitory activity of resorcinolic lipids from Sorghum bicolor. J Nat Prod. 66:42–45. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Kozubek A and Demel RA: Permeability changes of erythrocytes and liposomes by 5-(n-alk(en)yl) resorcinols from rye. Biochim Biophys Acta. 603:220–227. 1980. View Article : Google Scholar : PubMed/NCBI

26 

Hladyszowski K, Zubik L and Kozubek A: Quantum mechanical and experimental oxidation studies of pentadecylresorcinol, olivetol, orcinol and resorcinol. Free Radical Res. 28:359–368. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Bezzi P, Carmignoto G, Pasti L, et al: Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature. 391:281–285. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Parri HR, Gould TM and Crunelli V: Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nat Neurosci. 4:803–812. 2001. View Article : Google Scholar

29 

Choi SW, Park SY, Hong SP, Pai H, Choi JY and Kim SG: The expression of NMDA receptor 1 is associated with clinicopathological parameters and prognosis in the oral squamous cell carcinoma. J Oral Pathol Med. 33:533–537. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Schwerdt G, Freudinger R, Schuster C, Weber F, Thews O and Gekle M: Cisplatin-induced apoptosis is enhanced by hypoxia and by inhibition of mitochondria in renal collecting duct cells. Toxicol Sci. 85:735–742. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Robinson HM Jr: Effective antifungal drugs and indications for their use. Med Clin North Am. 51:1181–1188. 1967.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim S and Choi J: 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. Oncol Rep 29: 1835-1840, 2013.
APA
Kim, S., & Choi, J. (2013). 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. Oncology Reports, 29, 1835-1840. https://doi.org/10.3892/or.2013.2292
MLA
Kim, S., Choi, J."4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers". Oncology Reports 29.5 (2013): 1835-1840.
Chicago
Kim, S., Choi, J."4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers". Oncology Reports 29, no. 5 (2013): 1835-1840. https://doi.org/10.3892/or.2013.2292
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S and Choi J: 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. Oncol Rep 29: 1835-1840, 2013.
APA
Kim, S., & Choi, J. (2013). 4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. Oncology Reports, 29, 1835-1840. https://doi.org/10.3892/or.2013.2292
MLA
Kim, S., Choi, J."4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers". Oncology Reports 29.5 (2013): 1835-1840.
Chicago
Kim, S., Choi, J."4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers". Oncology Reports 29, no. 5 (2013): 1835-1840. https://doi.org/10.3892/or.2013.2292
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team