Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
September 2013 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2013 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis

  • Authors:
    • Yusuke Takahashi
    • Genta Sawada
    • Tetsuya Sato
    • Junji Kurashige
    • Kosuke Mima
    • Tae Matsumura
    • Ryutaro Uchi
    • Hiroki Ueo
    • Masahisa Ishibashi
    • Yuki Takano
    • Sayuri Akiyoshi
    • Hidetoshi Eguchi
    • Tomoya Sudo
    • Keishi Sugimachi
    • Jun‑Ichi Tanaka
    • Shin-Ei Kudo
    • Yuichiro Doki
    • Masaki Mori
    • Koshi Mimori
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan, Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan, Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Suita, Japan
  • Pages: 1488-1496
    |
    Published online on: July 8, 2013
       https://doi.org/10.3892/or.2013.2602
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumor size indicates the extent of cell proliferation in most cases of colorectal cancer (CRC), although there are some advanced small tumors with metastases. Lymph node metastasis is a significant factor that greatly impacts disease prognosis in CRC cases. The underlying factors that cause lymph node metastasis in CRC cells are not fully understood. We investigated the mechanism that might induce CRC metastasis by focusing on smaller sized (<2 cm) invasive tumors. We carried out gene expression array analysis for CRC cases; group 1 consisted of 6 cases with tumors <2 cm with metastases, and group 2 consisted of 65 cases with tumors >2 cm without metastases. Results were validated using gene expression array data from an additional 77 cases and another bulk case set of 172 cases. Gene ontology and pathway analysis using microarray data revealed that anti-apoptotic activity had a crucial role in CRC metastasis. High mobility group A1 (HMGA1) was identified as a biomarker for poor prognosis and metastasis formation. HMGA1 expression levels were higher in lymph node-positive cases than in lymph node-negative cases, even in subgroup analysis of submucosal invasive cases. The present study strongly supports the clinical significance of HMGA1 expression as a predictive indicator of lymph node metastasis in CRC cases, even in submucosal invasive cases which could be cured by local resection.
View Figures

Figure 1

View References

1 

Grade M, Hormann P, Becker S, et al: Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas. Cancer Res. 67:41–56. 2007. View Article : Google Scholar

2 

Hao JM, Chen JZ, Sui HM, et al: A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer. J Pathol. 220:475–489. 2010.PubMed/NCBI

3 

Meding S, Balluff B, Elsner M, et al: Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer. J Pathol. 228:459–470. 2012.PubMed/NCBI

4 

Gunderson LL, Jessup JM, Sargent DJ, Greene FL and Stewart AK: Revised TN categorization for colon cancer based on national survival outcomes data. J Clin Oncol. 28:264–271. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Weitz J, Koch M, Debus J, Hohler T, Galle PR and Buchler MW: Colorectal cancer. Lancet. 365:153–165. 2005. View Article : Google Scholar

6 

Nishida K, Mine S, Utsunomiya T, et al: Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and a cDNA microarray. Cancer Res. 65:401–409. 2005.PubMed/NCBI

7 

Quackenbush J: Microarray data normalization and transformation. Nat Genet. 32(Suppl): 496–501. 2002. View Article : Google Scholar

8 

Brazma A, Hingamp P, Quackenbush J, et al: Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 29:365–371. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Niida A, Smith AD, Imoto S, Aburatani H, Zhang MQ and Akiyama T: Gene set-based module discovery in the breast cancer transcriptome. BMC Bioinformatics. 10:712009. View Article : Google Scholar : PubMed/NCBI

10 

Esposito F, Tornincasa M, Federico A, Chiappetta G, Pierantoni GM and Fusco A: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria. Cell Death Dis. 3:e3832012. View Article : Google Scholar : PubMed/NCBI

11 

Kwon HC, Kim SH, Roh MS, et al: Gene expression profiling in lymph node-positive and lymph node-negative colorectal cancer. Dis Colon Rectum. 47:141–152. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Koehler A, Bataille F, Schmid C, et al: Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage. J Pathol. 204:65–74. 2004. View Article : Google Scholar

13 

Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature. 411:342–348. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Acloque H, Adams MS, Fishwick K, Bronner-Fraser M and Nieto MA: Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest. 119:1438–1449. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Ailles LE and Weissman IL: Cancer stem cells in solid tumors. Curr Opin Biotechnol. 18:460–466. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Grosschedl R, Giese K and Pagel J: HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet. 10:94–100. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Reeves R and Nissen MS: The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem. 265:8573–8582. 1990.PubMed/NCBI

20 

Reeves R: Structure and function of the HMGI(Y) family of architectural transcription factors. Environ Health Perspect. 108(Suppl 5): 803–809. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Zhou X, Benson KF, Ashar HR and Chada K: Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature. 376:771–774. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Chiappetta G, Avantaggiato V, Visconti R, et al: High level expression of the HMGI (Y) gene during embryonic development. Oncogene. 13:2439–2446. 1996.PubMed/NCBI

23 

Chiappetta G, Bandiera A, Berlingieri MT, et al: The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene. 10:1307–1314. 1995.PubMed/NCBI

24 

Chiappetta G, Tallini G, De Biasio MC, et al: Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res. 58:4193–4198. 1998.

