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Article

Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells

  • Authors:
    • Bregje van Oorschot
    • Suzanne E. Hovingh
    • Hans Rodermond
    • Ahmed Güçlü
    • Nienke Losekoot
    • Albert A. Geldof
    • Gerrit W. Barendsen
    • Lukas J. Stalpers
    • Nicolaas A.P. Franken
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Free University Hospital, Amsterdam, The Netherlands
  • Pages: 2175-2180
    |
    Published online on: March 26, 2013
       https://doi.org/10.3892/or.2013.2364
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Abstract

To determine the relationship between ionizing radiation-induced levels of γ-H2AX foci and cell survival in cultured prostate cancer cell lines, three prostate cancer cell lines: LNCaP (wt TP53), DU145 (mut TP53) and PC3 (TP53 null), were studied. For γ-H2AX foci induction, cells were irradiated with a single dose of 2 Gy and foci levels were studied at 30 min and 24 h after irradiation. Cell survival was determined by clonogenic assay, directly and 24 h after irradiation with doses ranging from 0 to 8 Gy. Irradiation was performed with a Siemens Stabilipan 250 KeV X-ray machine at a dose rate of approximately 3 Gy/min. Survival curves were analyzed using the linear-quadratic model S(D)/S(0) = exp-(αD+βD2). LNCaP cells clearly demonstrated potentially lethal damage repair (PLDR) which was assessed as increased survival levels after delayed plating as compared to cells plated immediately after irradiation. DU145 cells demonstrated only a slight PLDR and PC3 cells did not show PLDR at all. Levels of γ-H2AX foci were significantly decreased in all cell lines at 24 h after irradiation, compared to levels after 30 min. The LNCaP cells which demonstrated a clear PLDR also showed the largest decay in the number of γ-H2AX foci. In addition, the PC cells which did not show PLDR had the lowest decay of γ-H2AX foci. A clear correlation was demonstrated between the degree of decay of γ-H2AX foci and PLDR.
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View References

1 

Frankenberg-Schwager M: Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells. Radiat Environ Biophys. 29:273–292. 1990. View Article : Google Scholar : PubMed/NCBI

2 

Aten JA, Stap J, Krawczyk PM, van Oven CH, Hoebe RA, Essers J and Kanaar R: Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science. 303:92–95. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lau P, Baumstark-Khan C, Hellweg CE and Reitz G: X-irradiation-induced cell cycle delay and DNA double-strand breaks in the murine osteoblastic cell line OCT-1. Radiat Environ Biophys. 49:271–280. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Beels L, Werbrouck J and Thierens H: Dose response and repair kinetics of gamma-H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X- and gamma-radiation. Int J Radiat Biol. 86:760–768. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Vandersickel V, Depuydt J, Van Bockstaele B, Perletti G, Philippe J, Thierens H and Vral A: Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity. J Radiat Res. 51:633–641. 2010.

6 

Mosconi M, Giesen U, Langner F, Mielke C, Dalla Rosa I and Dirks WG: 53BP1 and MDC1 foci formation in HT-1080 cells for low- and high-LET microbeam irradiations. Radiat Environ Biophys. 50:345–352. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Zlobinskaya O, Dollinger G, Michalski D, Hable V, Greubel C, Du G, Multhoff G, Röper B, Molls M and Schmid TE: Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams. Radiat Environ Biophys. 51:23–32. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Olive PL and Banáth JP: Phosphorylation of histone H2AX as a measure of radiosensitivity. Int J Radiat Oncol Biol Phys. 58:331–335. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Hall EJ and Garcia AJ: Radiobiology for the Radiologist. 6th edition. Lippincott Williams & Wilkins; Philadelphia, PA: 2006

10 

Franken NA, van Bree C, Kipp JB and Barendsen GW: Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines. Int J Radiat Biol. 72:101–109. 1997. View Article : Google Scholar : PubMed/NCBI

11 

Franken N, van Bree C, Streefkerk J, Kuper I, Rodermond H, Kipp J and Barendsen G: Radiosensitization by iodo-deoxyuridine in cultured SW-1573 human lung tumor cells. Oncol Rep. 4:1073–1076. 1997.PubMed/NCBI

12 

Franken NA, Ruurs P, Ludwików G, van Bree C, Kipp JB, Darroudi F and Barendsen GW: Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells. Int J Radiat Biol. 75:293–299. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Franken NA, van Bree C, Veltmaat MA, Ludwików G, Kipp JB and Barendsen GW: Increased chromosome exchange frequencies in iodo-doxyuridine-sensitized human SW-1573 cells after γ-irradiation. Oncol Rep. 6:59–63. 1999.PubMed/NCBI

