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Article

Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo

Corrigendum in: /10.3892/or.2024.8783
  • Authors:
    • Chong Zhang
    • Shuang-Shuang Zhou
    • Xiang-Rong Li
    • Bao-Ming Wang
    • Neng-Ming Lin
    • Lin-Yi Feng
    • Da-Yong Zhang
    • Li-Huang Zhang
    • Jun-Bo Wang
    • Jian-Ping Pan
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, P.R. China, Laboratory of Clinical Pharmacy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 2275-2282
    |
    Published online on: April 12, 2013
       https://doi.org/10.3892/or.2013.2405
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Abstract

The present study showed that the combination of dasatinib and combretastatin A-4 (CA-4) exhibited synergistic cytotoxicity in multiple types of cancer, including ovarian, hepatocellular, lung and prostate carcinoma. The enhanced apoptosis induced by dasatinib plus CA-4 was accompanied by a greater extent of mitochondrial depolarization, caspase-3 activation and PARP cleavage in HO-8910 cells. Furthermore, elevated expression of Mcl-1 led to a reduced apoptosis induced by dasatinib plus CA-4, highlighting that downregulated Mcl-1 was necessary for the potentiating effect of dasatinib to CA-4-triggered apoptosis. A clear increase in γ-H2AX expression was observed in the dasatinib + CA-4 group compared with the mono-treatment groups, indicating that dasatinib plus CA-4 may induce double-strand breaks (DSBs) in HO-8910 cells. Moreover, the increased anticancer efficacy of dasatinib combined with CA-4 was further validated in a human HO-8910 ovarian cancer xenograft model in nude mice. Our study is the first to show that the combination of dasatinib with CA-4 could be a novel and promising therapeutic approach for the treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Zhou S, Li X, Wang B, Lin N, Feng L, Zhang D, Zhang L, Wang J, Pan J, Pan J, et al: Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783. Oncol Rep 29: 2275-2282, 2013.
APA
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L. ... Pan, J. (2013). Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783. Oncology Reports, 29, 2275-2282. https://doi.org/10.3892/or.2013.2405
MLA
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L., Zhang, D., Zhang, L., Wang, J., Pan, J."Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783". Oncology Reports 29.6 (2013): 2275-2282.
Chicago
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L., Zhang, D., Zhang, L., Wang, J., Pan, J."Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783". Oncology Reports 29, no. 6 (2013): 2275-2282. https://doi.org/10.3892/or.2013.2405
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Zhou S, Li X, Wang B, Lin N, Feng L, Zhang D, Zhang L, Wang J, Pan J, Pan J, et al: Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783. Oncol Rep 29: 2275-2282, 2013.
APA
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L. ... Pan, J. (2013). Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783. Oncology Reports, 29, 2275-2282. https://doi.org/10.3892/or.2013.2405
MLA
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L., Zhang, D., Zhang, L., Wang, J., Pan, J."Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783". Oncology Reports 29.6 (2013): 2275-2282.
Chicago
Zhang, C., Zhou, S., Li, X., Wang, B., Lin, N., Feng, L., Zhang, D., Zhang, L., Wang, J., Pan, J."Enhanced antitumor activity by the combination of dasatinib and combretastatin A-4 in vitro and in vivo Corrigendum in /10.3892/or.2024.8783". Oncology Reports 29, no. 6 (2013): 2275-2282. https://doi.org/10.3892/or.2013.2405
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