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Article

CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo

  • Authors:
    • Jang-Chang Lee
    • Li-Chen Chou
    • Jin-Chemg Lien
    • Jia-Chiun Wu
    • Chi-Hung Huang
    • Chao-Ho Chung
    • Fang-Yu Lee
    • Li-Jiau Huang
    • Sheng-Chu Kuo
    • Tzong-Der Way
  • View Affiliations / Copyright

    Affiliations: Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C., Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan, R.O.C., Taiwan Advance Biopharm, Inc., Taipei, Taiwan, R.O.C., Yung-Shin Pharmaceutical Industry Co., Ltd., Tachia, Taichung, Taiwan, R.O.C.
  • Pages: 1762-1772
    |
    Published online on: July 23, 2013
       https://doi.org/10.3892/or.2013.2634
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Abstract

HER2 has become a solicitous therapeutic target in metastatic and clinical drug-resistant cancer. Here, we evaluated whether or not 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) and its furopyrazole and thienopyrazole analogues repress the expression of the HER2 protein. Among the test compounds, (1-benzyl-3-(p-hydroxymethylphenyl)-5-methylfuro[3,2-c]pyrazol) (CLC604), an isosteric analogue of YC-1, significantly suppressed the expression of HER2, and preferentially inhibited cell proliferation and induced apoptosis in HER2-overexpressing cancer cells. Our results revealed that CLC604 reduced HER2 expression through a post-transcriptional mechanism and involvement of proteasomal activity. CLC604 disrupted the association of 90-kDa heat shock protein (Hsp90) with HER2 resulting from the inhibition of Hsp90 ATPase activity. Moreover, we found that CLC604 significantly enhanced the antitumor efficacy of clinical drugs against HER2-overexpressing tumors and efficiently reduced HER2-induced drug resistance in vitro and in vivo. These findings suggest that CLC604 should be developed further as a novel antitumor drug candidate for the treatment of drug-resistant cancer.
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1 

Stearns V, Schneider B, Henry NL, Hayes DF and Flockhart DA: Breast cancer treatment and ovarian failure: risk factors and emerging genetic determinants. Nat Rev Cancer. 6:886–893. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Chiang CT, Way TD and Lin JK: Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with rapamycin. Mol Cancer Ther. 6:2127–2138. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 235:177–182. 1987. View Article : Google Scholar : PubMed/NCBI

4 

Yu D and Hung MC: Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene. 19:6115–6121. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Meric-Bernstam F and Hung MC: Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res. 12:6326–6330. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Esteva FJ, Yu D, Hung MC and Hortobagyi GN: Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol. 7:98–107. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Vogel CL, Cobleigh MA, Tripathy D, et al: Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 20:719–726. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Cardoso F, Piccart MJ, Durbecq V and Di Leo A: Resistance to trastuzumab: a necessary evil or a temporary challenge? Clin Breast Cancer. 3:247–257. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Lan KH, Lu CH and Yu D: Mechanisms of trastuzumab resistance and their clinical implications. Ann NY Acad Sci. 1059:70–75. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Trepel J, Mollapour M, Giaccone G and Neckers L: Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 10:537–549. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y and Neckers L: Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem. 276:3702–3708. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Richter K, Reinstein J and Buchner J: A Grp on the Hsp90 mechanism. Mol Cell. 28:177–179. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Solit DB, Zheng FF, Drobnjak M, et al: 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res. 8:986–993. 2002.PubMed/NCBI

14 

Ko FN, Wu CC, Kuo SC, Lee FY and Teng CM: YC-1, a novel activator of platelet guanylate cyclase. Blood. 84:4226–4233. 1994.PubMed/NCBI

15 

Chou LC, Huang LJ, Yang JS, Lee FY, Teng CM and Kuo SC: Synthesis of furopyrazol analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents. Bioorg Med Chem. 15:1732–1740. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Pan SL, Guh JH, Peng CY, et al: YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. J Pharmacol Exp Ther. 314:35–42. 2005.

17 

Huang YT, Pan SL, Guh JH, Chang YL, Lee FY, Kuo SC and Teng CM: YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells. Mol Cancer Ther. 4:1628–1635. 2005.PubMed/NCBI

18 

Chun YS, Yeo EJ, Choi E, Teng CM, Bae JM, Kim MS and Park JW: Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol. 61:947–954. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Mujoo K, Sharin VG, Bryan NS, et al: Role of nitric oxide signaling components in differentiation of embryonic stem cells into myocardial cells. Proc Natl Acad Sci USA. 105:18924–18929. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Yun S, Lee SH, Kang YH, et al: YC-1 enhances natural killer cell differentiation from hematopoietic stem cells. Int Immunopharmacol. 10:481–486. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Chou LC, Huang LJ, Hsu MH, et al: Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents. Eur J Med Chem. 45:1395–1402. 2010.PubMed/NCBI

