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Article

Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma

  • Authors:
    • Kedong Xu
    • Jie Gao
    • Xue Yang
    • Yingmin Yao
    • Qingguang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Hospital of Xi'an Jiaotong University, College of Medicine, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 2211-2218
    |
    Published online on: March 26, 2013
       https://doi.org/10.3892/or.2013.2366
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Abstract

Cytohesin-2 is overexpressed in human lung cancer and it activates cytoplasmic ErbB receptors. Inhibition of cytohesin-2 by SecinH3 reduces growth of EGFR-dependent lung cancer xenografts and improves the treatment of primarily EGFR-TKI-resistant lung cancers. Cytohesin-2 promotes HepG2 proliferation through the IGF pathway, and VEGF-dependent initiation of angiogenesis by regulation of VEGFR-2 internalization in endothelial cells, vessel permeability and ultimately endothelial proliferation. The purpose of this study was to evaluate the effects of cytohesin-2 in hepatocellular carcinoma (HCC) . In the current study, we collected 40 HCC tissues and detected cytohesin-2 mRNA expression in the 40 HCC tissues by using quantitative real-time polymerase chain reaction (qRT-PCR), as well as its protein expression by using immunohistochemistry and western blot analysis. We found that cytohesin-2 was more highly expressed in HCC compared to adjacent non-tumorous liver tissues, and cytohesin-2 expression was significantly increased in specimens with high α-fetoprotein and vascular invasion. Both univariate and multivariate analyses indicated that there is an association between cytohesin-2 expression and overall survival (OS) and disease-free survival (DFS). Moreover, stratified analysis showed that patients in tumor-node-metastasis (TNM) stage I with higher cytohesin-2 levels had shorter OS and DFS than those with lower cytohesin-2 levels. In conclusion, cytohesin-2 may identify low-and high-risk individuals with HCC and may be a valuable indicator for stratifying prognosis of TNM stage I patients. Cytohesin-2 may serve as a novel prognostic biomarker for HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Xu K, Gao J, Yang X, Yao Y and Liu Q: Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma. Oncol Rep 29: 2211-2218, 2013.
APA
Xu, K., Gao, J., Yang, X., Yao, Y., & Liu, Q. (2013). Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma. Oncology Reports, 29, 2211-2218. https://doi.org/10.3892/or.2013.2366
MLA
Xu, K., Gao, J., Yang, X., Yao, Y., Liu, Q."Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma". Oncology Reports 29.6 (2013): 2211-2218.
Chicago
Xu, K., Gao, J., Yang, X., Yao, Y., Liu, Q."Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma". Oncology Reports 29, no. 6 (2013): 2211-2218. https://doi.org/10.3892/or.2013.2366
Copy and paste a formatted citation
x
Spandidos Publications style
Xu K, Gao J, Yang X, Yao Y and Liu Q: Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma. Oncol Rep 29: 2211-2218, 2013.
APA
Xu, K., Gao, J., Yang, X., Yao, Y., & Liu, Q. (2013). Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma. Oncology Reports, 29, 2211-2218. https://doi.org/10.3892/or.2013.2366
MLA
Xu, K., Gao, J., Yang, X., Yao, Y., Liu, Q."Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma". Oncology Reports 29.6 (2013): 2211-2218.
Chicago
Xu, K., Gao, J., Yang, X., Yao, Y., Liu, Q."Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma". Oncology Reports 29, no. 6 (2013): 2211-2218. https://doi.org/10.3892/or.2013.2366
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