GATA6 predicts prognosis and hepatic metastasis of colorectal cancer

  • Authors:
    • Fei Shen
    • Jianglin Li
    • Wensong Cai
    • Guanghui Zhu
    • Weili Gu
    • Lin Jia
    • Bo Xu
  • View Affiliations

  • Published online on: June 19, 2013     https://doi.org/10.3892/or.2013.2544
  • Pages: 1355-1361
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Abstract

Liver metastasis is a major cause of mortality for colorectal cancer (CRC). However, the underlying mechanisms remain largely unknown. GATA binding protein 6 (GATA6), a zinc-finger transcription factor, is expressed in the colorectal epithelium. We investigated the clinical significance of GATA6 and its role in invasion and metastasis in CRC. Expression of GATA6 in 89 cancerous, 35 adjacent normal and 39 liver metastatic samples from 89 CRC patients undergoing surgical resection was detected by immunohistochemical (IHC) methods. The effect of GATA6 on invasion and metastasis was assessed in CRC cells by shRNA lentivirus or expressed-plasmid transfection. We found that GATA6 expression was significantly higher in liver metastatic tissues compared with adjacent normal tissues. Aberrant GATA6 expression in CRC was associated with liver metastasis. Kaplan-Meier analysis showed GATA6 expression correlated with poor overall survival (OS) in CRC. The cell invasion and migration of established CRC cell lines were decreased by GATA6 knockdown and enhanced by GATA6 overexpression in vitro. Thus, aberrant expression of GATA6 correlates with poor prognosis and liver metastasis in CRC.
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September 2013
Volume 30 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shen F, Li J, Cai W, Zhu G, Gu W, Jia L and Xu B: GATA6 predicts prognosis and hepatic metastasis of colorectal cancer. Oncol Rep 30: 1355-1361, 2013.
APA
Shen, F., Li, J., Cai, W., Zhu, G., Gu, W., Jia, L., & Xu, B. (2013). GATA6 predicts prognosis and hepatic metastasis of colorectal cancer. Oncology Reports, 30, 1355-1361. https://doi.org/10.3892/or.2013.2544
MLA
Shen, F., Li, J., Cai, W., Zhu, G., Gu, W., Jia, L., Xu, B."GATA6 predicts prognosis and hepatic metastasis of colorectal cancer". Oncology Reports 30.3 (2013): 1355-1361.
Chicago
Shen, F., Li, J., Cai, W., Zhu, G., Gu, W., Jia, L., Xu, B."GATA6 predicts prognosis and hepatic metastasis of colorectal cancer". Oncology Reports 30, no. 3 (2013): 1355-1361. https://doi.org/10.3892/or.2013.2544