25 

Fedele M, Bandiera A, Chiappetta G, et al: Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins. Cancer Res. 56:1896–1901. 1996.PubMed/NCBI

26 

Abe N, Watanabe T, Sugiyama M, et al: Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker. Cancer Res. 59:1169–1174. 1999.PubMed/NCBI

27 

Chiappetta G, Manfioletti G, Pentimalli F, et al: High mobility group HMGI(Y) protein expression in human colorectal hyperplastic and neoplastic diseases. Int J Cancer. 91:147–151. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Tamimi Y, van der Poel HG, Denyn MM, et al: Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization. Cancer Res. 53:5512–5516. 1993.PubMed/NCBI

29 

Abe N, Watanabe T, Izumisato Y, et al: Diagnostic significance of high mobility group I(Y) protein expression in intraductal papillary mucinous tumors of the pancreas. Pancreas. 25:198–204. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Bandiera A, Bonifacio D, Manfioletti G, et al: Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix. Cancer Res. 58:426–431. 1998.PubMed/NCBI

31 

Masciullo V, Baldassarre G, Pentimalli F, et al: HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas. Carcinogenesis. 24:1191–1198. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Chiappetta G, Botti G, Monaco M, et al: HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res. 10:7637–7644. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Pomeroy SL, Tamayo P, Gaasenbeek M, et al: Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 415:436–442. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Ben-Porath I, Thomson MW, Carey VJ, et al: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet. 40:499–507. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Mu G, Liu H, Zhou F, et al: Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. Hum Pathol. 41:493–502. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Balcerczak M, Pasz-Walczak G, Balcerczak E, Wojtylak M, Kordek R and Mirowski M: HMGI(Y) gene expression in colorectal cancer: comparison with some histological typing, grading, and clinical staging. Pathol Res Pract. 199:641–646. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Pierantoni GM, Rinaldo C, Mottolese M, et al: High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J Clin Invest. 117:693–702. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Esposito F, Tornincasa M, Chieffi P, De Martino I, Pierantoni GM and Fusco A: High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. Cancer Res. 70:5379–5388. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Belton A, Gabrovsky A, Bae YK, et al: HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells. PloS One. 7:e300342012. View Article : Google Scholar : PubMed/NCBI

40 

Morson BC, Whiteway JE, Jones EA, Macrae FA and Williams CB: Histopathology and prognosis of malignant colorectal polyps treated by endoscopic polypectomy. Gut. 25:437–444. 1984. View Article : Google Scholar : PubMed/NCBI

41 

Kyzer S, Begin LR, Gordon PH and Mitmaker B: The care of patients with colorectal polyps that contain invasive adenocarcinoma. Endoscopic polypectomy or colectomy? Cancer. 70:2044–2050. 1992. View Article : Google Scholar : PubMed/NCBI

42 

Minamoto T, Mai M, Ogino T, et al: Early invasive colorectal carcinomas metastatic to the lymph node with attention to their nonpolypoid development. Am J Gastroenterol. 88:1035–1039. 1993.PubMed/NCBI

43 

Nusko G, Mansmann U, Partzsch U, et al: Invasive carcinoma in colorectal adenomas: multivariate analysis of patient and adenoma characteristics. Endoscopy. 29:626–631. 1997. View Article : Google Scholar : PubMed/NCBI

44 

Cooper HS: Surgical pathology of endoscopically removed malignant polyps of the colon and rectum. Am J Surg Pathol. 7:613–623. 1983. View Article : Google Scholar : PubMed/NCBI

45 

Colacchio TA, Forde KA and Scantlebury VP: Endoscopic polypectomy: inadequate treatment for invasive colorectal carcinoma. Ann Surg. 194:704–707. 1981. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Takahashi Y, Sawada G, Sato T, Kurashige J, Mima K, Matsumura T, Uchi R, Ueo H, Ishibashi M, Takano Y, Takano Y, et al: Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis. Oncol Rep 30: 1488-1496, 2013.
APA
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T. ... Mimori, K. (2013). Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis. Oncology Reports, 30, 1488-1496. https://doi.org/10.3892/or.2013.2602
MLA
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T., Uchi, R., Ueo, H., Ishibashi, M., Takano, Y., Akiyoshi, S., Eguchi, H., Sudo, T., Sugimachi, K., Tanaka, J., Kudo, S., Doki, Y., Mori, M., Mimori, K."Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis". Oncology Reports 30.3 (2013): 1488-1496.
Chicago
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T., Uchi, R., Ueo, H., Ishibashi, M., Takano, Y., Akiyoshi, S., Eguchi, H., Sudo, T., Sugimachi, K., Tanaka, J., Kudo, S., Doki, Y., Mori, M., Mimori, K."Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis". Oncology Reports 30, no. 3 (2013): 1488-1496. https://doi.org/10.3892/or.2013.2602
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi Y, Sawada G, Sato T, Kurashige J, Mima K, Matsumura T, Uchi R, Ueo H, Ishibashi M, Takano Y, Takano Y, et al: Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis. Oncol Rep 30: 1488-1496, 2013.
APA
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T. ... Mimori, K. (2013). Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis. Oncology Reports, 30, 1488-1496. https://doi.org/10.3892/or.2013.2602
MLA
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T., Uchi, R., Ueo, H., Ishibashi, M., Takano, Y., Akiyoshi, S., Eguchi, H., Sudo, T., Sugimachi, K., Tanaka, J., Kudo, S., Doki, Y., Mori, M., Mimori, K."Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis". Oncology Reports 30.3 (2013): 1488-1496.
Chicago
Takahashi, Y., Sawada, G., Sato, T., Kurashige, J., Mima, K., Matsumura, T., Uchi, R., Ueo, H., Ishibashi, M., Takano, Y., Akiyoshi, S., Eguchi, H., Sudo, T., Sugimachi, K., Tanaka, J., Kudo, S., Doki, Y., Mori, M., Mimori, K."Microarray analysis reveals that high mobility group A1 is involved in colorectal cancer metastasis". Oncology Reports 30, no. 3 (2013): 1488-1496. https://doi.org/10.3892/or.2013.2602
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team