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Article

Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates

  • Authors:
    • Arvind Thakkar
    • Irene V. Bijnsdorp
    • Albert A. Geldof
    • Girish V. Shah
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, University of Louisiana, College of Pharmacy, Monroe, LA 71291, USA, Department of Urology, VU University Medical Center, Amsterdam, the Netherlands
  • Pages: 1265-1274
    |
    Published online on: July 2, 2013
       https://doi.org/10.3892/or.2013.2583
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Abstract

Expression of the neuroendocrine peptide calcitonin (CT) and its receptor (CTR) is frequently elevated in prostate cancers (PCs), and activation of the CT-CTR axis in non-invasive PC cells induces an invasive phenotype. We aimed to link CT/CTR expression in prostate specimens to clinicopathological parameters of PC. We analyzed CT and CTR expression in cohorts of benign prostates and primary PCs with/without metastatic disease by immunohistochemistry. Furthermore, we correlated CT/CTR expression with several clinicopathological parameters. CT/CTR immunostaining in benign prostate acini was predominantly localized to basal epithelium. However, this spatial specificity was lost in malignant prostates. PC sections displayed a remarkable increase in cell populations expressing CT/CTR and their staining intensity. Tumors with higher CT/CTR expression consistently displayed metastatic disease and poor clinical outcome. High CT/CTR expression in primary prostate tumors may serve as a prognostic indicator of disease aggressiveness and poor clinical outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Thakkar A, Bijnsdorp IV, Geldof AA and Shah GV: Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates. Oncol Rep 30: 1265-1274, 2013.
APA
Thakkar, A., Bijnsdorp, I.V., Geldof, A.A., & Shah, G.V. (2013). Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates. Oncology Reports, 30, 1265-1274. https://doi.org/10.3892/or.2013.2583
MLA
Thakkar, A., Bijnsdorp, I. V., Geldof, A. A., Shah, G. V."Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates". Oncology Reports 30.3 (2013): 1265-1274.
Chicago
Thakkar, A., Bijnsdorp, I. V., Geldof, A. A., Shah, G. V."Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates". Oncology Reports 30, no. 3 (2013): 1265-1274. https://doi.org/10.3892/or.2013.2583
Copy and paste a formatted citation
x
Spandidos Publications style
Thakkar A, Bijnsdorp IV, Geldof AA and Shah GV: Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates. Oncol Rep 30: 1265-1274, 2013.
APA
Thakkar, A., Bijnsdorp, I.V., Geldof, A.A., & Shah, G.V. (2013). Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates. Oncology Reports, 30, 1265-1274. https://doi.org/10.3892/or.2013.2583
MLA
Thakkar, A., Bijnsdorp, I. V., Geldof, A. A., Shah, G. V."Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates". Oncology Reports 30.3 (2013): 1265-1274.
Chicago
Thakkar, A., Bijnsdorp, I. V., Geldof, A. A., Shah, G. V."Profiling of the calcitonin-calcitonin receptor axis in primary prostate cancer: clinical implications and molecular correlates". Oncology Reports 30, no. 3 (2013): 1265-1274. https://doi.org/10.3892/or.2013.2583
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