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Article

Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells

  • Authors:
    • Guodong Zhu
    • Jiancheng Zhou
    • Wenbin Song
    • Dapeng Wu
    • Qiang Dang
    • Linlin Zhang
    • Lei Li
    • Xinyang Wang
    • Dalin He
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of the Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. China
  • Pages: 904-910
    |
    Published online on: June 11, 2013
       https://doi.org/10.3892/or.2013.2534
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Abstract

Epidermal growth factor (EGF) signaling and Hedgehog (HH) signaling are both involved in prostate cancer (PCa) progression, yet the mechanisms through which these two pathways are synergistically linked require elucidation. In the present study, we aimed to ascertain how EGF and the HH signaling transcription factor GLI-1 are linked in prostate cancer invasiveness. ARCaP human prostate cancer cells, which included ARCaPE and ARCaPM cells, were used as a model in the present study. The expression of EGF receptor (EGFR) and the HH signaling transcriptional factor GLI-1 were detected in ARCaPE cells by immunofluorescence, and the ARCaPE cells were treated with human recombinant EGF protein (hrEGF) for 4 consecutive days in vitro. Transwell invasion assays were performed in the ARCaPE cells following treatment with DMSO (vehicle control), hrEGF, GATN61 (GLI-1-specific inhibitor), hrEGF plus GANT61 and in the ARCaPM cells. The expression of phosphorylated extracellular signal regulated kinase (p-ERK), total ERK and GLI-1 was detected by western blotting in ARCaPE cells at different time-points following treatment with hrEGF. The expression of EGFR and GLI-1 was detected in ARCaPE cells, which exhibited a cobblestone-like morphology, while after treatment with hrEGF, the cell morphology was altered to a spindle-shaped mesenchymal cell morphology. Transwell invasion assays demonstrated that hrEGF dramatically enhanced the invasive capability of the ARCaPE cells (p<0.05). Additionally, western blot assay demonstrated that the expression levels of p-ERK and GLI-1 in ARCaPE cells increased in a time-dependent manner after treatment with hrEGF (p<0.05); however, the expression levels of total ERK in the cells remained relatively unchanged. It also demonstrated that the GLI-1 inhibitor GANT61 could reverse the enhanced invasive effect induced by EGF in ARCaPE cells (p<0.05). Our preliminary in vitro study showed that EGF signaling may increase the invasive capability of ARCaPE human prostate cancer cells via upregulation of p-ERK and the HH signaling transcriptional factor GLI-1. Additionally, this enhanced cell invasive effect was reversed by a GLI-1-specific inhibitor in vitro. Consequently, it indicates that both EGF and HH signaling are synergistically involved in the progression of human prostate cancer ARCaP cells, and GlI-1 may be one of the important effectors, which is activated by EGF downstream signaling, to promote the invasiveness of ARCaPE prostate cancer cells.
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1 

Heidenreich A, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Mottet N, Schmid HP, van der Kwast T, Wiegel T and Zattoni F; European Association of Urology. EAU guidelines on prostate cancer. Part 1: Screening, diagnosis, and treatment of clinically localised disease. Eur Urol. 59:61–71. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Bosetti C, Bertuccio P, Chatenoud L, Negri E, La Vecchia C and Levi F: Trends in mortality from urologic cancers in Europe, 1970–2008. Eur Urol. l60:1–15. 2011.

3 

Mottet N, Bellmunt J, Bolla M, Joniau S, Mason M, Matveev V, Schmid HP, Van der Kwast T, Wiegel T, Zattoni F and Heidenreich A: EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. Eur Urol. 59:572–583. 2011. View Article : Google Scholar

4 

Hammerer P and Madersbacher S: Landmarks in hormonal therapy for prostate cancer. BJU Int. 110(Suppl 1): 23–29. 2012. View Article : Google Scholar

