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Article

Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib

  • Authors:
    • Lisa C. Crowley
    • Tracey R. O'Donovan
    • Michelle J. Nyhan
    • Sharon L. McKenna
  • View Affiliations / Copyright

    Affiliations: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork, Cork, Ireland
  • Pages: 2261-2268
    |
    Published online on: April 3, 2013
       https://doi.org/10.3892/or.2013.2377
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Abstract

Resistance to tyrosine kinase inhibitors (TKIs) remains a limitation to the treatment of chronic myeloid leukaemia (CML), due in part, to the induction of autophagy. We examined whether disruption of autophagy with the pharmacological agents, brefeldin A, vincristine and chloroquine, improves the cytotoxicity of imatinib. In K562 CML cells, all drugs tested, in combination with imatinib impaired the expression or cellular distribution of LC3 and Beclin 1 (autophagy markers) and reduced the recovery of cells following drug withdrawal. The combination of imatinib and an agent that impedes autophagy demonstrates impressive potential as a more curative regime for CML.
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Copy and paste a formatted citation
Spandidos Publications style
Crowley LC, O'Donovan TR, Nyhan MJ and McKenna SL: Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib. Oncol Rep 29: 2261-2268, 2013.
APA
Crowley, L.C., O'Donovan, T.R., Nyhan, M.J., & McKenna, S.L. (2013). Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib. Oncology Reports, 29, 2261-2268. https://doi.org/10.3892/or.2013.2377
MLA
Crowley, L. C., O'Donovan, T. R., Nyhan, M. J., McKenna, S. L."Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib". Oncology Reports 29.6 (2013): 2261-2268.
Chicago
Crowley, L. C., O'Donovan, T. R., Nyhan, M. J., McKenna, S. L."Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib". Oncology Reports 29, no. 6 (2013): 2261-2268. https://doi.org/10.3892/or.2013.2377
Copy and paste a formatted citation
x
Spandidos Publications style
Crowley LC, O'Donovan TR, Nyhan MJ and McKenna SL: Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib. Oncol Rep 29: 2261-2268, 2013.
APA
Crowley, L.C., O'Donovan, T.R., Nyhan, M.J., & McKenna, S.L. (2013). Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib. Oncology Reports, 29, 2261-2268. https://doi.org/10.3892/or.2013.2377
MLA
Crowley, L. C., O'Donovan, T. R., Nyhan, M. J., McKenna, S. L."Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib". Oncology Reports 29.6 (2013): 2261-2268.
Chicago
Crowley, L. C., O'Donovan, T. R., Nyhan, M. J., McKenna, S. L."Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib". Oncology Reports 29, no. 6 (2013): 2261-2268. https://doi.org/10.3892/or.2013.2377
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