22 

Way TD, Lee JC, Kuo DH, et al: Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional Chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 cells. J Agric Food Chem. 58:3356–3365. 2010.PubMed/NCBI

23 

Lin VC, Chou CH, Lin YC, et al: Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway. J Agric Food Chem. 58:4786–4793. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Panaretou B, Prodromou C, Roe SM, O’Brien R, Ladbury JE, Piper PW and Pearl LH: ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J. 17:4829–4836. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Oude Munnink TH, Korte MA, Nagengast WB, et al: 89 Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft. Eur J Cancer. 46:678–684. 2010.PubMed/NCBI

26 

Evgenov OV, Pacher P, Schmidt PM, Haskó G, Schmidt HH and Stasch JP: NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 5:755–768. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Liu XM, Peyton KJ, Mendelev NN, Wang H, Tulis DA and Durante W: YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells. Mol Pharmacol. 75:208–217. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Wang SW, Pan SL, Guh JH, et al: YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J Pharmacol Exp Ther. 312:917–925. 2005.

29 

Yeo EJ, Chun YS, Cho YS, Kim J, Lee JC, Kim MS and Park JW: YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst. 95:516–525. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Yeh WL, Lu DY, Lin CJ, Liou HC and Fu WM: Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1α accumulation and VEGF expression. Mol Pharmacol. 72:440–449. 2007.PubMed/NCBI

31 

Zhao Q, Du J, Gu H, Teng X, Zhang Q, Qin H and Liu N: Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells. Pancreas. 34:242–247. 2007. View Article : Google Scholar

32 

Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC and Burrows FJ: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 425:407–410. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Sawai A, Chandarlapaty S, Greulich H, et al: Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Res. 68:589–596. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Morrow PK, Zambrana F and Esteva FJ: Recent advances in systemic therapy: advances in systemic therapy for HER2-positive metastatic breast cancer. Breast Cancer Res. 11:2072009. View Article : Google Scholar : PubMed/NCBI

35 

Allred DC, Clark GM, Tandon AK, et al: HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma. J Clin Oncol. 10:599–605. 1992.PubMed/NCBI

36 

Harris JR, Lippman ME, Veronesi U and Willett W: Breast cancer (1). N Engl J Med. 327:319–328. 1992. View Article : Google Scholar

37 

Harris JR, Lippman ME, Veronesi U and Willett W: Breast cancer (2). N Engl J Med. 327:390–398. 1992. View Article : Google Scholar : PubMed/NCBI

38 

Harris JR, Lippman ME, Veronesi U and Willett W: Breast cancer (3). N Engl J Med. 327:473–480. 1992. View Article : Google Scholar

39 

Felip E, Del Campo JM, Rubio D, Vidal MT, Colomer R and Bermejo B: Overexpression of c-erbB-2 in epithelial ovarian cancer. Prognostic value and relationship with response to chemotherapy. Cancer. 75:2147–2152. 1995. View Article : Google Scholar : PubMed/NCBI

40 

Ramalingam SS, Egorin MJ, Ramanathan RK, et al: A phase I study of 17-allylamino-17-demethoxygeldanamycin combined with Taxol in patients with advanced solid malignancies. Clin Cancer Res. 14:3456–3461. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee J, Chou L, Lien J, Wu J, Huang C, Chung C, Lee F, Huang L, Kuo S, Way T, Way T, et al: CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo. Oncol Rep 30: 1762-1772, 2013.
APA
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C. ... Way, T. (2013). CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo. Oncology Reports, 30, 1762-1772. https://doi.org/10.3892/or.2013.2634
MLA
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C., Lee, F., Huang, L., Kuo, S., Way, T."CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo". Oncology Reports 30.4 (2013): 1762-1772.
Chicago
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C., Lee, F., Huang, L., Kuo, S., Way, T."CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo". Oncology Reports 30, no. 4 (2013): 1762-1772. https://doi.org/10.3892/or.2013.2634
Copy and paste a formatted citation
x
Spandidos Publications style
Lee J, Chou L, Lien J, Wu J, Huang C, Chung C, Lee F, Huang L, Kuo S, Way T, Way T, et al: CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo. Oncol Rep 30: 1762-1772, 2013.
APA
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C. ... Way, T. (2013). CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo. Oncology Reports, 30, 1762-1772. https://doi.org/10.3892/or.2013.2634
MLA
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C., Lee, F., Huang, L., Kuo, S., Way, T."CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo". Oncology Reports 30.4 (2013): 1762-1772.
Chicago
Lee, J., Chou, L., Lien, J., Wu, J., Huang, C., Chung, C., Lee, F., Huang, L., Kuo, S., Way, T."CLC604 preferentially inhibits the growth of HER2-overexpressing cancer cells and sensitizes these cells to the inhibitory effect of Taxol in vitro and in vivo". Oncology Reports 30, no. 4 (2013): 1762-1772. https://doi.org/10.3892/or.2013.2634
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