14 

Schwartz JL, Jordan R, Kaufmann WK, Rasey J, Russell KJ and Weichselbaum RR: Evidence for the expression of radiation-induced potentially lethal damage being a p53-dependent process. Int J Radiat Biol. 76:1037–1043. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Schwartz JL, Rasey J, Wiens L, Jordan R and Russell KJ: Functional inactivation of p53 by HPV-E6 transformation is associated with a reduced expression of radiation-induced potentially lethal damage. Int J Radiat Biol. 75:285–291. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Franken NA, van Bree C, ten Cate R, van Oven CH and Haveman J: Importance of TP53 and RB in the repair of potentially lethal damage and induction of color junctions after exposure to ionizing radiation. Radiat Res. 158:707–714. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Franken NA, van Bree C and Haveman J: Differential response to radiation of TP53-inactivated cells by overexpression of dominant-negative mutant TP53 or HPVE6. Radiat Res. 161:504–510. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Devlin HL, Mack PC, Burich RA, Gumerlock PH, Kung HJ, Mudryj M and deVere White RW: Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells. Mol Cancer Res. 6:808–818. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Danielsen T, Smith-Sørensen B, Grønlund HA, Hvidsten M, Børresen-Dale AL and Rofstad EK: No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines. Int J Radiat Biol. 75:1149–1160. 1999. View Article : Google Scholar : PubMed/NCBI

20 

van Bree C, Savonije JH, Franken NA, Haveman J and Bakker PJ: The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells. Int J Oncol. 16:739–744. 2000.PubMed/NCBI

21 

van Bree C, Franken NA, Rodermond HM, Stalpers LJ and Haveman J: Repair of potentially lethal damage does not depend on functional TP53 in human glioblastoma cells. Radiat Res. 161:511–516. 2004.

22 

Barendsen GW: Dose fractionation, dose rate and iso-effect relationships for normal tissue responses (review). Int J Radiat Oncol Biol Phys. 8:1981–1997. 1982. View Article : Google Scholar : PubMed/NCBI

23 

Barendsen GW: RBE-LET relationships for different types of lethal radiation damage in mammalian cells: comparison with DNA dsb and an interpretation of differences in radiosensitivity. Int J Radiat Biol. 66:433–436. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Barendsen GW: Parameters of linear-quadratic radiation dose-effect relationships: dependence on LET and mechanisms of reproductive cell death. Int J Radiat Biol. 71:649–655. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Barendsen GW: Sublethal damage and DNA double strand breaks have similar RBE-LET relationships: evidence and implications. Int J Radiat Biol. 63:325–330. 1993. View Article : Google Scholar : PubMed/NCBI

26 

Barendsen GW: The relationships between RBE and LET for different types of lethal damage in mammalian cells: biophysical and molecular mechanisms (review). Radiat Res. 139:257–270. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Barendsen GW, van Bree C and Franken NA: Importance of cell proliferative state and potentially lethal damage repair on radiation effectiveness: Implications for combined tumor treatments (Review). Int J Oncol. 19:247–256. 2001.PubMed/NCBI

28 

Franken NA, Hovingh S, Rodermond H, Stalpers L, Barendsen GW and Crezee J: Radiosensitization with chemotherapeutic agents and hyperthermia: Effects on the linear-quadratic parameters of radiation cell survival curves. J Cancer Sci Ther S. 5:002 View Article : Google Scholar : 2011.

29 

Franken NA, Hovingh S, Oei A, Cobussen P, Bergs JW, van Bree C, Rodermond HM, Stalpers LJ, Kok P, Barendsen GW and Crezee J: Radiosensitization with hyperthermia and chemotherapeutic agents: Effects on linear-quadratic parameters of radiation cell survival curves (Review). Ionizing Radiation/Book 1. Mitsuru N. Intech Publisher; 2012

30 

van Bree C, Franken NA, Bakker PJ, Klomp-Tukker LJ, Barendsen GW and Kipp JB: Hyperthermia and incorporation of halogenated pyrimidines: radiosensitization in cultured rodent and human tumor cells. Int J Radiat Oncol Biol Phys. 39:489–496. 1997.PubMed/NCBI

31 

Yoshikawa T, Kashino G, Ono K and Watanabe M: Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities. J Radiat Res. 50:151–160. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Dikomey E and Brammer I: Relationship between cellular radiosensitivity and non-repaired double-strand breaks studied for different growth states, dose rates and plating conditions in a normal human fibroblast line. Int J Radiat Biol. 76:773–781. 2000. View Article : Google Scholar

33 

Banáth JP, Klokov D, MacPhail SH, Banuelos CA and Olive PL: Residual gammaH2AX foci as an indication of lethal DNA lesions. BMC Cancer. 10:42010.PubMed/NCBI

34 

Klokov D, MacPhail SM, Banáth JP, Byrne JP and Olive PL: Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays. Radiother Oncol. 80:223–229. 2006. View Article : Google Scholar : PubMed/NCBI

