Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
August 2013 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 2013 Volume 30 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates

  • Authors:
    • Jing Lu
    • Ruihua Bai
    • Zhenzhu Qin
    • Yanyan Zhang
    • Xiaoyan Zhang
    • Yanan Jiang
    • Hongyan Yang
    • Youtian Huang
    • Gang Li
    • Mingyao Zhao
    • Ziming Dong
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China, Department of Pathology, Henan Tumor Hospital, Zhengzhou 450003, P.R. China, Department of Pathology, The First People's Hospital of Shangqiu, Shangqiu 476100, P.R. China, Department of Dermatology and Skin Science, Research Pavilion, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada
  • Pages: 739-744
    |
    Published online on: May 23, 2013
       https://doi.org/10.3892/or.2013.2491
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

We previously reported endothelial-like differentiation (ELD) of immature dendritic cells (iDCs) in the microenvironment derived from EC9706 human esophageal squamous cell carcinoma conditioned medium (CM). However, the CM is far different from the esophageal carcinoma tissue of patients. In addition, the potential role of peri-esophageal carcinoma in the ELD of iDCs is also unknown. In the present study, we showed that the tumor microenvironment derived from esophageal carcinoma homogenate promoted iDCs to differentiate from the DC pathway toward endothelial cells, while the peri-esophageal carcinoma homogenate did not have this function. During the course of ELD, ERK signaling pathway and CREB were activated. Blocking MEK, both the phosphorylation of ERK and CREB, and the ELD of iDCs were inhibited. These data suggest that esophageal carcinoma tissue, not peri-esophageal carcinoma tissue, can drive iDCs to differentiate into endothelial-like cells, instead of differentiation into mature DCs, thereby losing the ability of antigen presentation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Xue G, Cheng Y, Ran F, et al: SLC gene-modified dendritic cells mediate T cell-dependent anti-gastric cancer immune responses in vitro. Oncol Rep. 29:595–604. 2013.PubMed/NCBI

2 

Wu H, Han Y, Qin Y, et al: Whole-cell vaccine coated with recombinant calreticulin enhances activation of dendritic cells and induces tumour-specific immune responses. Oncol Rep. 29:529–534. 2013.PubMed/NCBI

3 

Giardino Torchia ML, Ciaglia E, Masci AM, et al: Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors. PLoS One. 5:e110522010.PubMed/NCBI

4 

Demoulin S, Herfs M, Delvenne P and Hubert P: Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms. J Leukoc Biol. 93:343–352. 2012. View Article : Google Scholar

5 

Benencia F, Sprague L, McGinty J, Pate M and Muccioli M: Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination. J Biomed Biotechnol. 2012:4254762012. View Article : Google Scholar : PubMed/NCBI

6 

Conejo-Garcia JR, Benencia F, Courreges MC, et al: Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med. 10:950–958. 2004.

7 

Young MR and Cigal M: Tumor skewing of CD34+ cell differentiation from a dendritic cell pathway into endothelial cells. Cancer Immunol Immunother. 55:558–568. 2006.

8 

Gottfried E, Kreutz M, Haffner S, et al: Differentiation of human tumour-associated dendritic cells into endothelial-like cells: an alternative pathway of tumour angiogenesis. Scand J Immunol. 65:329–335. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Sozzani S, Rusnati M, Riboldi E, Mitola S and Presta M: Dendritic cell-endothelial cell cross-talk in angiogenesis. Trends Immunol. 28:385–392. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Lu J, Zhao J, Liu K, et al: MAPK/ERK1/2 signaling mediates endothelial-like differentiation of immature DCs in the microenvironment of esophageal squamous cell carcinoma. Cell Mol Life Sci. 67:2091–2106. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Muftuoglu TM, Koksal N and Ozkutlu D: Evaluation of phagocytic function of macrophages in rats after partial splenectomy. J Am Coll Surg. 191:668–671. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Aranguren XL, Luttun A, Clavel C, et al: In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells. Blood. 109:2634–2642. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Li Z, Wu JC, Sheikh AY, et al: Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation. 116:I46–I54. 2007.PubMed/NCBI

14 

Conejo-Garcia JR, Buckanovich RJ, Benencia F, et al: Vascular leukocytes contribute to tumor vascularization. Blood. 105:679–681. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Rehman J, Li J, Orschell CM and March KL: Peripheral blood ‘endothelial progenitor cells’ are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 107:1164–1169. 2003.