5 

Wolff JM and Mason M: Drivers for change in the management of prostate cancer - guidelines and new treatment techniques. BJU Int. 109(Suppl 6): 33–41. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Gao D, Vahdat LT, Wong S, Chang JC and Mittal V: Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res. 72:4883–4889. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Lim J and Thiery JP: Epithelial-mesenchymal transitions: insights from development. Development. 139:3471–3486. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Nieto MA and Cano A: The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Semin Cancer Biol. 22:361–368. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Acloque H, Adams MS, Fishwick K, Bronner-Fraser M and Nieto MA: Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest. 119:1438–1449. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Zhau HE, Odero-Marah V, Lue HW, Nomura T, Wang R, Chu G, Liu ZR, Zhou BP, Huang WC and Chung LW: Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model. Clin Exp Metastasis. 25:601–610. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Zhau HY, Chang SM, Chen BQ, Wang Y, Zhang H, Kao C, Sang QA, Pathak SJ and Chung LW: Androgen-repressed phenotype in human prostate cancer. Proc Natl Acad Sci USA. 93:15152–15157. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Zhau HE, Li CL and Chung LW: Establishment of human prostate carcinoma skeletal metastasis models. Cancer. 88(12 Suppl): 2995–3001. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK and Batra SK: Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets. 16:15–31. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Gregg J and Fraizer G: Transcriptional regulation of EGR1 by EGF and the ERK signaling pathway in prostate cancer cells. Genes Cancer. 2:900–909. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Teixeira AL, Ribeiro R, Cardoso D, Pinto D, Lobo F, Fraga A, Pina F, Calais-da-Silva F and Medeiros R: Genetic polymorphism in EGF is associated with prostate cancer aggressiveness and progression-free interval in androgen blockade-treated patients. Clin Cancer Res. 14:3367–3371. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Cathomas R, Rothermundt C, Klingbiel D, Bubendorf L, Jaggi R, Betticher DC, Brauchli P, Cotting D, Droege C, Winterhalder R, Siciliano D, Berthold DR, Pless M, Schiess R, von Moos R and Gillessen S; Swiss Group for Clinical Cancer Research SAKK. Efficacy of cetuximab in metastatic castration-resistant prostate cancer might depend on EGFR and PTEN expression: results from a phase II trial (SAKK 08/07). Clin Cancer Res. 18:6049–6057. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Humez S, Monet M, Legrand G, Lepage G, Delcourt P and Prevarskaya N: Epidermal growth factor-induced neuroendocrine differentiation and apoptotic resistance of androgen-independent human prostate cancer cells. Endocr Relat Cancer. 13:181–195. 2006. View Article : Google Scholar

18 

Traish AM and Morgentaler A: Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth. Br J Cancer. 101:1949–1956. 2009. View Article : Google Scholar

19 

Gan Y, Shi C, Inge L, Hibner M, Balducci J and Huang Y: Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells. Oncogene. 29:4947–4958. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Chen M, Carkner R and Buttyan R: The Hedgehog/Gli signaling paradigm in prostate cancer. Expert Rev Endocrinol Metab. 6:453–467. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Kim TJ, Lee JY, Hwang TK, Kang CS and Choi YJ: Hedgehog signaling protein expression and its association with prognostic parameters in prostate cancer: a retrospective study from the view point of new 2010 anatomic stage/prognostic groups. J Surg Oncol. 104:472–479. 2011. View Article : Google Scholar

22 

Efstathiou E, Karlou M, Wen S, Hoang A, Pettaway CA, Pisters LL, Maity S, Troncoso P and Logothetis CJ: Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers. Prostate. 73:153–161. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Sheng T, Li C, Zhang X, Chi S, He N, Chen K, McCormick F, Gatalica Z and Xie J: Activation of the Hedgehog pathway in advanced prostate cancer. Mol Cancer. 3:292004. View Article : Google Scholar : PubMed/NCBI

24 

Wu K, Fan J, Zhang L, Ning Z, Zeng J, Zhou J, Li L, Chen Y, Zhang T, Wang X, Hsieh JT and He D: PI3K/Akt to GSK3β/β-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription. Cell Signal. 24:2273–2282. 2012.

25 

Xue Y, Li L, Zhang D, Wu K, Chen Y, Zeng J, Wang X and He D: Twisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction. PLoS One. 6:e277482011. View Article : Google Scholar : PubMed/NCBI

26 

Zhu G, Zhau HE, He H, Zhang L, Shehata B, Wang X, Cerwinka WH, Elmore J and He D: Sonic and desert Hedgehog signaling in human fetal prostate development. Prostate. 67:674–684. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Li L, He D, He H, Wang X, Zhang L, Luo Y and Nan X: Overexpression of PML induced apoptosis in bladder cancer cell by caspase dependent pathway. Cancer Lett. 236:259–268. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Podlasek CA, Barnett DH, Clemens JQ, Bak PM and Bushman W: Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol. 209:28–39. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C, Beachy PA and Shen MM: Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol. 267:387–398. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Freestone SH, Marker P, Grace OC, Tomlinson DC, Cunha GR, Harnden P and Thomson AA: Sonic Hedgehog regulates prostatic growth and epithelial differentiation. Dev Biol. 264:352–362. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Pu Y, Huang L and Prins GS: Sonic Hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Dev Biol. 273:257–275. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Sanchez P, Hernández AM, Stecca B, Kahler AJ, DeGueme AM, Barrett A, Beyna M, Datta MW, Datta S and Ruiz i Altaba A: Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA. 101:12561–12566. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Stecca B, Mas C and Ruiz i Altaba A: Interference with HH-GLI signaling inhibits prostate cancer. Trends Mol Med. 11:199–203. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Azoulay S, Terry S, Chimingqi M, Sirab N, Faucon H, Gil Diez de Medina S, Moutereau S, Maillé P, Soyeux P, Abbou C, Salomon L, Vacherot F, de La Taille A, Loric S and Allory Y: Comparative expression of Hedgehog ligands at different stages of prostate carcinoma progression. J Pathol. 216:460–470. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM and Beachy PA: Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 431:707–712. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Shaw G, Price AM, Ktori E, Bisson I, Purkis PE, McFaul S, Oliver RT and Prowse DM: Hedgehog signalling in androgen independent prostate cancer. Eur Urol. 54:1333–1343. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Chen G, Goto Y, Sakamoto R, Tanaka K, Matsubara E, Nakamura M, Zheng H, Lu J, Takayanagi R and Nomura M: GLI1, a crucial mediator of sonic Hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor. Biochem Biophys Res Commun. 404:809–815. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Ingham PW, Nakano Y and Seger C: Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet. 12:393–406. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Yang L, Xie G, Fan Q and Xie J: Activation of the Hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene. 29:469–481. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Varjosalo M and Taipale J: Hedgehog: functions and mechanisms. Genes Dev. 22:2454–2472. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Lauth M and Toftgård R: Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle. 6:2458–2463. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Jenkins D: Hedgehog signalling: emerging evidence for non-canonical pathways. Cell Signal. 21:1023–1034. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Stecca B and Ruiz i Altaba A: Context-dependent regulation of the GLI code in cancer by Hedgehog and non-Hedgehog signals. J Mol Cell Biol. 2:84–95. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Ruiz i Altaba A, Mas C and Stecca B: The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 17:438–447. 2007.PubMed/NCBI

