Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

Nagamine,Kyosuke; Kitamura,Tetsuya; Yanagawa-Matsuda,Aya; Ohiro,Yoichi; Tei,Kanchu; Hida,Kyoko; Higashino,Fumihiro; Totsuka,Yasunori; Shindoh,Masanobu

doi:10.3892/or.2013.2393

June 2013 Volume 29 Issue 6

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June 2013 Volume 29 Issue 6

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Article Open Access

Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

Authors:
- Kyosuke Nagamine
- Tetsuya Kitamura
- Aya Yanagawa-Matsuda
- Yoichi Ohiro
- Kanchu Tei
- Kyoko Hida
- Fumihiro Higashino
- Yasunori Totsuka
- Masanobu Shindoh
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Affiliations: Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-ku, Sapporo 060-8586, Japan, Department of Oral and Maxillofacial Surgery, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-ku, Sapporo 060-8586, Japan, Department of Vascular Biology, Hokkaido University Graduate School of Dental Medicine, N13 W7, Kita-ku, Sapporo 060-8586, Japan

Copyright: © Nagamine et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
Pages: 2114-2118
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Published online on: April 8, 2013

https://doi.org/10.3892/or.2013.2393
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Abstract

Parathyroid hormone-related protein (PTHrP) is known to induce bone resorption by activating RANKL as well as PTH. PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. PTHrP expression in oral squamous carcinoma cell lines was investigated, and PTHrP was expressed in oral squamous cell carcinoma cell lines similar to that in a prostate carcinoma cell line. Mucoepidermoid carcinoma is the most common malignant salivary gland tumor composed of different types of cells including a squamous component. Its clinical behavior is highly variable and ranges from slow-growing and indolent to locally aggressive and highly metastatic. We examined the PTHrP expression in mucoepidermoid carcinoma and assessed the significance of its correlation with clinicopathological features. Immunohistochemical detection of PTHrP was carried out in 21 cases of mucoepidermoid carcinoma in the head and neck region. PTHrP was highly detectable in intermediate and epidermoid cells, and abundant expression of PTHrP in intermediate cells had a significant association with cancer malignancy, including lymph node metastasis and/or tumor recurrence. These results suggest that PTHrP expression can be used as a prognostic factor for mucoepidermoid carcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma

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Abstract

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