16 

Fernandez Pujol B, Lucibello FC, Zuzarte M, Lutjens P, Muller R and Havemann K: Dendritic cells derived from peripheral monocytes express endothelial markers and in the presence of angiogenic growth factors differentiate into endothelial-like cells. Eur J Cell Biol. 80:99–110. 2001.

17 

Said N and Theodorescu D: RhoGDI2 suppresses bladder cancer metastasis via reduction of inflammation in the tumor microenvironment. Oncoimmunology. 1:1175–1177. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Fessler E, Dijkgraaf FE, De Sousa EMF and Medema JP: Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame? Cancer Lett. 12:00603–00609. 2012.PubMed/NCBI

19 

Kusmartsev S and Gabrilovich DI: Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer. Cancer Metastasis Rev. 25:323–331. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Muthana M, Fairburn B, Mirza S, Slack LK, Hopkinson K and Pockley AG: Identification of a rat bone marrow-derived dendritic cell population which secretes both IL-10 and IL-12: evidence against a reciprocal relationship between IL-10 and IL-12 secretion. Immunobiology. 211:391–402. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Michielsen AJ, O’Sullivan JN and Ryan EJ: Tumor conditioned media from colorectal cancer patients inhibits dendritic cell maturation. Oncoimmunology. 1:751–753. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Hurwitz AA and Watkins SK: Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells. Cancer Immunol Immunother. 61:289–293. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Tamminen JA, Myllarniemi M, Hyytiainen M, Keski-Oja J and Koli K: Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling. J Cell Biochem. 113:2234–2247. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Shi Y, Xia YY, Wang L, Liu R, Khoo KS and Feng ZW: Neural cell adhesion molecule modulates mesenchymal stromal cell migration via activation of MAPK/ERK signaling. Exp Cell Res. 318:2257–2267. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wu W, Sun Z, Wu J, et al: Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PLoS One. 7:e299202012. View Article : Google Scholar : PubMed/NCBI

26 

Gomez M, Manzano A, Figueras A, et al: Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway. Am J Physiol Endocrinol Metab. 303:E695–E707. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Guo Y and Feng P: OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 318:2004–2013. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kido S, Kuriwaka-Kido R, Imamura T, Ito Y, Inoue D and Matsumoto T: Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone. 45:1125–1132. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Choi HJ, Park YG and Kim CH: Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells. Mol Cells. 23:138–144. 2007.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu J, Bai R, Qin Z, Zhang Y, Zhang X, Jiang Y, Yang H, Huang Y, Li G, Zhao M, Zhao M, et al: Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates. Oncol Rep 30: 739-744, 2013.
APA
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y. ... Dong, Z. (2013). Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates. Oncology Reports, 30, 739-744. https://doi.org/10.3892/or.2013.2491
MLA
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y., Yang, H., Huang, Y., Li, G., Zhao, M., Dong, Z."Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates". Oncology Reports 30.2 (2013): 739-744.
Chicago
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y., Yang, H., Huang, Y., Li, G., Zhao, M., Dong, Z."Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates". Oncology Reports 30, no. 2 (2013): 739-744. https://doi.org/10.3892/or.2013.2491
Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Bai R, Qin Z, Zhang Y, Zhang X, Jiang Y, Yang H, Huang Y, Li G, Zhao M, Zhao M, et al: Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates. Oncol Rep 30: 739-744, 2013.
APA
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y. ... Dong, Z. (2013). Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates. Oncology Reports, 30, 739-744. https://doi.org/10.3892/or.2013.2491
MLA
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y., Yang, H., Huang, Y., Li, G., Zhao, M., Dong, Z."Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates". Oncology Reports 30.2 (2013): 739-744.
Chicago
Lu, J., Bai, R., Qin, Z., Zhang, Y., Zhang, X., Jiang, Y., Yang, H., Huang, Y., Li, G., Zhao, M., Dong, Z."Differentiation of immature DCs into endothelial-like cells in human esophageal carcinoma tissue homogenates". Oncology Reports 30, no. 2 (2013): 739-744. https://doi.org/10.3892/or.2013.2491
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team