35 

DeWeese TL, Shipman JM, Dillehay LE and Nelson WG: Sensitivity of human prostatic carcinoma cell lines to low dose rate radiation exposure. J Urol. 159:591–598. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Geldof AA and Slotman BJ: Radiosensitizing effect of cisplatin in prostate cancer cell lines. Cancer Lett. 101:233–239. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Geldof AA, Plaizier MA, Duivenvoorden I, Ringelberg M, Versteegh RT, Newling DW and Teule GJ: Cell cycle perturbations and radiosensitization effects in a human prostate cancer cell line. J Cancer Res Clin Oncol. 129:175–182. 2003.PubMed/NCBI

38 

Franken NAP, Rodermond HM, Stap J, Haveman J and van Bree C: Clonogenic assay of cells in vitro. Nat Protoc. 1:2315–2319. 2006. View Article : Google Scholar

39 

Bergs JW, Franken NA, ten Cate R, van Bree C and Haveman J: Effects of cisplatin and gamma-irradiation on cell survival, the induction of chromosomal aberrations and apoptosis in SW-1573 cells. Mutat Res. 594:148–154. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Franken NA, van Bree C, Veltmaat MA, Rodermond HM, Haveman J and Barendsen GW: Radiosensitization by bromodeoxyuridine and hyperthermia: analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines. J Radiat Res. 42:179–190. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Franken NA, ten Cate R, van Bree C and Haveman J: Induction of the early response protein EGR-1 in human tumour cells after ionizing radiation is correlated with a reduction of repair of lethal lesions and an increase of repair of sublethal lesions. Int J Oncol. 24:1027–1031. 2004.

42 

Franken NA, ten Cate R, Krawczyk PM, Stap J, Haveman J, Aten J and Barendsen GW: Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death. Radiat Oncol. 6:642011.

43 

Franken NA, Hovingh SE, ten Cate R, Krawczyk PM, Stap J, Hoebe R, Aten J and Barendsen GW: Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells. Oncol Rep. 27:769–774. 2012.

44 

Ludwików G, Xiao Y, Hoebe RA, Franken NA, Darroudi F, Stap J, Van Oven CH, Van Noorden CJ and Aten J: Induction of chromosome aberrations in unirradiated chromatin after partial irradiation of a cell nucleus. Int J Radiat Biol. 78:239–247. 2002.PubMed/NCBI

45 

Bergs JW, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJ, Kanaar R, Aten J and Franken NA: Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. DNA Repair (Amst). 12:38–45. 2013. View Article : Google Scholar : PubMed/NCBI

46 

MacPhail SH, Banáth JP, Yu TY, Chu EH, Lambur H and Olive PL: Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays. Int J Radiat Biol. 79:351–358. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
van Oorschot B, Hovingh SE, Rodermond H, Güçlü A, Losekoot N, Geldof AA, Barendsen GW, Stalpers LJ and Franken NA: Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells. Oncol Rep 29: 2175-2180, 2013.
APA
van Oorschot, B., Hovingh, S.E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A.A. ... Franken, N.A. (2013). Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells. Oncology Reports, 29, 2175-2180. https://doi.org/10.3892/or.2013.2364
MLA
van Oorschot, B., Hovingh, S. E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A. A., Barendsen, G. W., Stalpers, L. J., Franken, N. A."Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells". Oncology Reports 29.6 (2013): 2175-2180.
Chicago
van Oorschot, B., Hovingh, S. E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A. A., Barendsen, G. W., Stalpers, L. J., Franken, N. A."Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells". Oncology Reports 29, no. 6 (2013): 2175-2180. https://doi.org/10.3892/or.2013.2364
Copy and paste a formatted citation
x
Spandidos Publications style
van Oorschot B, Hovingh SE, Rodermond H, Güçlü A, Losekoot N, Geldof AA, Barendsen GW, Stalpers LJ and Franken NA: Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells. Oncol Rep 29: 2175-2180, 2013.
APA
van Oorschot, B., Hovingh, S.E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A.A. ... Franken, N.A. (2013). Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells. Oncology Reports, 29, 2175-2180. https://doi.org/10.3892/or.2013.2364
MLA
van Oorschot, B., Hovingh, S. E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A. A., Barendsen, G. W., Stalpers, L. J., Franken, N. A."Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells". Oncology Reports 29.6 (2013): 2175-2180.
Chicago
van Oorschot, B., Hovingh, S. E., Rodermond, H., Güçlü, A., Losekoot, N., Geldof, A. A., Barendsen, G. W., Stalpers, L. J., Franken, N. A."Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells". Oncology Reports 29, no. 6 (2013): 2175-2180. https://doi.org/10.3892/or.2013.2364
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