Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence

Saji,Hisashi; Tsuboi,Masahiro; Shimada,Yoshihisa; Kato,Yasufumi; Hamanaka,Wakako; Kudo,Yujin; Yoshida,Koichi; Matsubayashi,Jun; Usuda,Jitsuo; Ohira,Tatsuo; Ikeda,Norihiko

doi:10.3892/or.2013.2332

May 2013 Volume 29 Issue 5

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May 2013 Volume 29 Issue 5

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Article

Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence

Authors:
- Hisashi Saji
- Masahiro Tsuboi
- Yoshihisa Shimada
- Yasufumi Kato
- Wakako Hamanaka
- Yujin Kudo
- Koichi Yoshida
- Jun Matsubayashi
- Jitsuo Usuda
- Tatsuo Ohira
- Norihiko Ikeda
View Affiliations / Copyright

Affiliations: Division of Thoracic Surgery, Department of Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan, Department of Anatomic Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-0023, Japan
Pages: 1902-1906
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Published online on: March 6, 2013

https://doi.org/10.3892/or.2013.2332
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Abstract

Clinicohistopathological staging is insufficient to predict disease progression and clinical outcome in lung carcinoma. Based on the results of the principal component analysis of 24 samples of early-stage lung adenocarcinoma, two subgroups were identified within the early-relapse group. The histological classification of all samples of group A was poorly differentiated, whereas one out of three in group B was poorly differentiated. DAVID functional annotation analysis revealed that the molecular pathways enriched in group A included those associated with cell adhesion molecules (CAMs), cell cycle and antigen processing and presentation, whereas those in group B included CAMs, T cell receptor signaling, cytokine-cytokine receptor interaction, toll-like receptor signaling, chemokine signaling, primary immunodeficiency and natural killer cell-mediated cytotoxicity. The CAM pathway was enriched in both groups. This comprehensive gene expression and functional pathway analysis identified a distinct molecular pathway, CAMs, that correlated with the early relapse of patients with early-stage lung adenocarcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gene expression profiling and molecular pathway analysis for the identification of early-stage lung adenocarcinoma patients at risk for early recurrence

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