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Article

S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas

  • Authors:
    • Ying Zhao
    • Tianbiao Zhang
    • Qiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 111-118
    |
    Published online on: April 23, 2013
       https://doi.org/10.3892/or.2013.2419
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Abstract

Overexpression of the S100 calcium‑binding protein A4 (S100A4) is involved in epithelial-to-mesenchymal transition, oncogenic transformation, angiogenesis, cytoskeletal integrity and cancer metastasis. Here, we elucidated the role of S100A4 in tumorigenesis and progression of gastric carcinomas. S100A4 expression in gastric carcinomas, adenomas and adjacent non-neoplastic mucosa was analyzed by immunohistochemical, real-time reverse transcriptase (RT)-polymerase chain reaction (PCR) and western blot analyses, and was correlated with various clinicopathological parameters. S100A4 protein expression was increased gradually in the following order: gastritis (19.2%), intestinal metaplasia (IM; 23.3%), dysplasia (34.9%) and carcinoma (55.2%; P<0.001). S100A4 was positively correlated with tumor size, depth of invasion, lymphatic invasion, lymph node metastasis and tumor-node-metastasis (TNM) staging (P<0.05), but not with the age and gender of the carcinoma patients (P>0.05). Intestinal-type (IT) carcinomas showed a higher S100A4 expression than diffuse-type (DT) carcinomas (P<0.001). S100A4 mRNA expression also increased in the following order: gastritis < IM < dysplasia < carcinoma (P<0.05). S100A4 overexpression was observed in gastric carcinomas with a larger diameter, deeper invasion, lymph node metastasis and in IT carcinoma (P<0.05). Univariate analysis using the Kaplan-Meier method indicated a lower cumulative survival rate for patients with weak or moderate S100A4 expression compared with patients not expressing S100A4 (P<0.001). Multivariate analysis using Cox's proportional hazard model demonstrated that depth of invasion, lymphatic or venous invasion, lymph node metastasis, TNM staging and S100A4 expression were independent factors for poor patient prognosis (P<0.05). In conclusion, S100A4 upregulation is positively associated with the pathogenesis, growth, invasion, metastasis and differentiation of gastric carcinomas. S100A4 may be a promising marker indicative of the aggressive behavior and prognosis of gastric carcinomas.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Zhang T and Wang Q: S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Oncol Rep 30: 111-118, 2013.
APA
Zhao, Y., Zhang, T., & Wang, Q. (2013). S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Oncology Reports, 30, 111-118. https://doi.org/10.3892/or.2013.2419
MLA
Zhao, Y., Zhang, T., Wang, Q."S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas". Oncology Reports 30.1 (2013): 111-118.
Chicago
Zhao, Y., Zhang, T., Wang, Q."S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas". Oncology Reports 30, no. 1 (2013): 111-118. https://doi.org/10.3892/or.2013.2419
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Zhang T and Wang Q: S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Oncol Rep 30: 111-118, 2013.
APA
Zhao, Y., Zhang, T., & Wang, Q. (2013). S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas. Oncology Reports, 30, 111-118. https://doi.org/10.3892/or.2013.2419
MLA
Zhao, Y., Zhang, T., Wang, Q."S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas". Oncology Reports 30.1 (2013): 111-118.
Chicago
Zhao, Y., Zhang, T., Wang, Q."S100 calcium-binding protein A4 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas". Oncology Reports 30, no. 1 (2013): 111-118. https://doi.org/10.3892/or.2013.2419
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