45 

Riobo NA, Lu K and Emerson CP Jr: Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle. 5:1612–1615. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Migliaccio A, Castoria G, Di Domenico M, Ciociola A, Lombardi M, De Falco A, Nanayakkara M, Bottero D, De Stasio R, Varricchio L and Auricchio F: Crosstalk between EGFR and extranuclear steroid receptors. Ann NY Acad Sci. 1089:194–200. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Brand TM, Iida M, Li C and Wheeler DL: The nuclear epidermal growth factor receptor signaling network and its role in cancer. Discov Med. 12:419–432. 2011.PubMed/NCBI

48 

Dhomen NS, Mariadason J, Tebbutt N and Scott AM: Therapeutic targeting of the epidermal growth factor receptor in human cancer. Crit Rev Oncog. 17:31–50. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Peraldo-Neia C, Migliardi G, Mello-Grand M, Montemurro F, Segir R, Pignochino Y, Cavalloni G, Torchio B, Mosso L, Chiorino G and Aglietta M: Epidermal growth factor receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer. BMC Cancer. 11:312011. View Article : Google Scholar : PubMed/NCBI

50 

Schlomm T, Kirstein P, Iwers L, Daniel B, Steuber T, Walz J, Chun FH, Haese A, Kollermann J, Graefen M, Huland H, Sauter G, Simon R and Erbersdobler A: Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer. Clin Cancer Res. 13:6579–6584. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Shariat SF, Bensalah K, Karam JA, Roehrborn CG, Gallina A, Lotan Y, Slawin KM and Karakiewicz PI: Preoperative plasma HER2 and epidermal growth factor receptor for staging and prognostication in patients with clinically localized prostate cancer. Clin Cancer Res. 13:5377–5384. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Festuccia C, Gravina GL, Angelucci A, Millimaggi D, Muzi P, Vicentini C and Bologna M: Additive antitumor effects of the epidermal growth factor receptor tyrosine kinase inhibitor, gefitinib (Iressa), and the nonsteroidal antiandrogen, bicalutamide (Casodex), in prostate cancer cells in vitro. Int J Cancer. 115:630–640. 2005. View Article : Google Scholar

53 

Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A and Ruiz i Altaba A: Sonic Hedgehog controls stem cell behavior in the postnatal and adult brain. Development. 132:335–344. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Palma V and Ruiz i Altaba A: Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development. 131:337–345. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Bigelow RL, Jen EY, Delehedde M, Chari NS and McDonnell TJ: Sonic Hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes. J Invest Dermatol. 124:457–465. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP and Aberger F: Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Mol Cell Biol. 26:6283–6298. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M and Aberger F: Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res. 69:1284–1292. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu G, Zhou J, Song W, Wu D, Dang Q, Zhang L, Li L, Wang X and He D: Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncol Rep 30: 904-910, 2013.
APA
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L. ... He, D. (2013). Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncology Reports, 30, 904-910. https://doi.org/10.3892/or.2013.2534
MLA
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L., Li, L., Wang, X., He, D."Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells". Oncology Reports 30.2 (2013): 904-910.
Chicago
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L., Li, L., Wang, X., He, D."Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells". Oncology Reports 30, no. 2 (2013): 904-910. https://doi.org/10.3892/or.2013.2534
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x
Spandidos Publications style
Zhu G, Zhou J, Song W, Wu D, Dang Q, Zhang L, Li L, Wang X and He D: Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncol Rep 30: 904-910, 2013.
APA
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L. ... He, D. (2013). Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells. Oncology Reports, 30, 904-910. https://doi.org/10.3892/or.2013.2534
MLA
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L., Li, L., Wang, X., He, D."Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells". Oncology Reports 30.2 (2013): 904-910.
Chicago
Zhu, G., Zhou, J., Song, W., Wu, D., Dang, Q., Zhang, L., Li, L., Wang, X., He, D."Role of GLI-1 in epidermal growth factor-induced invasiveness of ARCaPE prostate cancer cells". Oncology Reports 30, no. 2 (2013): 904-910. https://doi.org/10.3892/or.2013.2534
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